Role of phosphoenolpyruvate carboxykinase 1 (pck1) in mediating nutrient metabolism in zebrafish

Lu, Ke; Wu, Jiaqi; Zhang, Yanpeng; Zhuang, Wuyuan; Liang, Xu‐Fang

doi:10.1007/s10142-023-00993-6

Cited by 4 publications

(2 citation statements)

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“…Decreased lipid synthesis was observed in the liver of juvenile golden pomfret, associating with the down-regulated expression of Fas and Acc α genes [50]. Knockdown of the Pck1 gene in zebra sh resulted in up-regulation of the Gck gene expression, leading to increased liver carbohydrate utilization [51]. These ndings suggest that the high concentration gradients of resveratrol used in this experiment promoted hepatic lipid synthesis and inhibited sugar synthesis in Siberian sturgeon.…”

Section: Discussionmentioning

confidence: 53%

Transcriptome analysis reveals resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon

Yang,

Yan,

Pang

et al. 2024

Preprint

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Resveratrol, known for its antioxidant properties and ability to regulate glycolipid metabolism, has been revealed its benefit effects on the liver health of sturgeon. However, further investigation is needed to understand the specific mechanism of resveratrol's impact. In this study, we explore how resveratrol affects the liver of Siberian sturgeon at a specific concentration. The results showed that resveratrol treatment led to a significant increase in apoptosis after hepatic lipid synthesis, but did not activate the antioxidant NRF2/KEAP1 pathway or enhance antioxidant enzyme activity. Transcriptomics analysis also revealed significant changes in regulatory pathways related to glycolysis, including the PPAR signaling pathway, Insulin signaling pathway, Fatty acid biosynthesis, and Glycolysis/Gluconeogenesis. These findings highlight the close relationship between resveratrol and glycolipid metabolism. Moreover, the study demonstrated that high concentrations of resveratrol can have physiological toxicity to the liver of Siberian sturgeon, providing valuable insights for future research on fish feed additives dosage.

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Section: Discussionmentioning

confidence: 53%

Transcriptome analysis reveals resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon

Yang,

Yan,

Pang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…A gluconeogenic enzyme called phosphoenolpyruvate carboxy kinase (PEPCK) exists as cytoplasmic ( PCK 1 ) and mitochondrial ( PCK 2 ) isoforms [ 6 ]. It is a rate-limiting enzyme that uses the addition of phosphate to pyruvate and the simultaneous cleavage of CO2 from oxaloacetate to catalyze the conversion of oxaloacetate (OAA) and GTP into phosphoenolpyruvate (PEP) and CO2 [ 7 ]. It is now becoming clear that some cancer cells use it as a novel regulator for a specific metabolic pathway for biosynthesis in a nutrient-poor environment [ 8 ].…”

Section: Introductionmentioning

confidence: 99%