Role of Phosphorylated Neurofilament H as a diagnostic and prognostic marker in traumatic brain injury

Ghonemi, Moh Omar; Rabah, A.; Saber, H.; Radwan, Waheed

doi:10.1016/j.ejccm.2013.03.002

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Across studies reporting on the Marshall score for mixed severity cohorts, a positive correlation was found between Marshall score and S100B, 41,58 NSE, 41,58 NFH, 21,51 GFAP, 58 and UCH-L1. 58 However, these findings were inconsistent with many studies demonstrating no associations.…”

Section: Resultsmentioning

confidence: 92%

“…46,47 GFAP measured 7 h from admission was found to be higher in mass lesions, in contrast to UCH-L1, which was significantly higher in diffuse injury. 39 Across studies reporting on the Marshall score for mixed severity cohorts, a positive correlation was found between Marshall score and S100B, 41,58 NSE, 41,58 NFH, 21,51 GFAP, 58 and UCH-L1. 58 However, these findings were inconsistent with many studies demonstrating no associations.…”

Section: Biomarker Concentration and Volume Or Number Of Intracranial...mentioning

confidence: 92%

“…• Positive correlations have been observed between the Marshall score and S100B, 29,41,50,58,64 NSE, 41,58,64 NFH, 21,51 GFAP, 58,64 UCH-L1, 58 von Willebrand factor (vWF), 16 and an inverse correlation with uric acid levels. 23 However, findings were not consistent.…”

Section: Table 2 Summary Of Key Findings Of Biomarker Imaging Relatio...mentioning

confidence: 99%

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Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review

et al. 2021

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BACKGROUND:Blood biomarkers are of increasing importance in the diagnosis and assessment of traumatic brain injury (TBI). However, the relationship between them and lesions seen on imaging remains unclear.OBJECTIVE:To perform a systematic review of the relationship between blood biomarkers and intracranial lesion types, intracranial lesion injury patterns, volume/number of intracranial lesions, and imaging classification systems.METHODS:We searched Medical Literature Analysis and Retrieval System Online, Excerpta Medica dataBASE, and Cumulative Index to Nursing and Allied Health Literature from inception to May 2021, and the references of included studies were also screened. Heterogeneity in study design, biomarker types, imaging modalities, and analyses inhibited quantitative analysis, with a qualitative synthesis presented.RESULTS:Fifty-nine papers were included assessing one or more biomarker to imaging comparisons per paper: 30 assessed imaging classifications or injury patterns, 28 assessed lesion type, and 11 assessed lesion volume or number. Biomarker concentrations were associated with the burden of brain injury, as assessed by increasing intracranial lesion volume, increasing numbers of traumatic intracranial lesions, and positive correlations with imaging classification scores. There were inconsistent findings associating different biomarkers with specific imaging phenotypes including diffuse axonal injury, cerebral edema, and intracranial hemorrhage.CONCLUSION:Blood-based biomarker concentrations after TBI are consistently demonstrated to correlate burden of intracranial disease. The relation with specific injury types is unclear suggesting a lack of diagnostic specificity and/or is the result of the complex and heterogeneous nature of TBI.

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Section: Resultsmentioning

confidence: 92%

Section: Biomarker Concentration and Volume Or Number Of Intracranial...mentioning

confidence: 92%

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Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review

et al. 2021

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“…Serum pNF-H level was also elevated in patients after TBI and was negatively correlated with GCS after admission and 7 days after injuryhigher pNF-H level with lower GCS scores. Furthermore, an increased blood pNF-H concentration correlated with greater brain lesions and mortality after 3 months [56]. Peripheral release pattern of neurofilaments is associated with multiple clinical symptoms after TBI.…”

Section: Neurofilamentsmentioning

confidence: 88%

Looking for novel, brain-derived, peripheral biomarkers of neurological disorders

Chmielewska

Szyndler

Makowska

et al. 2018

Neurologia i Neurochirurgia Polska

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The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.

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“…pNF-H level in plasma gets elevated in patients with traumatic brain injury (TBI), subarachnoid hemorrhage, and amyotrophic lateral sclerosis. [ 9 11 12 ] Prolonged elevation of plasma pNF-H in patients with central nervous system disorders further suggests that it is due to the continuous axonal degeneration, such as Wallerian degeneration or secondary axonal damage. pNF-H is stable on release from neurons and can be captured and detected with exceptionally high avidity due to its exotic multi-epitope nature.…”

Section: Introductionmentioning

confidence: 99%

Phosphorylated neurofilament heavy: A potential blood biomarker to evaluate the severity of acute spinal cord injuries in adults

Singh

Kumar

Ali

et al. 2017

Int J Crit Illn Inj Sci

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Aims:The aim of this study is to analyze the serial estimation of phosphorylated neurofilament heavy (pNF-H) in blood plasma that would act as a potential biomarker for early prediction of the neurological severity of acute spinal cord injuries (SCI) in adults.Settings and Design:Pilot study/observational study.Subjects and Methods:A total of 40 patients (28 cases and 12 controls) of spine injury were included in this study. In the enrolled cases, plasma level of pNF-H was evaluated in blood samples and neurological evaluation was performed by the American Spinal Injury Association Injury Scale at specified period. Serial plasma neurofilament heavy values were then correlated with the neurological status of these patients during follow-up visits and were analyzed statistically.Statistical Analysis Used:Statistical analysis was performed using GraphPad InStat software (version 3.05 for Windows, San Diego, CA, USA). The correlation analysis between the clinical progression and pNF-H expression was done using Spearman's correlation.Results:The mean baseline level of pNF-H in cases was 6.40 ± 2.49 ng/ml, whereas in controls it was 0.54 ± 0.27 ng/ml. On analyzing the association between the two by Mann–Whitney U–test, the difference in levels was found to be statistically significant. The association between the neurological progression and pNF-H expression was determined using correlation analysis (Spearman's correlation). At 95% confidence interval, the correlation coefficient was found to be 0.64, and the correlation was statistically significant.Conclusions:Plasma pNF-H levels were elevated in accordance with the severity of SCI. Therefore, pNF-H may be considered as a potential biomarker to determine early the severity of SCI in adult patients.

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Role of Phosphorylated Neurofilament H as a diagnostic and prognostic marker in traumatic brain injury

Cited by 8 publications

References 15 publications

Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review

Blood Biomarkers and Structural Imaging Correlations Post-Traumatic Brain Injury: A Systematic Review

Looking for novel, brain-derived, peripheral biomarkers of neurological disorders

Phosphorylated neurofilament heavy: A potential blood biomarker to evaluate the severity of acute spinal cord injuries in adults

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