Role of Phosphorylcholine-Specific Immunoglobulin M in Acute Upper Respiratory Tract Infections

Ohori, Junichiro; Jimura, Tomohiro; Kurono, Yuichi

doi:10.1177/0003489419835568

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Cross sectional (IgM) [33] Osteoarthritis Cross sectional (IgM) [32] Chronic kidney disease Mortality, incident CVD and atherosclerosis progress. (IgM and IgG1 [53] Alzheimer s disease Prevalent cases, cross sectional (IgM) [1] Upper respiratory infections Cross sectional (IgM) [34] Chronic lymphatic leukemia Incident cases (IgM) [62]…”

Section: Anca-associated Vasculitismentioning

confidence: 99%

“…Interestingly, other groups have reported associations with protection in other rheumatology-related conditions such as osteoarthritis [ 32 ] and vasculitis [ 33 ] and also in relation to upper respiratory infections (which is interesting given PC’s role as both a DAMP and PAMP [ 34 ].…”

Section: Anti-pc As Protection Marker In Chronic Inflammatory Conditionsmentioning

confidence: 99%

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Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases

Frostegård

2023

Metabolites

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Atherosclerosis and its main consequence, cardiovascular disease (CVD) are nowadays regarded as chronic inflammatory disease conditions, and CVD is the main cause of death in the world. Other examples of chronic inflammation are rheumatic and other autoimmune conditions, but also diabetes, obesity, and even osteoarthritis among others. In addition, infectious diseases can have traits in common with these conditions. Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease, where atherosclerosis is increased and the risk of CVD is very high. This is a clinical problem but could also shed light on the role of the immune system in atherosclerosis and CVD. Underlying mechanisms are of major interest and these are only partially known. Phosphorylcholine (PC) is a small lipid-related antigen, which is both a danger associated molecular pattern (DAMP), and a pathogen associated molecular pattern (PAMP). Antibodies against PC are ubiquitous and 5–10% of circulating IgM is IgM anti-PC. Anti-PC, especially IgM and IgG1 anti-PC, has been associated with protection in the chronic inflammatory conditions mentioned above, and develops during the first years of life, while being present at very low levels at birth. Animal experiments with immunization to raise anti-PC ameliorate atherosclerosis and other chronic inflammatory conditions. Potential mechanisms include anti-inflammatory, immune modulatory, clearance of dead cells and protection against infectious agents. An intriguing possibility is to raise anti-PC levels through immunization, to prevent and/or ameliorate chronic inflammation.

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Section: Anca-associated Vasculitismentioning

confidence: 99%

Section: Anti-pc As Protection Marker In Chronic Inflammatory Conditionsmentioning

confidence: 99%

Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases

Frostegård

2023

Metabolites

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“…Moreover, PC allows bacteria to evade host immune responses and subsequently colonize in the upper respiratory tract [7, 8]. Antibodies against PC (anti-PC) were initially recognized for their anti-infective properties [9] and were later reported to be a protection marker of cardiovascular disease [10], autoimmune diseases [11], as well as fetal growth and premature birth [12]. However, to the best of our knowledge, few studies have assessed the associations between anti-PC and bacterial infections in neonates.…”

Section: Introductionmentioning

confidence: 99%

Associations between cord serum antibodies against phosphorylcholine and bacterial infections in neonates: a prospective cohort study in singletons and twins

Chen,

Zheng,

Tan

et al. 2024

Preprint

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Background. Antibodies against phosphorylcholine (anti-PC) are reported to protect against infection. However, the association between cord serum anti-PC and bacterial infection in neonates is yet to be investigated. This study aimed to investigate these associations among both singletons and twins. Methods. A total of 1007 neonates (329 singletons and 678 twins) within the hospital-based Shenzhen Baoan Birth & Twin cohort were included in this study. Levels of IgM anti-PC, IgG anti-PC, as well as IgM, IgG, and IgA in cord serum were measured by enzyme-linked immunosorbent assay. Diagnoses of bacterial infections were identified within 0-27 days after birth. Multivariable logistic regression with propensity score adjustment was performed to assess the associations between levels of antibodies and neonatal bacterial infections. Results. The mean (standard deviation) levels of IgM and IgG anti-PC were 46.68 (14.15) ng/ml and 73.68 (30.44) ng/ml, respectively. Neonatal bacterial infections were diagnosed in 24 singletons (7.29%) and 48 twins (7.08%). A higher level of IgM anti-PC was associated with a lower risk of neonatal bacterial infections in the analyses of singletons (Odds ratio [OR]: 0.64, 95% confidence interval [CI]: 0.41-0.99) or discordant twin pairs (concerning bacterial infection) (OR: 0.44, 95% CI: 0.20-0.95). Statistically significant association was also shown for IgG among singletons and the first-born twins, but not for IgG anti-PC, IgM, or IgA. Conclusion. A higher cord serum level of IgM anti-PC is associated with a lower risk of bacterial infections in neonates.

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Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation

Frostegård

2022

Expert Review of Clinical Immunology

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Role of Phosphorylcholine-Specific Immunoglobulin M in Acute Upper Respiratory Tract Infections

Cited by 3 publications

References 20 publications

Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases

Antibodies against Phosphorylcholine—Implications for Chronic Inflammatory Diseases

Associations between cord serum antibodies against phosphorylcholine and bacterial infections in neonates: a prospective cohort study in singletons and twins

Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation

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