Role of photodynamic therapy in unresectable esophageal and lung cancer

Chen, Mang; Pennathur, Arjun; Luketich, James D.

doi:10.1002/lsm.20364

Cited by 31 publications

(16 citation statements)

References 26 publications

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“…2A). Porfimer sodium, a mixture of porphyrin oligomers known under the brand name Photofrin commonly used in the treatment of esophageal and endobronchial cancers21, was also included as a cross-challenging agent to assess the level of cross-resistance. The fluorescence of KP1 and KP6 was strongly reduced in both KP1- and KP6-resistant clones (Fig.…”

Section: Resultsmentioning

confidence: 99%

Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms

Králová

Kolář

Kahle

et al. 2017

Sci Rep

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The development of drug resistance is a major problem which often occurs during anticancer chemotherapies. Photodynamic therapy (PDT) has been studied as an alternative treatment modality for drug-resistant tumors, however the question of resistance to PDT and potential cross-resistance with chemotherapy has yet to be fully answered. To investigate the mechanism of resistance to PDT, we developed an in vitro experimental model system in a mouse mammary carcinoma cell line 4T1. We used two ethylene glycol derivatives of tetraphenylporphyrin, and tetraphenylchlorin derivative, temoporfin, as photosensitizers (PS). PDT-resistant clones were obtained by exposure to a set concentration of PS followed by irradiation with increasing light doses. PDT resistance to soluble glycol porphyrins was mediated mainly by increased drug efflux through ABCB1 (P-glycoprotein) as we demonstrated by specific ABCB1 knockdown experiments, which in turn rescued the sensitivity of resistant cells to PDT. In contrast, resistance raised to temoporfin, which is generally more lipophilic than glycol porphyrins, elicited mechanism based on sequestration of the drug to lysosomes. The resistance that is acquired from a particular PS could be overcome by using a different PS, which is not susceptible to the same mechanism(s) of resistance. Elucidation of the underlying mechanisms in various types of resistance might facilitate improvements in PDT treatment design.

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Section: Resultsmentioning

confidence: 99%

Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms

Králová

Kolář

Kahle

et al. 2017

Sci Rep

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“…This creates tumor necrosis and can be used for superficial lesions as well as bulky tumors. Also in another review by Chen et al from the University of Pittsburgh concluded that PDT is effective in the palliation of lung cancer [74]. This is a well documented treatment modality and has been reported by Moghissi in 1997Moghissi in ,1999 and most recently 2004 [70][71][72].…”

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 96%

A Review of the Use of Stents for Palliation of Esophageal and Lung Cancer

Bizekis¹,

Pass²,

Zervos³

2007

CCTR

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According to the American Cancer Society, there will be an estimated 14,520 new cases of esophageal cancer and 174,470 new cases of lung cancer in 2005 [1]. Close to 60% of these patients with esophageal cancer will present at an advanced stage not amenable to cure, but still will require palliation of their dysphagia [2].Conventional plastic stents (CPS) were used initially, and with continuous improvement in technology, insertion of selfexpanding metal stents (SEMS) has become the palliative treatment of choice in the majority of these patients [3][4][5][6][7]. SEMS are effective in palliating malignant dysphagia in 85%-100% of patients [7][8][9]. More recently, a new selfexpanding plastic stent (SEPS) has been designed which in early studies has been very effective in palliating dysphagia [10][11][12][13].Similarly, the majority of patients with lung cancer will present at an advanced stage and approximately 20% of these patients will have an endobronchial component requiring some form of palliation for relief of airway obstruction [14].Currently airway stents are either made of self-expanding metal for more permanent use, or silicone if a more temporary solution is needed. Complications similar to the esophageal stents may arise.The purpose of this article is to provide an evidence based review of stents in the palliative setting for esophageal and lung cancer and briefly explore their potential use and expanding indications in the neoadjuvant setting.

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“…PDT was first used for lung cancers to achieve tumor necrosis in order to re-open obstructed airways. Now it is associated with improvement in endobronchial obstruction, ventilation and performance status of patients 6-8 weeks after treatment [21].…”

Section: Pdt In Clinical Practicementioning

confidence: 98%

A look at clinical applications and developments of photodynamic therapy

et al. 2008

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The battle against cancer is so important that all possible weapons must be considered. Photodynamic therapy (PDT) is a therapeutic approach which has proved its capacity to give many excellent results, but it is having some difficulty in being imposed. The simplicity of the mechanism of action of this technique has been compromised by the multidisciplinary approach required for its implementation, which makes its adoption for more general use by health professionals difficult. This review aims to give a perspective of the performance of current approved PDT drugs, and their clinical applications against cancer.Basic investigation in PDT, particularly in the design of new sensitizers, is still ongoing, and needs to be further exploited. Emergent and diversified solutions with excellent results in pre-clinical phases are described to raise the multidisciplinary interest required to boost the clinical use of PDT.

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Role of photodynamic therapy in unresectable esophageal and lung cancer

Cited by 31 publications

References 26 publications

Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms

Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms

A Review of the Use of Stents for Palliation of Esophageal and Lung Cancer

A look at clinical applications and developments of photodynamic therapy

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