Role of Photofunctionalization in Mitigating Impaired Osseointegration Associated with Type 2 Diabetes in Rats

Sugita, Yoshihiko; Honda, Yuuma; Kato, Ikuro; Kubo, Katsutoshi; Maeda, Hideaki; Ogawa, Takahiro

doi:10.11607/jomi.3480

Cited by 38 publications

(30 citation statements)

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“…Maintenance of surface hydrophilicity after implant placement is a critical factor during the wound healing and bone formation processes to achieve the most favorable outcome by enhancing interaction between the implant material and host cells. The short photofunctionalization treatment employed here was recently shown to result in accelerated and enhanced osseointegration similar to the longer UV-treatment times employed in earlier studies [29, 37, 38, 43]. …”

Section: Discussionsupporting

confidence: 57%

“…UV irradiation leads to the modification of titanium implant surfaces from a hydrophobic to a superhydrophilic state and removes hydrocarbon contamination [17, 24, 25]. These extreme changes in surface properties have been studied extensively for their effect on enhancing osteoblast attachment and proliferation, which leads to greatly improved osseointegration of titanium implants [26–29]. Despite this very encouraging extensive research regarding bone-implant integration, very little is known to date regarding the effect of photofuntionalization on bacterial attachment and biofilm formation on titanium surfaces despite its importance for lasting implant success [30].…”

Section: Introductionmentioning

confidence: 99%

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Effect of UV-photofunctionalization on oral bacterial attachment and biofilm formation to titanium implant material

Ávila

Lima

Sekiya³

et al. 2015

Biomaterials

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115

105

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Bacterial biofilm infections remain prevalent reasons for implant failure. Dental implant placement occurs in the oral environment, which harbors a plethora of biofilm-forming bacteria. Due to its trans-mucosal placement, part of the implant structure is exposed to oral cavity and there is no effective measure to prevent bacterial attachment to implant materials. Here, we demonstrated that UV treatment of titanium immediately prior to use (photofunctionalization) affects the ability of human polymicrobial oral biofilm communities to colonize in the presence of salivary and blood components. UV-treatment of machined titanium transformed the surface from hydrophobic to superhydrophilic. UV-treated surfaces exhibited a significant reduction in bacterial attachment as well as subsequent biofilm formation compared to untreated ones, even though overall bacterial viability was not affected. The function of reducing bacterial colonization was maintained on UV-treated titanium that had been stored in a liquid environment before use. Denaturing gradient gel-electrophoresis (DGGE) and DNA sequencing analyses revealed that while bacterial community profiles appeared different between UV-treated and untreated titanium in the initial attachment phase, this difference vanished as biofilm formation progressed. Our findings confirm that UV-photofunctionalization of titanium has a strong potential to improve outcome of implant placement by creating and maintaining antimicrobial surfaces.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Effect of UV-photofunctionalization on oral bacterial attachment and biofilm formation to titanium implant material

Ávila

Lima

Sekiya³

et al. 2015

Biomaterials

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115

105

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“…All implants placed in tibias and femurs were unloaded. In detail, most authors reported significantly increased BIC [57,71,[73][74][75][76][77][78][79], push-in values [40,44,[80][81][82][83], bone volume [72,84], or bone mineral [85,86] were noted in all animal models studied for photofunctionalized groups disregarding implant surface modifications/topography. The differences were insignificant for both UV-treated and non-UV-treated reported in four animal studies [87][88][89][90].…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, the UVC light source was from a 15 W bactericidal lamp and exposure time ranging from 2 h to 48 h [72]. Some studies used photo-generated devices (Figure 3), which are available commercially to treat the implant surfaces at chairside, with an exposure time of only around 12-15 min [82,83,90]. The literature search found that several methods have been applied as the source of ultraviolet light with various wavelengths.…”

Section: Mongrel Dogsmentioning

confidence: 99%

An Integrated Overview of Ultraviolet Technology for Reversing Titanium Dental Implant Degradation: Mechanism of Reaction and Effectivity

et al. 2020

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Titanium is widely used as an implanted material in various clinical applications, especially in orthopedics and dental implantology. Following manufacturing and storage, titanium dental implants have the ability to undergo aging, which renders a reduction in osteoblast cellular activity during the healing process, so advancement of a surface treatment to recreate bioactive implant surfaces are required. Ultra-violet (UV) surface treatment has been introduced as a potential solution to reverse the aging process via removal of hydrocarbon contamination on the surface. This narrative review aimed to discuss the current understanding of the mechanism of titanium aging and provide insights into the mechanism that improves the biocompatibility of titanium implants following UV treatment. Additionally, the findings from preclinical and clinical studies is integratively presented. A reference search was performed through the PubMed, Embase, and Scopus databases based on the keywords titanium degradation, titanium aging, photofunctionalization, and UV treatment. Emerging data demonstrated the positive effect of UV light on osteoblast cells with enhanced alkaline phosphatase activity in vitro and increased bone-implant contact in animal studies. Despite limited human studies, the data reported here appear to support the benefit of UV light photofunctionalization on titanium surfaces as an alternative to reverse the titanium aging process. The direction of future research should focus on prospective randomized blinded clinical trials.

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“…[1][2][3][4][5][6][7][8][9][10][11] Implant therapy-related complications such as disability and long-lasting dependence caused by implant loosening remain significant, [11][12][13] and unfavorable anatomical and physiological states of the host bone can preclude implant therapy. [14][15][16][17][18][19][20][21][22] Further, the protracted healing time required by implants to anchor into bone limits the application of implant therapy and reduces therapeutic benefit, particularly for dental implants. All these challenges are partially or largely attributable to the limited capability of implants to integrate with bone.…”

Section: Introductionmentioning

confidence: 99%

Biological and osseointegration capabilities of hierarchically (meso-/micro-/nano-scale) roughened zirconia

Rezaei¹,

Hasegawa²,

Ishijima³

et al. 2018

IJN

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PurposeZirconia is a potential alternative to titanium for dental and orthopedic implants. Here we report the biological and bone integration capabilities of a new zirconia surface with distinct morphology at the meso-, micro-, and nano-scales.MethodsMachine-smooth and roughened zirconia disks were prepared from yttria-stabilized tetragonal zirconia polycrystal (Y-TZP), with rough zirconia created by solid-state laser sculpting. Morphology of the surfaces was analyzed by three-dimensional imaging and profiling. Rat femur-derived bone marrow cells were cultured on zirconia disks. Zirconia implants were placed in rat femurs and the strength of osseointegration was evaluated by biomechanical push-in test.ResultsThe rough zirconia surface was characterized by meso-scale (50 µm wide, 6–8 µm deep) grooves, micro-scale (1–10 µm wide, 0.1–3 µm deep) valleys, and nano-scale (10–400 nm wide, 10–300 nm high) nodules, whereas the machined surface was flat and uniform. The average roughness (Ra) of rough zirconia was five times greater than that of machined zirconia. The expression of bone-related genes such as collagen I, osteopontin, osteocalcin, and BMP-2 was 7–25 times upregulated in osteoblasts on rough zirconia at the early stage of culture. The number of attached cells and rate of proliferation were similar between machined and rough zirconia. The strength of osseointegration for rough zirconia was twice that of machined zirconia at weeks two and four of healing, with evidence of mineralized tissue persisting around rough zirconia implants as visualized by electron microscopy and elemental analysis.ConclusionThis unique meso-/micro-/nano-scale rough zirconia showed a remarkable increase in osseointegration compared to machine-smooth zirconia associated with accelerated differentiation of osteoblasts. Cell attachment and proliferation were not compromised on rough zirconia unlike on rough titanium. This is the first report introducing a rough zirconia surface with distinct hierarchical morphology and providing an effective strategy to improve and develop zirconia implants.

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Role of Photofunctionalization in Mitigating Impaired Osseointegration Associated with Type 2 Diabetes in Rats

Cited by 38 publications

References 0 publications

Effect of UV-photofunctionalization on oral bacterial attachment and biofilm formation to titanium implant material

Effect of UV-photofunctionalization on oral bacterial attachment and biofilm formation to titanium implant material

An Integrated Overview of Ultraviolet Technology for Reversing Titanium Dental Implant Degradation: Mechanism of Reaction and Effectivity

Biological and osseointegration capabilities of hierarchically (meso-/micro-/nano-scale) roughened zirconia

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