Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat

Mageed, Sherif S. Abdel; Ammar, Ramy M.; Nassar, Noha N.; Moawad, Helmy; Kamel, Ahmed S.

doi:10.1016/j.neuropharm.2021.108935

Cited by 18 publications

(6 citation statements)

References 65 publications

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“…The gut microbiota is improved by a prebiotic and probiotic-rich diet because prebiotics promote probiotic development [ 47 ]. Pre-probiotics are used in conjunction with other medications to treat obesity-related colitis and hepatic symptoms [ 48 ], skeletal health and immunity [ 49 ], metabolic profile in chronic kidney disease [ 50 ], and psychological outcomes in obese patients [ 51 ]. The control liver showed normal large polygonal cells with prominent round nuclei and eosinophilic cytoplasm, as well as a few spaced hepatic sinusoids arranged in between the hepatic cords and a fine arrangement of Kupffer cells, upon microscopic examination of the histopathological section of the liver (grade 0) ( Figure 3 A and Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

Elebeedy

Ghanem

Saleh

et al. 2022

IJMS

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The increasing prevalence of obesity has become a demanding issue in both high-income and low-income countries. Treating obesity is challenging as the treatment options have many limitations. Recently, diet modification has been commonly applied to control or prevent obesity and its risks. In this study, we investigated novel therapeutic approaches using a combination of a potential probiotic source with prebiotics. Forty-eight adult male Sprague–Dawley rats were selected and divided into seven groups (eight rats per group). The first group was fed a high-fat diet, while the second group was a negative control. The other five groups were orally administered with a probiotic, Lactiplantibacillus plantarum (L. plantarum), and potential prebiotics sources (chia seeds, green tea, and chitosan) either individually or in combination for 45 days. We collected blood samples to analyze the biochemical parameters and dissected organs, including the liver, kidney, and pancreas, to evaluate obesity-related injuries. We observed a more significant decrease in the total body weight by combining these approaches than with individual agents. Moreover, treating the obese rats with this combination decreased serum catalase, superoxide dismutase, and liver malondialdehyde levels. A histopathological examination revealed a reduction in obesity-related injuries in the liver, kidney, and pancreas. Further docking studies indicated the potential role of chia seeds and green tea components in modulating obesity and its related problems. Therefore, we suggest that the daily administration of a pre- and probiotic combination may reduce obesity and its related problems.

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Section: Resultsmentioning

confidence: 99%

In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

Elebeedy

Ghanem

Saleh

et al. 2022

IJMS

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“…The toxic metabolism product of paracetamol, N‐Acetyl‐p‐benzoquinone imine, interferes with mitochondrial respiration 32 . According to a recent ischemic stroke model, paracetamol may have had a neuroprotective role 33 . Decreased nociception potentially also decreases oxygen uptake 34 .…”

Section: Discussionmentioning

confidence: 99%

“… 32 According to a recent ischemic stroke model, paracetamol may have had a neuroprotective role. 33 Decreased nociception potentially also decreases oxygen uptake. 34 Although paracetamol at low doses has experimentally been shown to have a protective effect in the brain, there is no evidence that its effect on the central nervous system decreases oxygen requirements.…”

Section: Discussionmentioning

confidence: 99%

Paracetamol preceding very preterm birth: Is it safe?

Laitala

Saarela

Vääräsmäki

et al. 2022

Acta Obstet Gynecol Scand

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Introduction:The use of paracetamol for pain relief in pregnancy is common.However, the influence of paracetamol on the perinatal adaptation of high-risk infants has not been studied. These data are important for safety, since another inhibitor of prostaglandin synthesis is harmful to infants born very preterm and increases serious morbidity. We studied whether the use of paracetamol had an adverse influence on neonatal adaptation and the outcomes of infants during the first hospitalization.

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“…On day 14, the last day of the study, the rats were euthanized by decapitation under anaesthesia, using thiopental (50 mg/kg), and the wound granulation tissues produced were removed for further investigation. Buffered formalin was used for H&E staining and histopathological examination, while a phosphate buffer solution was used for biochemical assessment [ 72 ].…”

Section: Methodsmentioning

confidence: 99%

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

et al. 2023

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Glycyrrhiza glabra and Sophora japonica (Fabaceae) are well-known medicinal plants with valuable secondary metabolites and pharmacological properties. The flavonoid-rich fractions of G. glabra roots and S. japonica leaves were prepared using Diaion column chromatography, and the confirmation of flavonoid richness was confirmed using UPLC-ESI-MS profiling and total phenolics and flavonoids assays. UPLC-ESI-MS profiling of the flavonoid-rich fraction of G. glabra roots and S. japonica leaves resulted in the tentative identification of 32 and 23 compounds, respectively. Additionally, the wound healing potential of topical preparations of each fraction, individually and in combination (1:1) ointment and gel preparations, were investigated in vivo, supported by histopathological examinations and biomarker evaluations, as well as molecular docking studies for the major constituents. The topical application of G. glabra ointment and gel, S. japonica ointment and gel and combination preparations significantly increase the wound healing rate and the reduction of oxidative stress in the wound area via MDA reduction and the elevation of reduced GSH and SOD levels as compared to the wound and Nolaver®-treated groups. The molecular docking study revealed that that major compounds in G. glabra and S. japonica can efficiently bind to the active sites of three proteins related to wound healing: glycogen synthase kinase 3-β (GSK3-β), matrix metalloproteinases-8 (MMP-8) and nitric oxide synthase (iNOS). Consequently, G. glabra roots and S. japonica leaves may be a rich source of bioactive metabolites with antioxidant, anti-inflammatory and wound healing properties.

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Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat

Cited by 18 publications

References 65 publications

In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

Paracetamol preceding very preterm birth: Is it safe?

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies

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