Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion

Mukhomedzyanov, A. V.; Popov, Sergey; Маслов, Л Н; Diez, Emiliano; Azev, Vyacheslav N.

doi:10.1007/s10517-023-05801-6

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The Role Of δ-Opioid Receptors and The Transactivation Of Eg...1

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2023

2024

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“…It has been shown that the stimulation of both δ 1 -OR and δ 2 -OR before coronary artery occlusion increases the cardiac tolerance to ischemia/reperfusion (I/R) [16][17][18]. It should be noted that Gross's group used the non-peptide δ 1 -OR agonist TAN-67 for the stimulation of δ 1 -OR at a dose of 10 mg/kg intravenously [18,19], which is apparently sufficient to stimulate the central δ 1 -OR. This group did not use naloxone methiodide, an OR blocker that does not cross the BBB, so it remains unclear whether peripheral or central ORs are involved in the infarct-reducing effect of TAN-67 [20,21].…”

Section: The Role Of δ-Opioid Receptors and The Transactivation Of Eg...mentioning

confidence: 99%

δ-Opioid Receptor as a Molecular Target for Increasing Cardiac Resistance to Reperfusion in Drug Development

et al. 2023

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An analysis of published data and the results of our own studies reveal that the activation of a peripheral δ2-opioid receptor (δ2-OR) increases the cardiac tolerance to reperfusion. It has been found that this δ2-OR is localized in cardiomyocytes. Endogenous opioids are not involved in the regulation of cardiac resistance to reperfusion. The infarct-limiting effect of the δ2-OR agonist deltorphin II depends on the activation of several protein kinases, including PKCδ, ERK1/2, PI3K, and PKG. Hypothetical end-effectors of the cardioprotective effect of deltorphin II are the sarcolemmal KATP channels and the MPT pore.

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