Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
Julian Maggio,
Romina Armando,
Lara Balcone
et al.
Abstract:Peptidyl-prolyl isomerase NIMA-interacting 1 (PIN1) plays a crucial regulatory role in cells, and it is the only enzyme capable of selectively binding to phosphorylated proline-directed serine/threonine (pSer/Thr-Pro) residues in target proteins and catalyzing their isomerization. The change in the conformational status of the protein, transitioning between cis and trans, affects its three-dimensional structure and, therefore, alters its function and stability. In this manner, PIN1 plays a role in the developm… Show more
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