Role of pituitary dysfunction on cardiovascular risk in primary empty sella patients

Colao, Annamaria; Cotta, Oana Ruxandra; Ferone, Diego; Torre, Maria Luisa; Ferraú, Francesco; Somma, Carolina Di; Boschetti, Mara; Teti, Claudia; Savanelli, Maria Cristina; Alibrandi, Angela; Trimarchi, Francesco; Cannavò, Salvatore

doi:10.1111/cen.12122

Cited by 15 publications

(26 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gonadotropin deficiency was predominantly pituitary hormone deficiency, consistent with previous study [3]. However, GH deficiency was most frequent in pituitary hormone deficiency [4,6,7,11,13,16,19,28].…”

Section: Discussionsupporting

confidence: 90%

“…The common causes of PI are pituitary adenoma and peripituitary tumors [1][2][3]. Other causes include pituitary apoplexy, postpartum pituitary necrosis [Sheehan's syndrome (SS)], empty sella, stroke, traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), and lymphocytic hypopituitarism [1][2][3][4][5][6][7][8][9]. Primary empty sella (PES) is defined as the thinning of the pituitary gland after subarachnoid space herniated into the sella turcica in patients with no history of pituitary tumor, radiotherapy, and surgery [4][5][6]10].…”

Section: Introductionmentioning

confidence: 99%

“…This might be associated with delays in the diagnosis of PI because the initial symptoms are generally mild and nonspecific [1,16]. PI is associated increased mortality and morbidity, mainly due to the cardiovascular diseases caused by growth hormone (GH) deficiency [1,4,[15][16][17][18]. Thus, the accurate early diagnosis of PI is important in long-term treatment and follow-up.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical evaluation of pituitary insufficiency in adult population

et al. 2020

View full text Add to dashboard Cite

Background/aim: This retrospective study aimed to investigate the clinical profile of pituitary insufficiency (PI) in adult population. Materials and methods: One hundred and fifty patients who were diagnosed as having PI between 2012 and 2018 (53.3% female, mean age 48.13 ± 15.83 years) were retrospectively analyzed. Results: Age at diagnosis was higher in females as compared with males (51.13 ± 15.95 vs. 44.70 ± 15.08 years, P = 0.012). The most frequent presenting signs were headache (29.4%) and visual disturbance (19.6%) in general. Females frequently presented with headache (33.3%), whereas males presented with sexual dysfunction (34.4%). The most frequent cause of PI was nonfunctional pituitary adenoma (28.8%) in general population. A frequent cause of PI was Sheehan's syndrome (33.8%) among females and nonfunctional pituitary adenoma (38.6%) among males. Pituitary macroadenoma (75.8%) was frequent in pituitary tumors with PI. 55.3 % of the patients had 4 pituitary hormones deficiencies and 26.0% of patients had 3 pituitary hormones deficiencies. Gonadotropin deficiency was the leading pituitary hormone deficiency. The frequency of posttraumatic PI was 4.7% in the general population. Conclusion: Nonfunctional pituitary adenoma was the most common cause of PI among males and Sheehan's syndrome was a major etiologic factor in females. Sheehan's syndrome remains an important health problem in Turkey although obstetric care has improved. Posttraumatic PI should be considered in the differential diagnosis of idiopathic PI.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical evaluation of pituitary insufficiency in adult population

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Hypopituitarism, and in particular GHD are associated with several metabolic alterations and cardiovascular risk [6][7][8]17,[23][24][25][26].This brief report showed that also in hypopituitarism due to TBI metabolic impairment is frequent, in particular altered glucose levels, insulin resistance and dyslipidemia, independently by BMI.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, interaction with untreated hypogonadism cannot be ruled out because only 2 patients received appropriate replacement therapy. Conversely, hypothyroidism and hypocortisolism were under treatment in all patients when metabolic evaluations were performed, although a role of these deficits has been reported in hypopituitarism due to primary empty sella [26].…”

Section: Discussionmentioning

confidence: 99%

Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism

Prodam

Gasco

Caputo

et al. 2013

Growth Hormone & IGF Research

View full text Add to dashboard Cite

Clinical outcome and evidence of high rate post-surgical anterior hypopituitarism in a cohort of TSH-secreting adenoma patients: Might somatostatin analogs have a role as first-line therapy?

et al. 2014

View full text Add to dashboard Cite

Neurosurgery ultimately led to complete disease remission or to biochemical control in majority of patients, whereas resulting in a considerable percentage of post-operative complications (mainly hypopituitarism, 50%). In the light of the optimal results unanimously reported for medical treatment with SSA, our experience suggests that a careful evaluation of risk/benefit ratio should be taken into consideration when directing the treatment approach in patients with TSHoma.

show abstract

Role of pituitary dysfunction on cardiovascular risk in primary empty sella patients

Abstract: Primary empty sella patients show increased cardiovascular risk, regardless of BMI. A worse lipid and glucose profile and higher FS were associated with secondary hypothyroidism, even subclinical, as well as hypogonadism.

Cited by 15 publications

References 30 publications

Clinical evaluation of pituitary insufficiency in adult population

Clinical evaluation of pituitary insufficiency in adult population

Metabolic alterations in patients who develop traumatic brain injury (TBI)-induced hypopituitarism

Clinical outcome and evidence of high rate post-surgical anterior hypopituitarism in a cohort of TSH-secreting adenoma patients: Might somatostatin analogs have a role as first-line therapy?

Contact Info

Product

Resources

About