Role of pituitary stalk and gland radiological status on endocrine function and outcome after endoscopic transsphenoidal surgery for non-functioning pituitary adenomas

Sánchez, Catalina Vivancos; Flores, Alexis Palpán; Domínguez, Víctor Rodríguez; Pérez, Ana Coca; Álvarez-Escolá, Cristina; Lopez, Christine

doi:10.1007/s12020-021-02726-w

Cited by 4 publications

(6 citation statements)

References 32 publications

(34 reference statements)

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“…With the development of artificial intelligence and data science, many studies have used radiomics methods or machine learning to predict the recurrence of brain tumors (18,21,22). However, models built by those methods lack universality between different study centers due to the heterogeneity of data collection, which is the key to the accuracy of model building.…”

Section: Discussionmentioning

confidence: 99%

Prediction of the Recurrence of Non-Functioning Pituitary Adenomas Using Preoperative Supra-Intra Sellar Volume and Tumor-Carotid Distance

et al. 2021

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BackgroundCurrently, it is difficult to estimate the possibility of recurrence of nonfunctioning pituitary adenomas (NFPAs). Markers such as Ki-67 or transcription factors rely on postoperative pathology, while few indices can be used for preoperative prediction. Therefore, we aimed to investigate the predictive effectiveness of supra-intrasellar volume and tumor-carotid distance based on measurements derived from preoperative magnetic resonance imaging (MRI) data.MethodNinety-eight cases of NFPAs were evaluated, along with their clinical characteristics and MRI features. Four radiologic indices were analyzed, including intrasellar tumor volume, suprasellar tumor volume, maximum horizontal tumor diameter, and intercarotid distance. The ratio of supra-intrasellar volume and ratio of tumor-carotid distance were measured using 3D Slicer software, and the sum of two ratios was defined as the V-D value. The correlation between recurrence and multiple factors was analyzed using univariate and multivariate logistic regression and Kaplan-Meier analysis, and ROC curves were used to estimate the prognostic performance of radiologic measurements in NFPAs.ResultThe supra-intrasellar volume ratio, tumor-carotid distance ratio and V-D value were significantly correlated with the recurrence of NFPAs. The predictive importance of the V-D value reached 84.5%, with a sensitivity of 83.7% and specificity of 67.3%. The cutoff limit of the V-D value was 1.53, and patients with V-D values higher than 1.53 tended to relapse much earlier.ConclusionThe V-D value has predictive importance for the recurrence of NFPAs preoperatively. Patients with higher V-D values will undergo recurrence earlier and should be given greater consideration in terms of surgery and follow-up time.

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Section: Discussionmentioning

confidence: 99%

Prediction of the Recurrence of Non-Functioning Pituitary Adenomas Using Preoperative Supra-Intra Sellar Volume and Tumor-Carotid Distance

et al. 2021

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“…This is compared to dogs with nonfunctional pituitary tumors being diagnosed later in the disease process after the development of clinical signs of mass effect in the brain 17 . This presentation and timing of diagnosis is similar in humans 5–7,26,27 . Rijn et al found that with increasing surgical experience, TSH remains an option for dogs with PDH and large pituitary tumors 31…”

Section: Discussionmentioning

confidence: 99%

“…17 This presentation and timing of diagnosis is similar in humans. [5][6][7]26,27 Rijn et al found that with increasing surgical experience, TSH remains an option for dogs with PDH and large pituitary tumors. 31 Sato et al determined that dogs with functional pituitary tumors of type A, grade 1 to 3 had a good prognosis following TSH and that dogs with grade 3B, 4 and 5 may not be suitable for TSH.…”

Section: Discussionmentioning

confidence: 99%

“…Nonfunctional sellar masses (NFSM) are tumors that do not secrete a sufficient concentration of hormone for detection in the blood or result in endocrine symptoms 2,4–5 . As a consequence of hormonal inactivity, patients typically present with large tumors that cause neurological symptoms of mass effect such as headache, vision loss, or hypopituitarism 1–3,5–7 . Surgical resection in humans remains the treatment of choice for nonfunctional pituitary adenoma (NFPA) exerting significant mass effect 2,6,8 .…”

Section: Introductionmentioning

confidence: 99%

“… 2 , 4 , 5 As a consequence of hormonal inactivity, patients typically present with large tumors that cause neurological symptoms of mass effect such as headache, vision loss, or hypopituitarism. 1 , 2 , 3 , 5 , 6 , 7 Surgical resection in humans remains the treatment of choice for nonfunctional pituitary adenoma (NFPA) exerting significant mass effect. 2 , 6 , 8 Surgery is infrequently curative due to supra or parasellar extension.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and outcome in 15 dogs treated with transsphenoidal hypophysectomy for nonfunctional sellar masses

et al. 2022

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Objective: To characterize the clinical features, neurological examination findings, diagnostic imaging results, histopathological findings, and outcome following transsphenoidal hypophysectomy (TSH) in dogs with nonfunctional sellar masses (NFSM).Study design: Multi-institutional retrospective study.Methods: Medical records of dogs that underwent TSH for a NFSM were reviewed for clinical signs, physical and neurological examination findings, diagnostic imaging results, endocrine testing, surgery reports, and outcome. Magnetic resonance (MR) imaging was rereviewed, and tumors were classified using the previously described system according to pituitary tumor extension and vascular involvement. Owners of dogs that survived to discharge were contacted. Results: The majority of dogs presented for mentation change (12/15). The mean pituitary to brain ratio (P/B ratio) was 1.05 (0.6-1.4). Eight dogs had a tumor imaging classification of 5B. Eleven dogs were diagnosed with a nonfunctional pituitary adenoma (NFPA). Perioperative mortality was 33% (5/15). The median survival for all dogs was 232 days (0-1658). When dogs that did not survive to discharge were excluded, the median survival time was 708 days.

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Evaluation of Retrospective Patient Preference on Extent of Resection of Nonfunctioning Pituitary Adenomas

Behzadi,

Ruiz,

Tran

et al. 2024

World Neurosurgery

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Role of pituitary stalk and gland radiological status on endocrine function and outcome after endoscopic transsphenoidal surgery for non-functioning pituitary adenomas

Cited by 4 publications

References 32 publications

Prediction of the Recurrence of Non-Functioning Pituitary Adenomas Using Preoperative Supra-Intra Sellar Volume and Tumor-Carotid Distance

Prediction of the Recurrence of Non-Functioning Pituitary Adenomas Using Preoperative Supra-Intra Sellar Volume and Tumor-Carotid Distance

Clinical characteristics and outcome in 15 dogs treated with transsphenoidal hypophysectomy for nonfunctional sellar masses

Evaluation of Retrospective Patient Preference on Extent of Resection of Nonfunctioning Pituitary Adenomas

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