Role of Plantaricin in Treatment of UTIs in Female Rats

Abstract

HE purpose of the present research is to investigation of plantaricin against urinary tract infection that induced by E.coli O157H7 in female rats , which consisted of two steps; the first included isolation and identification of E.coli O157 H7 by using biochemical tests and VITEK II system, while the second step is studying the therapeutic activity of plantaricin (which isolate from Lactobacillus plantarum and identified genetically by PCR) against the UTIs that induced experimentally by E.coli O157:H7 in 32 female rats (which are divided into four equal groups), and comparison of these effects with ciprofloxacin. The results of this research showed that plantaricin has a clear therapeutic effect in the treatment of UTIs through its effect on body weight and improved clinical markers as well as urine bacterial count and level of creatinine in serum of female rats that compared to animals, were more heavily infected with E. coli O 157;H7 that have been infected with E.coli O157:H7 and not been treated or with animals that treated with ciprofloxacin. This antibacterial activity that characterizes the plantaricin due to natural and safe antimicrobial effects against pathogenic E. coli O157:H7.