Role of plasma membrane disruption in reference moist smokeless tobacco-induced cell death

Joyce, Andrew; Hawkins, William; Fariss, Marc W.; Sengupta, Tapas K.

doi:10.1016/j.toxlet.2010.06.014

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…While in vitro studies have been performed examining the toxicological implications of a variety of ST products [34,35,36] and in vivo animal systems have examined the effects of ST via food or drinking water [31,37,38], oral mucosal absorption of ST, that most closely reflects the human ST experience, has not yet been studied. Another strength of this study is the inclusion of nicotine alone into the experimental design (at approximately the same circulating cotinine level as that produced by gutkha) that serves to both gauge effects of gutkha compared to a known tobacco toxicant and aids in identifying key components that may contribute to the observed effects.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Gutkha, a Smokeless Tobacco Product Gone Global: Is There More to the Toxicity than Nicotine?

Willis¹,

Popovech²,

Gany

et al. 2014

IJERPH

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The popularity of smokeless tobacco (ST) is growing rapidly and its prevalence of use is rising globally. Consumption of Gutkha, an addictive form of ST, is particularly common amongst South Asian communities throughout the World. This includes within the US, following large-scale immigration into the country. However, there exists a lack of knowledge concerning these alternative tobacco products. To this end, a study was carried out to determine the toxicity of gutkha, and what role, if any, nicotine contributes to the effects. Adult male mice were treated daily for 3-week (5 day/week, once/day), via the oral mucosa, with equal volumes (50 μL) of either sterile water (control), a solution of nicotine dissolved in water (0.24 mg of nicotine), or a solution of lyophilized guthka dissolved in water (21 mg lyophilized gutkha). Serum cotinine, measured weekly, was 36 and 48 ng/mL in gutkha- and nicotine-treated mice, respectively. Results demonstrated that exposure to nicotine and gutkha reduced heart weight, while exposure to gutkha, but not nicotine, decreased liver weight, body weight, and serum testosterone levels (compared to controls). These findings suggest that short-term guhtka use adversely impacts growth and circulating testosterone levels, and that gutkha toxicity may be driven by components other than nicotine. As use of guthka increases worldwide, future studies are needed to further delineate toxicological implications such that appropriate policy decisions can be made.

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Section: Discussionmentioning

confidence: 99%

Toxicity of Gutkha, a Smokeless Tobacco Product Gone Global: Is There More to the Toxicity than Nicotine?

Willis¹,

Popovech²,

Gany

et al. 2014

IJERPH

View full text Add to dashboard Cite

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Evaluation of cytotoxicity of different tobacco product preparations

Arimilli

Damratoski

Bombick

et al. 2012

Regulatory Toxicology and Pharmacology

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Plasma membrane integrity: implications for health and disease

2021

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Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment. To avoid lethal consequences, cells are equipped with repair pathways to restore membrane integrity. Here, we assess plasma membrane damage and repair from a whole-body perspective. We highlight the role of tissue-specific stressors in health and disease and examine membrane repair pathways across diverse cell types. Furthermore, we outline the impact of genetic and environmental factors on plasma membrane integrity and how these contribute to disease pathogenesis in different tissues.

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Role of plasma membrane disruption in reference moist smokeless tobacco-induced cell death

Cited by 3 publications

References 45 publications

Toxicity of Gutkha, a Smokeless Tobacco Product Gone Global: Is There More to the Toxicity than Nicotine?

Toxicity of Gutkha, a Smokeless Tobacco Product Gone Global: Is There More to the Toxicity than Nicotine?

Evaluation of cytotoxicity of different tobacco product preparations

Plasma membrane integrity: implications for health and disease

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