Role of platelet-derived growth factor in type II diabetes mellitus                     and its complications

Shen, Sihong; Wang, Fuyan; Fernandez, Alejandra; Hu, Weining

doi:10.1177/1479164120942119

Cited by 35 publications

(36 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PDGF receptor is a membrane glycoprotein that is distributed in many cells, such as ovarian foam cells and granulosa cells, fibroblasts, glial cells, smooth muscle cells, lipid storage cells, osteoblasts, endothelial cells, and so on. PDGF is present in granulosa cells of follicles, as well as in ova and antral follicles [19,20]. PDGF stimulates the growth of vesicle membrane cells and inhibits the secretion of progesterone and androstenedione stimulated by luteinizing hormone (LH).…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of PDGF, EGF, and sFlt-1 in Patients with Polycystic Ovary Syndrome and Their Predictive Effects on Pregnancy Outcomes

Gao

Song

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a neuroendocrine disease with complex etiology characterized by infrequent menstruation, follicular developmental disorders, insulin resistance, and hyperandrogenism. PCOS patients often suffer from anovulatory infertility, and even after successful pregnancy promotion, spontaneous abortion is easy to occur. At present, PCOS is mainly diagnosed by auxiliary examinations such as sex hormones and B ultrasonography, and there is a lack of specific serological markers for the diagnosis of diseases. Similarly, there is a lack of effective evaluation methods for the risk of abortion in PCOS patients. Therefore, it is extremely important to explore the factors that affect the occurrence of abortion in PCOS patients and to find specific indicators that can guide the pregnancy outcome of PCOS patients. The purpose of this study was to investigate the serum levels of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) in PCOS patients and analyze their predictive effects on the pregnancy outcomes of PCOS patients. The results showed that serum PDGF, EGF, and sFlt-1 levels were secreted abnormally in PCOS patients with abortion and were closely related to the pregnancy outcome of PCOS patients. The combination of the three levels has the highest value in predicting the pregnancy outcome of PCOS patients, which is worth promoting.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum Levels of PDGF, EGF, and sFlt-1 in Patients with Polycystic Ovary Syndrome and Their Predictive Effects on Pregnancy Outcomes

Gao

Song

Wang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Decreased plasma IL22 level was found to be a potential trigger of impaired fasting glucose and type 2 diabetes, in a retrospective study of Han Chinese subjects [30]. PDGFBB is reported associate with Type 2 diabetes mellitus and complications [31,32]. TGFA [33] and TGFB [34] have shown pathologic contribution in diabetic kidney disease.…”

Section: Discussionmentioning

confidence: 94%

Temporal response characterization across individual multiomics profiles of prediabetic and diabetic subjects

Min

Piermarocchi

Mias

2021

Preprint

View full text Add to dashboard Cite

Longitudinal deep multi-omics profiling, which combines biomolecular, physiological, environmental and clinical measures data, shows great promise for precision health. However, integrating and understanding the complexity of such data remains a big challenge. Here we propose a bottom-up framework starting from assessing single individuals' multi-omics time series, and using individual responses to assess multi-individual grouping based directly on similarity of their longitudinal deep multi-omics profiles. We applied our method to individual profiles from a study profiling longitudinal responses in type 2 diabetes mellitus. After generating periodograms for individual subject omics signals, we constructed within-person omics networks and analyzed personal-level immune changes. The results showed that our method identified both individual-level responses to immune perturbation, and the clusters of individuals that have similar behaviors in immune response and which was associated to measures of their diabetic status.

show abstract

“…Currently, genetically modified MSCs are more commonly used to increase the efficacy and therapeutic potential of stem cells in Help to promote the viability of pericytes thus reducing loss of pericytes (early sign of DR), however it also may promote angiogenesis which is detrimental in DR. (72,73,74) Angiopoietin-1 (Ang-1) Reduce pericytes apoptosis, help to tightens the endothelial cell junction, thus reduce vascular permeability, inhibition of abnormal angiogenesis.…”

Section: Genetically Modified Stem Cells To Treat Diabetic Retinopathymentioning

confidence: 99%

Genetic Modification as a New Approach to Ameliorate the Therapeutic Efficacy of Stem Cells in Diabetic Retinopathy

Hakim

Noble

Thomas

et al. 2022

European Journal of Ophthalmology

View full text Add to dashboard Cite

Over the last decades, the strategy of using stem cells has gained a lot of attention in treating many diseases. Recently, DR was identified as one of the common complications experienced by diabetic patients around the world. The current treatment strategy needs to be addressed since the active progression of DR may lead to permanent blindness. Interestingly, varieties of stem cells have emerged to optimize the therapeutic effects. It is also known that stem cells possess multilineage properties and are capable of differentiating, expanding in vitro and undergoing genetic modification. Moreover, modified stem cells have shown to be an ideal resource to prevent the degenerative disease and exhibit promising effects in conferring the migratory, anti-apoptotic, anti-inflammatory and provide better homing for cells into the damaged tissue or organ as well promoting healing properties. Therefore, the understanding of the functional properties of the stem cells may provide the comprehensive guidance to understand the manipulation of stem cells making them useful for long-term therapeutic applications. Hence in this review the potential use and current challenges of genetically modified stem cells to treat DR will be discussed along with its future perspectives.

show abstract

Role of platelet-derived growth factor in type II diabetes mellitus and its complications

Cited by 35 publications

References 73 publications

Serum Levels of PDGF, EGF, and sFlt-1 in Patients with Polycystic Ovary Syndrome and Their Predictive Effects on Pregnancy Outcomes

Serum Levels of PDGF, EGF, and sFlt-1 in Patients with Polycystic Ovary Syndrome and Their Predictive Effects on Pregnancy Outcomes

Temporal response characterization across individual multiomics profiles of prediabetic and diabetic subjects

Genetic Modification as a New Approach to Ameliorate the Therapeutic Efficacy of Stem Cells in Diabetic Retinopathy

Contact Info

Product

Resources

About