Role of platelet infiltration as independent prognostic marker for gastric adenocarcinomas

Wang, Jing; Zhang, Miao; Zhou, Ting; Zhao, Sixiang; Su, Zhenguo; Liu, Xiangdong

doi:10.1002/jcla.23320

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Previously, several investigations have found that platelet count is an independent factor affecting the survival rate of patients with refractory ascites. 26 Therefore, PLT count is related to postoperative liver function and survival rate, and a higher PLT count is beneficial to liver function. 27 In the present study, miR-9a-5p had the highest AUC value in patients with relapse.…”

Section: A B Cmentioning

confidence: 99%

Expression of miR-9a-5p in cirrhosis patients with recurrent portal hypertension after treatment

Nie

Meng

et al. 2021

Adv Clin Exp Med

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Background. MicroRNA (miR) influences the biological activities of cirrhotic patients with recurrent portal hypertension.Objectives. The current study was designed to investigate risk factors related to the survival of cirrhosis patients and assessed the possibility of using miR-9a-5p predictability to prevent post-treatment portal hypertension. Materials and methods.Patients with portal hypertension due to liver cirrhosis treated from January 2015 to September 2016 were included in this study. Patients without relapse after treatment were selected as the success group while patients with relapse after treatment were selected as the recurrence group. Serum samples from healthy people were also collected. The blood indexes of the 2 groups of patients before and after treatment were compared and the miR-9a-5p serum level in each group was determined. The Kaplan-Meier method was applied to analyze three-year survival, Cox univariate regression was used to analyze the risk factors for recurrence of cirrhotic portal hypertension, and the receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of serum miR-9a-5p, total bilirubin (TBIL) and platelet (PLT) levels in patients with recurrence.Results. The miR-9a-5p level in the recurrence group was higher than that in the success group after treatment. In patients with recurrence, the miR-9a-5p level was negatively correlated with red blood cell count, TBIL, white blood cell count, and PLT count, and positively correlated with albumin. The miR-9a-5p, TBIL and PLT are potential markers of recurrent portal hypertension in liver cirrhosis. The miR-9a-5p had the highest area under the curve (AUC) value in patients with relapse. Conclusions.The miR-9a-5p is a risk factor for the recurrence of cirrhotic portal hypertension after treatment. It may be used as a marker of recurrence, and so has potential clinical value for the diagnosis and treatment of recurrent portal hypertension.

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Section: A B Cmentioning

confidence: 99%

Expression of miR-9a-5p in cirrhosis patients with recurrent portal hypertension after treatment

Nie

Meng

et al. 2021

Adv Clin Exp Med

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“…[9][10][11] On the other hand, various tumors have been reported to be closely related to systemic immune status and coagulation, including fibrinogen (FIB), albumin, pre-albumin, platelets, etc. [12][13][14] It has been shown that reduced levels of albumin and prealbumin in the body will lead to a reduced nutritional status and impaired immune function in patients, thus promoting tumour progression. 15,16 FIB increases during tumour development, promoting platelet adhesion and binding to growth factors, accelerating tumour cell adsorption and metastasis.…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Fibrinogen and Platelet to Pre-Albumin Ratio in Predicting the Prognosis of Advanced Gastric Cancer

Tian,

Liu,

Zhang

et al. 2023

JIR

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Objective The aim of this study was to investigate the clinical significance of Fibrinogen and Platelet to Pre-albumin Ratio(FPAR) in predicting the prognosis of patients with advanced gastric cancer(AGC) and to construct a predictive model. Methods We collected clinical data from 489 postoperative patients with AGC. FPAR was divided into high and low groups according to the receiver operating characteristic (ROC) curve. The value of FPAR in predicting the prognosis of progressive gastric cancer was analysed using univariate and multivariable Cox regression analysis and its relationship with clinicopathological features. Finally, the Overall Survival(OS) and recurrence-free survival(RFS) prediction models were constructed and validated using FPAR. Results Univariate and multifactorial cox regression analysis showed that grade (P<0.001), TNM-stage (P<0.001), chemotherapy (P<0.001), and FPAR (OR=3.054,95% CI:2.088–4.467, P<0.001) were independent risk factors for OS; grade (P=0.021), N-stage (P=0.024), TNM-stage (P=0.033), and FPAR (OR=2.215,95% CI:1.634–3.003, P<0.001) were independent risk factors for RFS. Subgroup analysis showed that the FPAR-low group had higher OS and RFS than the FPAR-high group, regardless of the patient’s TNM stage (p<0.05). However, OS was instead higher in the the stage III-FPAR-low group than in the the stage II-FPAR-high group (p<0.05), while RFS was not significantly different. Predictive models incorporating FPAR had better predictive performance than those without FPAR, showing wide range of net benefit and AUC. After correction, the 2-year AUC, 3-year AUC and C-index of the OS model were 0.737, 0.756, and 0.746; the 2-year AUC, 3-year AUC, and C-index of the RFS model were 0.738, 0.758, and 0.711. Conclusion FPAR levels were associated with prognosis in patients with AGC and could independently predict RFS and OS.

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“…Studies have indicated that platelet (PLT) regulates tumorigenesis and tumor progression, such as GC, prostate cancer, lung cancer, breast cancer, and colorectal cancer etc ( Oh et al, 2019 ; Garmi et al, 2020 ; Meikle et al, 2020 ; Plantureux et al, 2020 ; Rudzinski et al, 2020 ; Singla et al, 2020 ; Wang et al, 2020 ). For examples, PLT directly promote epithelial-mesenchymal transformation (EMT) of malignant tumors by producing TGF-β, leading to poor prognosis ( Labelle et al, 2011 ; Heldin et al, 2012 ; Guo et al, 2019 ; Chong et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Screening and validation of platelet activation-related lncRNAs as potential biomarkers for prognosis and immunotherapy in gastric cancer patients

et al. 2022

Self Cite

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Background: Platelets (PLT) have a significant effect in promoting cancer progression and hematogenous metastasis. However, the effect of platelet activation-related lncRNAs (PLT-related lncRNAs) in gastric cancer (GC) is still poorly understood. In this study, we screened and validated PLT-related lncRNAs as potential biomarkers for prognosis and immunotherapy in GC patients.Methods: We obtained relevant datasets from the Cancer Genome Atlas (TCGA) and Gene Ontology (GO) Resource Database. Pearson correlation analysis was used to identify PLT-related lncRNAs. By using the univariate, least absolute shrinkage and selection operator (LASSO) Cox regression analyses, we constructed the PLT-related lncRNAs model. Kaplan-Meier survival analysis, univariate, multivariate Cox regression analysis, and nomogram were used to verify the model. The Gene Set Enrichment Analysis (GSEA), drug screening, tumor immune microenvironment analysis, epithelial-mesenchymal transition (EMT), and DNA methylation regulators correlation analysis were performed in the high- and low-risk groups. Patients were regrouped based on the risk model, and candidate compounds and immunotherapeutic responses aimed at GC subgroups were also identified. The expression of seven PLT-related lncRNAs was validated in clinical medical samples using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).Results: In this study, a risk prediction model was established using seven PLT-related lncRNAs -(AL355574.1, LINC01697, AC002401.4, AC129507.1, AL513123.1, LINC01094, and AL356417.2), whose expression were validated in GC patients. Kaplan-Meier survival analysis, the receiver operating characteristic (ROC) curve analysis, univariate, multivariate Cox regression analysis verified the accuracy of the model. We screened multiple targeted drugs for the high-risk patients. Patients in the high-risk group had a poorer prognosis since low infiltration of immune killer cells, activation of immunosuppressive pathways, and poor response to immunotherapy. In addition, we revealed a close relationship between risk scores and EMT and DNA methylation regulators. The nomogram based on risk score suggested a good ability to predict prognosis and high clinical benefits.Conclusion: Our findings provide new insights into how PLT-related lncRNAs biomarkers affect prognosis and immunotherapy. Also, these lncRNAs may become potential biomarkers and therapeutic targets for GC patients.

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Role of platelet infiltration as independent prognostic marker for gastric adenocarcinomas

Cited by 5 publications

References 18 publications

Expression of miR-9a-5p in cirrhosis patients with recurrent portal hypertension after treatment

Expression of miR-9a-5p in cirrhosis patients with recurrent portal hypertension after treatment

Clinical Significance of Fibrinogen and Platelet to Pre-Albumin Ratio in Predicting the Prognosis of Advanced Gastric Cancer

Screening and validation of platelet activation-related lncRNAs as potential biomarkers for prognosis and immunotherapy in gastric cancer patients

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