Role of platelets on liver regeneration after 90% hepatectomy in mice

Myronovych, Andriy; Murata, Soichiro; Chiba, Mitsuru; Matsuo, Ryota; Ikeda, Osamu; Watanabe, Motonobu; Hisakura, Katsuji; Nakano, Yoritaka; Kohno, Keisuke; Kawasaki, Takuya; Hashimoto, Ikuka; Shibasaki, Yuki; Yasue, Hiroshi; Ohkohchi, Nobuhiro

doi:10.1016/j.jhep.2008.04.019

Cited by 103 publications

(101 citation statements)

References 42 publications

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“…Platelets promote hepatocyte proliferation and have an anti-fibrotic effect in vitro (Matsuo et al 2008;Kawasaki et al 2010;Ikeda et al 2011), and thrombocytosis promotes liver regeneration and reduces liver fibrosis in vivo (Murata et al 2007;Murata et al 2008b;Myronovych et al 2008;Watanabe et al 2009). We hypothesized that platelet increment therapy would improve liver function in humans.…”

Section: Discussionmentioning

confidence: 99%

“…When the liver is injured, platelets accumulate in the injured liver and actively translocate into Disse spaces Nakamura 1992, 1993;Nakamura et al 1998;Murata et al 2007;Myronovych et al 2008). The direct contact between platelets and hepatocytes or LSECs is necessary for hepatocyte proliferation (Matsuo et al 2008;Kawasaki et al 2010), and the direct contact between platelets and HSCs is essential for an anti-fibrotic effect (Ikeda et al 2011). Taken together, the previous and current data suggest that transfused platelets delivered to the portal vein accumulate in the damaged liver due to CLD; directly contact hepatocytes, LSECs, and HSCs; and finally improve liver function and reduce liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Orally active thrombopoietin receptor agonist increases platelet count in patients with thrombocytopenia due to hepatitis C virusrelated CLD and cirrhosis (McHutchison et al 2007). Thrombocytosis by administering thrombopoietin improves liver regeneration and reduces liver fibrosis in vivo (Murata et al 2007;Murata et al 2008b;Myronovych et al 2008;Watanabe et al 2009). Therefore, thrombocytosis by administration of thrombopoietin could help sustain the improvement of liver function in patients with CLD and cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

“…They contain various growth factors, such as platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), and transforming growth factor-beta (TGF-β) (Assoian et al 1983;Oka and Orth 1983;Nakamura et al 1986;Miyazono and Takaku 1989), which are required for tissue regeneration. Platelets induce hepatocyte proliferation by releasing HGF and IGF-1 (Matsuo et al 2008). In addition, liver sinusoidal endothelial cells (LSECs), which constitute the sinusoidal wall, are involved in liver regeneration (Malik et al 2002), and platelets stimulate LSECs to promote hepatocyte proliferation (Kawasaki et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, liver sinusoidal endothelial cells (LSECs), which constitute the sinusoidal wall, are involved in liver regeneration (Malik et al 2002), and platelets stimulate LSECs to promote hepatocyte proliferation (Kawasaki et al 2010). Thrombocytosis promotes liver regeneration not only in normal livers but also in fibrotic livers (Murata et al 2007;Murata et al 2008b;Myronovych et al 2008;Watanabe et al 2009). Hepatic stellate cells (HSCs) play a major role in liver fibrosis (Friedman 2008).…”

Section: Introductionmentioning

confidence: 99%

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Platelet Transfusion Improves Liver Function in Patients with Chronic Liver Disease and Cirrhosis

Maruyama

Murata

Takahashi

et al. 2013

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Platelet Transfusion Improves Liver Function in Patients with Chronic Liver Disease and Cirrhosis

Maruyama

Murata

Takahashi

et al. 2013

Tohoku J. Exp. Med.

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Liver regeneration and platelets

Clavien

Graf

2009

British Journal of Surgery

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What is critical for liver surgery and partial liver transplantation

et al. 2010

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Major liver resections and partial orthotopic liver transplantation (OLT) have become established procedures in liver surgery; for many patients, these techniques offer the only curative option.1 Yet, many patients develop postoperative complications because the remnant livers or grafts are too small or of poor quality to sustain sufficient organ function. This somewhat new and poorly defined phenomenon has been termed ''small-for-size syndrome'' (SFSS) to describe this scenario. The concept is, in fact, not a new one, because as early as the 1970s, Thomas E. Starzl described the complicated postoperative course of a young woman subjected to an almost 90% hepatectomy and who was subsequently characterized by prolonged hyperbilirubinemia, encephalopathy, and coagulopathy.2 In an unconventional way for a review, we will start with three case reports to illustrate the scope and clinical relevance of SFSS after liver surgery and transplantation.Case 1: A 47-year-old healthy man, whose wife was listed for OLT due to a symptomatic nonresectable hemangioendothelioma of the liver, offered to be considered for living donor liver transplantation (LDLT). Following the standard work-up for this procedure, he underwent a right hemi-hepatectomy including the middle hepatic vein to serve as allograft for his wife. The remnant left hemi-liver was estimated by computed tomographic (CT) volumetry to weigh 450 g, i.e., around 32% of the whole liver. The ratio of the remnant liver weight to body weight (RLBW) was 0.65%. The donor had a difficult postoperative course developing mild encephalopathy and hyperbilirubinemia lasting 20 days peaking at 178 lmol/L (10.4 mg/ dL) by day five, and severe coagulopathy (prothrombin time <30%) that normalized by day 7. The donor eventually recovered fully, and was discharged in good general condition 22 days after surgery.Case 2: A 42-year-old male was listed for OLT because of Child B cirrhosis (Model for End-Stage Liver Disease [MELD] score: 21) and a small (3 cm) hepatocellular carcinoma (HCC) related to hepatitis B virus infection. He received the right hemi-liver containing the middle hepatic vein from his wife (graft weighing 620 g), who had an uneventful postoperative course. The ratio of graft size in grams to her husband's body weight (80 kg) (graft-to-recipient weight ratio [GRWR]) was 0.7%. The postoperative period was complicated by encephalopathy, hyperbilirubinemia (up to 262 lmol/L, 15.3 mg/dL) for 2 weeks, and prolonged coagulopathy with a factor V level below 20% at day 4. As a result of the delayed graft function, the patient required intensive care unit treatment for 1 week before the liver graft function improved. He was able to be discharged in good general condition on postoperative day 21.Case 3: A 58-year-old male presented with multiple colorectal liver metastases in the right hemi-liver as well as in segment II, III, and 10 months after resection of the primary rectal tumor followed by 5 cycles of chemotherapy containing Folfox and Avastin. A

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Role of platelets on liver regeneration after 90% hepatectomy in mice

Cited by 103 publications

References 42 publications

Platelet Transfusion Improves Liver Function in Patients with Chronic Liver Disease and Cirrhosis

Platelet Transfusion Improves Liver Function in Patients with Chronic Liver Disease and Cirrhosis

Liver regeneration and platelets

What is critical for liver surgery and partial liver transplantation

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