Role of polyamines in the binding of initiator tRNA to the 70S ribosomes of extreme thermophilic bacterium Calderobacterium hydrogenophilum

Mikulı́k, Karel; Andĕrová, Miroslava

doi:10.1007/bf00307772

Cited by 8 publications

(1 citation statement)

References 20 publications

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“…These compounds, particularly polyamines, are known to stabilize nucleic acids in thermophilic cells (see above). Moreover, in the bacterium Calderobacterium hydrogenophilum polyamine compounds stabilize the 70S initiation complex of ribosomes (Mikulik and Anderova 1994). Many temperature studies in the Thermotogae have focused on the accumulation of these organic compounds and polyamines and the elucidation of their biosynthetic pathways in T. maritima and the more moderate thermophile Petrotoga miotherma (Zellner and Kneifel 1993;Jorge et al 2007;Rodrigues et al 2009;Oshima et al 2011;Rodionova et al 2013).…”

Section: Compatible Solutes: the Power Of Redundancymentioning

confidence: 99%

Insights into thermoadaptation and the evolution of mesophily from the bacterial phylum Thermotogae

2015

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Thermophiles are extremophiles that grow optimally at temperatures >45°C. To survive and maintain function of their biological molecules, they have a suite of characteristics not found in organisms that grow at moderate temperature (mesophiles). At the cellular level, thermophiles have mechanisms for maintaining their membranes, nucleic acids, and other cellular structures. At the protein level, each of their proteins remains stable and retains activity at temperatures that would denature their mesophilic homologs. Conversely, cellular structures and proteins from thermophiles may not function optimally at moderate temperatures. These differences between thermophiles and mesophiles presumably present a barrier for evolutionary transitioning between the 2 lifestyles. Therefore, studying closely related thermophiles and mesophiles can help us determine how such lifestyle transitions may happen. The bacterial phylum Thermotogae contains hyperthermophiles, thermophiles, mesophiles, and organisms with temperature ranges wide enough to span both thermophilic and mesophilic temperatures. Genomic, proteomic, and physiological differences noted between other bacterial thermophiles and mesophiles are evident within the Thermotogae. We argue that the Thermotogae is an ideal group of organisms for understanding of the response to fluctuating temperature and of long-term evolutionary adaptation to a different growth temperature range.Key words: lateral gene transfer, Kosmotoga, Mesotoga, thermostability, stress response. Résumé :Les thermophiles sont des extrémophiles dont la température optimale de croissance se situe au-delà de 45°C. Pour survivre et permettre à leurs biomolécules de bien fonctionner, ils doivent se doter de caractéristiques qu'on ne retrouve pas chez des organismes se développant à des températures intermédiaires (mésophiles). Sur le plan cellulaire, les thermophiles ont des mécanismes permettant de préserver leurs membranes, acides nucléiques et autres structures cellulaires. Au chapitre des protéines, chacune d'entre elles demeure stable et active à des températures qui dénatureraient leurs homologues mésophiles. En revanche, les structures et protéines cellulaires des thermophiles pourraient ne pas fonctionner de manière optimale à des températures intermédiaires. De telles différences entre les thermophiles et les mésophiles auraient tendance à se dresser en travers d'une transition évolutive entre ces deux modes de vie. Par conséquent, l'étude de thermophiles et de mésophiles fortement apparentés pourrait nous permettre d'établir comment surviendraient de telles transitions du mode de vie. Le phylum bactérien Thermotogae regroupe des hyperthermophiles, des thermophiles, des mésophiles et des organismes dont l'intervalle de températures chevauche les plages thermophiles et mésophiles. On observe parmi les Thermotogae des différences sur le plan génomique, protéomique, et physiologique qu'on relève également entre d'autres thermophiles et méso-philes bactériens. Nous soutenons que les Thermot...

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Section: Compatible Solutes: the Power Of Redundancymentioning

confidence: 99%

Insights into thermoadaptation and the evolution of mesophily from the bacterial phylum Thermotogae

2015

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Structure, Biological Activity and Synthesis of Polyamine Analogues and Conjugates

Karigiannis

Papaioannou²

2000

Eur. J. Org. Chem.

119

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The structure and the biological significance of naturally occurring and synthetic polyamine analogues and conjugates are presented and the available methodologies for their synthesis are described. These methodologies involve either the selective functionalization of the amino functions, using suitable protecting groups or acylating agents, or fragment synthesis protocols. The latter employ suitable amino components and simple reactions, like Michael addition to α,β‐unsaturated nitriles, alkylation of amines and sulfonamides, reductive alkylation and acylation followed by reduction of the thus‐obtained amides, as key‐reactions, or azides as key‐intermediates, for the assembly of the polyamine skeleton. Syntheses performed in solution as well as in the solid phase are discussed.

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Efficient and Flexible Solid‐Phase Synthesis of N‐Hydroxypolyamine Derivatives

Méret

Bienz

2008

Eur J Org Chem

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Orthogonally protected, N‐hydroxylated, linear tri‐ and tetra‐amines were efficiently synthesised on Merrifield resin, which was modified with a phenethyl bromide linker. The polyamine frameworks were convergently prepared “from the centre” with reductive aminations and nucleophilic substitutions to elongate the polyamine backbone. The required N‐hydroxy groups were introduced during the cleavage of the polyamine derivatives from the resin through Cope elimination.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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Role of polyamines in the binding of initiator tRNA to the 70S ribosomes of extreme thermophilic bacterium Calderobacterium hydrogenophilum

Cited by 8 publications

References 20 publications

Insights into thermoadaptation and the evolution of mesophily from the bacterial phylum Thermotogae

Insights into thermoadaptation and the evolution of mesophily from the bacterial phylum Thermotogae

Structure, Biological Activity and Synthesis of Polyamine Analogues and Conjugates

Efficient and Flexible Solid‐Phase Synthesis of N‐Hydroxypolyamine Derivatives

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