2005
DOI: 10.1016/j.cap.2005.01.012
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Role of polymeric stabilizers for drug nanocrystal dispersions

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Cited by 154 publications
(93 citation statements)
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“…39 Another possible factor is PVP K25's viscosity-imparting property, where an increase in the aqueous phase viscosity decreases the impact of shear stress applied to the system; this may decrease the extent of size reduction. 40 The values of ZP ranged from -22.1±3.65 to -37.1±4.41, which may be related to the intrinsic charge due to the ionization of DCN at pH of the dispersion medium (pH =4.88, whereas the pK a of DCN is 2.98).…”
Section: Measurement Of Ps Pdi and Zpmentioning
confidence: 99%
“…39 Another possible factor is PVP K25's viscosity-imparting property, where an increase in the aqueous phase viscosity decreases the impact of shear stress applied to the system; this may decrease the extent of size reduction. 40 The values of ZP ranged from -22.1±3.65 to -37.1±4.41, which may be related to the intrinsic charge due to the ionization of DCN at pH of the dispersion medium (pH =4.88, whereas the pK a of DCN is 2.98).…”
Section: Measurement Of Ps Pdi and Zpmentioning
confidence: 99%
“…The observed results were contrary to that mentioned by Verma et al 40 who related the steric hindrance capability to the geometrical differences between HPMC and polyvinyl pyrrolidone without considering the viscosity influence. Moreover, surface energy of both the drug and stabilizer measured by contact angle measurement plays an important role in the selection of a suitable and efficient NS stabilizer as reported by Choi et al 41 Hence, the formulation containing 0.2% w/v PVA was thereby used for further investigations having the smallest particle size (262.4±2.475 nm) with the lowest PdI (0.326±0.009).…”
mentioning
confidence: 99%
“…The nanocommunition is indeed a complex process involving several intertwined mechanisms Choi et al 2005). During this process, several mechanisms occur concurrently and in close connection.…”
Section: Discussionmentioning
confidence: 99%