Role of Polymorphic Variants of MTR Gene A2756G and SHMT1 Gene C1420T in the Development of Prostatic Cancer in Residents of the Western Siberian Region of Russia

Weiner, Alexandra S.; Oskina, N. А.; Lacarev, A. F.; Петрова, В. Д.; Ганов, Д И; Boyarskih, U. A.; Tonacheva, O. G.; Воронина, Е. Н.; Филипенко, М. Л.

doi:10.1007/s10517-012-1554-6

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…Rs1805087, one of the valuable SNPs in relation to PCa risk, may increase METH expression and indirectly participate in DNA methylation and the folate metabolic pathway. Subsequently, several investigators have confirmed these findings in larger samples and different populations [ 18 , 23 , 25 ]. Nonetheless, the lack of systematic and cohesive analysis renders these results ambiguous, even within the same population.…”

Section: Discussionmentioning

confidence: 70%

A single-nucleotide polymorphism (rs1805087) in the methionine synthase (METH) gene increases the risk of prostate cancer

Zhang

Tang

Shen

2018

Aging

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Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. The association between METH gene polymorphisms and prostate cancer susceptibility remains ambiguous. Thus, we performed an updated meta-analysis of METH single-nucleotide polymorphism rs1805087 involving 12 independent case-control studies comprising 9986 prostate cancer patients and 40134 controls. The odds ratio and 95% confidence intervals were applied to evaluate the relation of this single-nucleotide polymorphism with prostate cancer. Statistical analysis was performed in STATA 11.0. A significant association was found between rs1805087 and increased prostate cancer risk, overall and with Hardy–Weinberg equilibrium. In subgroup analyses (based on ethnicity, source of control, genotyping methods, or publication status), similar associations were observed (e.g., genotype GA vs. AA: odds ratio 1.19, 95% confidence interval 1.01–1.40 among whites; G allele vs. A allele: odds ratio 1.14, 95% confidence interval 1.02–1.28 among hospital-based controls). Thus, the common polymorphism (rs1805087) of METH may be associated with increased prostate cancer risk. Further studies with a larger sample size and detailed gene–environment interactions should be conducted to identify the role of METH polymorphisms in prostate cancer susceptibility.

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Section: Discussionmentioning

confidence: 70%

A single-nucleotide polymorphism (rs1805087) in the methionine synthase (METH) gene increases the risk of prostate cancer

Zhang

Tang

Shen

2018

Aging

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“…A meta-analysis conducted 10 years ago revealed no significant associations between Methionine synthase rs1805087 A/G variant and PCa risk 18 . From then on, more and more researchers ascertained their results in different populations 19,20,22,23,25,26 . Hence, in our systemic analysis, all eligible studies based on the inclusion criteria were summerized to ascertain a precise conclusion on the association between Methionine synthase rs1805087 A/G variant and PCa risk.…”

Section: Discussionmentioning

confidence: 99%

Update analysis on the association between Methionine synthase rs1805087 A/G variant and risk of prostate cancer

Zhang

et al. 2020

Sci Rep

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Previous studies have investigated the association of the rs1805087 A/G variant of Methionine synthase gene with the susceptibility to prostate cancer (PCa). Nevertheless, the conclusions remain divergent. We performed a systemic analysis with odds ratios (ORs) and 95% confidence intervals (95% CIs) to assess Methionine synthase rs1805087 A/G variant and PCa risk. Furthermore, we utilized in silico analysis to investigate the relationship between Methionine synthase expression and the overall survival (OS) time. Totally, 10,666 PCa patients and 40,750 controls were included. We observed that Methionine synthase rs1805087 A/G variant is associated with an elevated risk of PCa (G-allele vs. A-allele: OR = 1.06, 95% CI = 1.01-1.11, P = 0.013; heterozygous model: OR = 1.08, 95% CI = 1.02-1.14, P = 0.009; dominant model: OR = 1.08, 95% CI = 1.02-1.14, P = 0.007). During stratified analysis, similar results were obtained in Asian populations, hospital-based, high quality studies and that with large sample size. Moreover, in silico analysis indicated the Methionine synthase expression is down-regulated in both young and old PCa subjects (P < 0.05). Compared with the normal subjects, the down-regulated expression of Methionine synthase was found in PCa cases with Gleason score 6 to 9. Our study showed that Methionine synthase rs1805087 A/G variant may be associated with susceptibility of PCa, especially in Asian populations, hospital-based studies and that with high quality and large sample size. Furthermore, Methionine synthase rs1805087 A/G variant may be related to the prognosis of PCa.

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“…Three articles were excluded because of a lack of usable data. Eventually, a total of 23 eligible studies involving 14,409 cases and 16,996 controls were included in the pooled analyses (Chen et al, 2004;Zhang et al, 2005;Koushik et al, 2006;Hazra et al, 2007;Lissowska et al, 2007;Moore et al, 2007;van den Donk et al, 2007;Wang et al, 2007;Xu et al, 2007;Yu et al, 2007;Guerreiro et al, 2008;Steck et al, 2008;Stevens et al, 2008;Bentley et al, 2010;Komlosi et al, 2010;Vainer et al, 2010;Curtin et al, 2011;Mohammad et al, 2011;Naushad et al, 2011Naushad et al, , 2012Weiner et al, 2012;Succi et al, 2014;Wu et al, 2014). The characteristics of the studies selected are summarized in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis

Zhao¹,

Song²,

Zhang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A comprehensive search was conducted to identify all eligible studies of the SHMT1 rs1979277 polymorphism and solid tumor risk. The pooled odds ratios (ORs) and the 95% confidence intervals (95%CIs) were calculated using a fixed-or random-effects model. Heterogeneity was represented by P H ; publication bias and sensitivity analysis were also explored. Overall, no significant associations were found for any genetic models tested. However, upon stratification by cancer type, a significant decreased risk of breast cancer risk was identified in the homozygote comparison (OR = 0.79, 95%CI = 0.65-0.97 for TT versus CC). An analysis stratified (2015) by ethnicity and source of controls revealed an obvious decrease in risk among Asian groups in all genetic models, and among populationbased controls only in the homozygote comparison and recessive model. Therefore, our meta-analysis suggested that the SHMT1 C1420T polymorphism was associated with decreased risk of breast cancer. Significant protective effects were found among Asian populations, but not in Caucasian groups. Due to some minor limitations, our findings should be confirmed by further studies.

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Role of Polymorphic Variants of MTR Gene A2756G and SHMT1 Gene C1420T in the Development of Prostatic Cancer in Residents of the Western Siberian Region of Russia

Cited by 8 publications

References 12 publications

A single-nucleotide polymorphism (rs1805087) in the methionine synthase (METH) gene increases the risk of prostate cancer

A single-nucleotide polymorphism (rs1805087) in the methionine synthase (METH) gene increases the risk of prostate cancer

Update analysis on the association between Methionine synthase rs1805087 A/G variant and risk of prostate cancer

Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis

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