Role of polymorphism (rs1024611) in monocyte chemoattractant protein-1 gene in diabetic foot ulcer of Iraqi patients

Obied, Mariam Riyadh; Al-Tu’ma, Fadhil Jawad; Al-Jameel, Hameed Hussein

doi:10.1016/j.genrep.2019.100502

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Different results were shown in the study of Hamed et al in 2019. In Hamed's study, there was no significant difference in the number of blast cells in the TET2 gene polymorphism [9]. In the last two decades, advances in gene sequencing have been able to document gene sequence variations between individuals, implying that phenotypic diversity is formed by 0.5% of epigenetic modifications.…”

Section: Discussionmentioning

confidence: 94%

Effects of the FOXO3a rs 4946936 Gene Polymorphism on the FOXO3a Transcription Factor in Chronic Granulocytic Leukemia Patients

Wardhani

Susianti²,

Rahayu³

et al. 2021

Open Access Maced J Med Sci

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Introduction : FOXO3a has an important role in the maintenance of leukemic stem cells. BCR-ABL inhibition therapy by TKI dasatinib aims to reduce the phosphorylation of the transcription factor FOXO3a, promote localization of FOXO3a in the nucleus and restore transcriptional activity. However, some studies showed that the TKI dasatinib, in addition to increase the relocation of Foxo3a to the intranuclear, also increase the expression of CDKN1c/p57 and Bcl6 genes that became the down target for Foxo3a intra nucleus ATM. Therefore, current therapy is mostly directed at personalized therapy (personalized medicine). The aim of this study was to investigate the effect of the FOXO3a rs4946936 gene polymorphism on the Foxo3a transcription factor in chronic granulocytic leukemia patients treated with Imatinib mesylate. Method : This is a cross-sectional study in patients with chronic granulocytic leukemia (CGL) with positive Bcr-ABL. The aim was to prove the effect of the FOXO3a gene polymorphism rs4946936 on the Foxo3a transcription factor. The data analysis test used was a correlation test and a regression test. Result : There were three polymorphisms of the FOXO3a gene, namely CC polymorphism, TC polymorphism, and TT polymorphism with a p-value of 0.026 and an r of 0.287, so it can be concluded that there was a significant correlation between the FOXO3a gene polymorphism and the Foxo3an transcription factor with a sufficient correlation value. In the regression test between the FOXO3a gene polymorphisms and the transcription factor FOXO3a, the p value was 0.029 and the B value was -0.294. This means that it has a negative and significant effect on the Foxo3a transcription factor variable. Conclusion : There was a significant correlation between the gene polymorphism FOXO3a rs4946936 and the transcription factor FOX3a. The FOXO3a gene polymorphism of the TT genotype had a negative effect on the FOXO3a transcription factor. The TT gene in the FOXO3a gene polymorphism was the most effective in reducing the FOXO3a transcription factor.

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Section: Discussionmentioning

confidence: 94%

Effects of the FOXO3a rs 4946936 Gene Polymorphism on the FOXO3a Transcription Factor in Chronic Granulocytic Leukemia Patients

Wardhani

Susianti²,

Rahayu³

et al. 2021

Open Access Maced J Med Sci

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“…SIRT1 SNPs have been linked to the development of neural or vascular diseases [14], [15]. Monocyte chemoattractant protein-1 (MCP-1) is a pro-inflammatory cytokine that plays an important part in the inflammatory process, and the MCP-1 polymorphism rs1024611 was significantly correlated with increased DFU susceptibility [16]. SNPs in the vitamin D receptor (VDR) are implicated in the etiology of many inflammatory diseases [17]- [19].…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism and the risk of diabetic foot: a bibliometric analysis from 2011-2021

Maliza,

Irham,

Pradika

et al. 2023

IJPHS

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Diabetic foot ulcer (DFU) has been associated with genetic and environmental factors, which could potentially have a role in DFU development. Single nucleotide polymorphisms (SNPs) in genes linked to DFU, including inflammation. Bibliometric studies on the SNP on genes affecting DFU still have not been evaluated. This study aims to depict bibliographically and understand the topic trend of genetic polymorphism and the risk of DFU publications. A bibliometric methodology was applied in this study. The data were extracted through the Scopus database from 2011 to 2021. VOS viewer was used to classify and summarize Scopus articles. The 35 articles were evaluated. India topped the list of countries with the most publications, and Tehran University of Medical Sciences was the primary institution. Singh K and his team were the first contributing authors with 44 citations. Keywords analysis indicated that the research hotspots were DFU, type 2 diabetes mellitus (T2DM), diabetic foot ulcers, polymorphisms, hypoxia, vascular endothelial growth factor (VEGF), diabetic foot, diabetes mellitus, and oxidative stress. This study summarizes the current state, trends in genetic polymorphism and risk with DFU research. It may provide researchers with insight into the genetic polymorphism and risk associated with DFU research, as well as useful information for identifying possible collaborators and partner institutions.

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Genetic screening for pathogenic variants in type 2 diabetes of the Arab Gulf population: A systematic review and meta-analysis

Musafer,

Rava,

Al-Shuhaib

2023

Int J Diabetes Dev Ctries

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Role of polymorphism (rs1024611) in monocyte chemoattractant protein-1 gene in diabetic foot ulcer of Iraqi patients

Cited by 5 publications

References 21 publications

Effects of the FOXO3a rs 4946936 Gene Polymorphism on the FOXO3a Transcription Factor in Chronic Granulocytic Leukemia Patients

Effects of the FOXO3a rs 4946936 Gene Polymorphism on the FOXO3a Transcription Factor in Chronic Granulocytic Leukemia Patients

Genetic polymorphism and the risk of diabetic foot: a bibliometric analysis from 2011-2021

Genetic screening for pathogenic variants in type 2 diabetes of the Arab Gulf population: A systematic review and meta-analysis

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