Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Shahwan, Moyad; Alhumaydhi, Fahad A.; Ashraf, Ghulam Md; Hasan, P.M.Z.; Shamsi, Anas

doi:10.1016/j.ijbiomac.2022.03.004

Cited by 131 publications

(80 citation statements)

References 180 publications

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“…Polyphenols such as flavonoids and tannins can inhibit the digestion of carbohydrates to glucose by inhibiting the activity of key enzymes, such as α-glucosidase and α-amylase [ 46 ]. According to the literature, some of the flavonoids detected by HPLC-MS in our study have been reported to have potential hypoglycemic and antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

“…It is worth noting that the α-glucosidase inhibitory abilities of delphinidin 3- O - β -D-galactoside, 3,5,7,2′,6′-pentahydroxyflavone, 5,7,2′,3′-tetrahydroxyflavone, 3′-methoxydaidzein, and delphinidin 3′- O -(2″- O -galloyl- β -galactoside) peonidin via molecular docking were reported for the first time, as shown in Table 3 . Furthermore, several polyphenols, such as resveratrol, epigallocatechin-3-gallate and quercetin, enhanced glucose uptake in the muscles and adipocytes by translocating GLUT4 to plasma membrane mainly by the activation of the AMP-activated protein kinase pathway [ 46 ]. In summary, it could be seen that the in vitro hypoglycemic activity of PAH might be related to the inhibition of α -glucosidase (EAF, PEF, and NBF) and the promotion of glucose uptake in 3T3-L1 adipocytes (NBF).…”

Section: Discussionmentioning

confidence: 99%

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Hypoglycemic and Antioxidant Properties of Extracts and Fractions from Polygoni Avicularis Herba

et al. 2022

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Our research focused on the hypoglycemic capability and the possible mechanisms of extract and fractions from Polygoni Avicularis Herba (PAH) based on α-glucosidase, α-amylase inhibition assays, glucose uptake experiment, HPLC-MS analysis, and molecular docking experiment. In addition, DPPH, ABTS, and FRAP assays were used for determining the antioxidant capability. The results of total flavonoids and phenolics contents showed that ethyl acetate fraction (EAF) possessed the highest flavonoids and phenolics with values of 159.7 ± 2.5 mg rutin equivalents/g and 107.6 ± 2.0 mg galic acid equivalents/g, respectively. The results of in vitro hypoglycemic activity showed that all samples had effective α-glucosidase inhibition capacities, and EAF possessed the best inhibitory effect with IC50 value of 1.58 ± 0.24 μg/mL. In addition, n-butanol fraction (NBF) significantly promoted the glucose uptake rate of 3T3-L1 adipocytes. HPLC-MS analysis and molecular docking results proved the interactions between candidates and α-glucosidase. The results of antioxidation capacities showed that EAF possessed the best antioxidation abilities with DPPH, ABTS, and FRAP. In summary, the hypoglycemic activity of PAH might be related to the inhibition of α-glucosidase (EAF > PEF > NBF) and the promotion of glucose uptake in 3T3-L1 adipocytes (NBF). Simultaneously, the antioxidation capacity of PAH might be related to the abundant contents of flavonoids and other phenolics (EAF > PEF > NBF).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hypoglycemic and Antioxidant Properties of Extracts and Fractions from Polygoni Avicularis Herba

et al. 2022

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“…The kidney is the most important target of microvascular damage in diabetes. Many flavonoids are reported to improve hyperglycemia and increase insulin sensitivity in in vitro and in vivo studies [ 69 , 70 ].…”

Section: Bioactivities Of Flavonoids In Ckdmentioning

confidence: 99%

Flavonoids in Treatment of Chronic Kidney Disease

et al. 2022

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Chronic kidney disease (CKD) is a progressive systemic disease, which changes the function and structure of the kidneys irreversibly over months or years. The final common pathological manifestation of chronic kidney disease is renal fibrosis and is characterized by glomerulosclerosis, tubular atrophy, and interstitial fibrosis. In recent years, numerous studies have reported the therapeutic benefits of natural products against modern diseases. Substantial attention has been focused on the biological role of polyphenols, in particular flavonoids, presenting broadly in plants and diets, referring to thousands of plant compounds with a common basic structure. Evidence-based pharmacological data have shown that flavonoids play an important role in preventing and managing CKD and renal fibrosis. These compounds can prevent renal dysfunction and improve renal function by blocking or suppressing deleterious pathways such as oxidative stress and inflammation. In this review, we summarize the function and beneficial properties of common flavonoids for the treatment of CKD and the relative risk factors of CKD.

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“…There are four major classes of polyphenols including phenolic acids, flavonoids, stilbenes, and lignans ( Figure 3 ) [ 100 ]. Polyphenols have ignited a lot of interest in the scientific community because of their health benefits, especially for metabolic disorders like DM [ 101 ]. Since DM is a multifactorial disease, finding alternative therapy that can target many mechanisms is critical.…”

Section: Polyphenolmentioning

confidence: 99%

The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders

Nor

Budin

Zainalabidin

et al. 2022

IJMS

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Diabetes-induced vascular disorder is considered one of the deadly risk factors among diabetic patients that are caused by persistent hyperglycemia that eventually leads to cardiovascular diseases. Elevated reactive oxygen species (ROS) due to high blood glucose levels activate signaling pathways such as AGE/RAGE, PKC, polyol, and hexosamine pathways. The activated signaling pathway triggers oxidative stress, inflammation, and apoptosis which later lead to vascular dysfunction induced by diabetes. Polyphenol is a bioactive compound that can be found abundantly in plants such as vegetables, fruits, whole grains, and nuts. This compound exerts therapeutic effects in alleviating diabetes-induced vascular disorder, mainly due to its potential as an anti-oxidative, anti-inflammatory, and anti-apoptotic agent. In this review, we sought to summarize the recent discovery of polyphenol treatments in modulating associated genes involved in the progression of diabetes-induced vascular disorder.

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Role of polyphenols in combating Type 2 Diabetes and insulin resistance

Cited by 131 publications

References 180 publications

Hypoglycemic and Antioxidant Properties of Extracts and Fractions from Polygoni Avicularis Herba

Hypoglycemic and Antioxidant Properties of Extracts and Fractions from Polygoni Avicularis Herba

Flavonoids in Treatment of Chronic Kidney Disease

The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders

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