Role of Pomegranate in the Management of Cancer

Abstract

Pomegranate (Punica granatum) has been used since ages as a folk medicine. Studies have shown that pomegranate extracts have a role in various signaling pathways involved in inflammation, cellular transformation, hyperproliferation, angiogenesis, initiation of tumorigenesis, and eventually suppressing the final steps of tumorigenesis and metastasis. In this chapter, we have discussed some of the polyphenolic constituents present in pomegranate and their medical value, and we then discussed studies on chemopreventive/chemotherapeutic properties of pomegranate against various types of cancer, such as skin, prostate, colon, head and neck and lung cancers in cell culture systems, animal models and humans.

Dietary supplementation of pomegranate extract alters the Caspase-3 and VEGF promoter epigenetic methylation status and protein levels in breast cancer patients undergoing chemotherapy

“…Because it contains a significant number of hydrolyzable tannins and anthocyanins, pomegranate possesses potent antioxidant and anti-inflammatory properties (Singh et al, 2023). Several studies have demonstrated that the pomegranate extract (PE), seeds, and juice exerts anti-cancer potential by altering several key signaling pathways controlling cell division and proliferation (Malik et al, 2005;Adhami et al, 2009;Turrini et al, 2015;Amulya et al, 2021).…”