Role of positron emission tomography computed tomography in carcinoma lung evaluation

Abstract

Lung cancer has graduated from merely a reportable disease of 1912 to being the most common cause of cancer death in developed countries in recent years. The annual number of lung cancer deaths is greater than the combined cancer deaths from breast, colon and prostate. Its association with tobacco has been proved and is related to the type, amount of tobacco used, the age at initiation and duration of use. Significant advances have been made in the diagnosis and management of lung cancer over the past decade. The primary treatment of lung cancer is surgery and the best chance for a complete cure comes from the total resection of localized disease. Once nodal or distant metastases have developed, primary surgical intervention is ruled out and patient is considered for adjuvant chemotherapy with or without radiation therapy. Accurate staging and delineation of disease extent is therefore critical in the treatment planning of lung carcinoma patients. 18 F fluoro deoxy glucose (FDG) positron emission tomography (PET) has been proven to be a valuable noninvasive imaging modality in the evaluation of patients with known or suspected lung cancer and its integration with computed tomography (CT) has changed the face of PET imaging in many ways. This article will review the current role of FDG PET CT in the evaluation of pulmonary nodules, diagnosis, staging and restaging of non-small-cell lung carcinoma (NSCLC), role of PET in small cell lung Carcinoma (Ca), pleural disease and will also discuss its potential future applications.

Preoperative 18F-Fluorodeoxyglucose Positron Emission Tomography can Predict the Tumor Malignancy of Small Peripheral Lung Cancer

“…The most widely used SUV max cutoff value for benign and malignant lung nodules is 2.5. 7,8) The purpose of the present study was to examine the correlation between the SUV max of peripheral small lung cancers (≤2 cm in size) and various clinicopathological features related to tumor invasiveness, nodal metastasis, and recurrence to evaluate the utility of FDG-PET for the evaluation of tumor malignancy grading.…”

The Impact of Pleural Lavage Cytology Before and After Resection on Prognosis

“…Imaging methods prove the most important non-invasive method in lung cancer staging. PET-CT is valued as better compared to CT and MR in N staging which one of the main parameters in staging [13,14]. PET/CT is used for initial staging of the tumor, to evaluate response to treatment, to detect residual and recurrent disease after the treatment in lung malignancies [15].…”

“…Besides, SUVmax value of mass had positive correla- tion with pathological stage, tumor diameter and gender. TNM staging is one of the most important methods in identifying prognosis in lung cancer [12][13][14][15][16][17][18][19]. Certain clinical factors impact on prognosis regardless of the cancer stage.…”

Akciğer Kanserinde Evreleme: Yenilikler

“…'ları [28] tarafından yapılan bir çalışmada N evrelemesinde Pozitron Emisyon Tomografi-Bilgisayarlı Tomografi (PET-BT)'nin BT'ye üstün olduğu gösterilmiştir. Bu çalışmada normal boyuttaki (kısa aksı <1cm ) lenf bezleri için PET-BT'nin duyarlılığı %74 ve özgüllüğü %96 bulunmuştur.…”