Role of posterior hypothalamus in hypobaric hypoxia induced pulmonary edema

Sharma, Ramesh; Choudhary, Rishabh; Reddy, Maram K.; Ray, Arunabha; Ravindran, Krishnan

doi:10.1016/j.resp.2014.10.010

Cited by 8 publications

(5 citation statements)

References 69 publications

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“…5, A-C), a typical characteristic of TH-ir neurons in this region (35,36) with TH-ir also present in the nuclei, similar to a previous description in ventral tegmental area neurons (37). Neurons in the PH have been implicated in pulmonary hypertension (38) and in arousal (39), but the physiological and/or thermoregulatory role of the PH input to the rRPa, including the DA neurons, remains to be identified. DA neurons in the substantia nigra express transient receptor potential vanilloid-type 3 (TRPV3) and type 4 (TRPV4), respectively, and their discharge is sensitive to local temperature (40).…”

Section: Discussionsupporting

confidence: 80%

Dopaminergic input from the posterior hypothalamus to the raphe pallidus area inhibits brown adipose tissue thermogenesis

Furber

Mota

Veytsman

et al. 2021

American Journal of Physiology-Regulatory, Integrative and Comp

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Systemic administration of dopamine (DA) receptor agonists leads to falls in body temperature. However, the central thermoregulatory pathways modulated by DA have not been fully elucidated. Here we identified a source and site of action contributing to DA's hypothermic action by inhibition of brown adipose tissue (BAT) thermogenesis. Nanoinjection of the type 2 and type 3 DA receptor (D2R/D3R) agonist, 7-OH-DPAT, in the rostral raphe pallidus area (rRPa) inhibits the sympathetic activation of BAT evoked by cold exposure or by direct activation of NMDA receptors in the rRPa. Blockade of D2R/D3R in the rRPa with nanoinjection of SB-277011A increases BAT thermogenesis, consistent with a tonic release of DA in the rRPa contributing to inhibition of BAT thermogenesis. Accordingly, D2R are expressed in cold-activated and serotonergic neurons in the rRPa and anatomical tracing studies revealed that neurons in the posterior hypothalamus (PH) are a source of dopaminergic input to the rRPa. Disinhibitory activation of PH neurons with nanoinjection of gabazine inhibits BAT thermogenesis, which is reduced by pre-treatment of the rRPa with SB-277011A. In conclusion, the rRPa, the site of sympathetic premotor neurons for BAT, receives a tonically-active, dopaminergic input from the PH that suppresses BAT thermogenesis.

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Section: Discussionsupporting

confidence: 80%

Dopaminergic input from the posterior hypothalamus to the raphe pallidus area inhibits brown adipose tissue thermogenesis

Furber

Mota

Veytsman

et al. 2021

American Journal of Physiology-Regulatory, Integrative and Comp

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show abstract

“…These responses were significantly attenuated after lesioning posterior hypothalamus or after chronic infusion of GABA receptor agonist muscimol into posterior hypothalamus. Interestingly, chronic infusion of the NO donor SNAP into the posterior hypothalamus mitigated such attenuation (Sharma et al, 2015). Together during hypobaric hypoxia over-activity of posterior hypothalamic neurons via local decrease in GABA-ergic inhibition increased the sympathetic drive and thus pulmonary hypertension and edema.…”

Section: Studies On Central Nervous System and Related Pathological Cmentioning

confidence: 99%

“…Together suggests that estrogen and its interactions with oxidative stress including NO are central to gender based differences in cold restraint stress induced gastric ulceration (Gulati et al, 2015). In a study, hypobaric hypoxia using high altitude simulation chamber (294.4 mmHg) for 24 h resulted in elevation of arterial blood pressure, renal sympathetic nerve activity, right ventricular systolic pressure, lung wet to dry weight ratio and Evans blue dye leakage (Sharma et al, 2015). These responses were significantly attenuated after lesioning posterior hypothalamus or after chronic infusion of GABA receptor agonist muscimol into posterior hypothalamus.…”

Section: Studies On Central Nervous System and Related Pathological Cmentioning

confidence: 99%

Recent Advancement in Nitric Oxide Research in India

Gaikwad¹,

Kumar²,

Dikshit³

2018

Proceedings of the Indian National Science Academy

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Discovery of nitric oxide (NO), as endothelial derived relaxing factor that has been awarded with Nobel Prize, highlights its importance as master signalling molecule in diverse systems. Recent research has unfolded several unknown facets of this intriguing biomolecule in cardiovascular system, immunomodulation neurotransmission and plant physiology. NO produced by nitric oxide synthases (NOSs), is a short lived radical that reacts with superoxide radicals to generate reactive nitrogen species and potent oxidant, peroxynitrite implying damage in various pathological conditions. This adds another level of complexity in the understanding of pathological conditions associated with NO paucity or due to increased reactive oxygen nitrogen species (RONS). Researchers from India have been instrumental in unfolding various important and novel functions of this molecule and associated signalling by using multipronged approaches in different systems. Association of NO signaling with increased burden of life style diseases in recent years provide sufficient rationale to investigate NO in diverse pathophysiological conditions in Indian perspective. Here we review recent and important contributions of Indian science during last five years in understanding of NO signaling fundamentals in human, animals and also plants, its association with diverse pathological conditions and therapeutic targeting with possible ameliorative strategies.

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“…Of these, HVR and the sympathetic nervous system response are clearly related to the brain and central nervous system with contributions by the hypothalamus where cardio-respiratory control centers exist. To assess the contribution of the hypothalamus in HAPE, Sharma et al (2015) studied rats in which it was possible to injury the posterior hypothalamus with electrical energy applied by stereotactically placed microelectrodes. After recovery, treated and sham-treated animals were then exposed to either normobaria or hypobaric hypoxia (Pb = 294 mmHg, equivalent to 7315 m) for 24 hours.…”

Section: Role Of the Brain In High Altitude Pulmonary Edema (Hape)mentioning

confidence: 99%

Sightings edited by Erik Swenson and Peter Bärtsch

2015

High Altitude Medicine & Biology

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Role of posterior hypothalamus in hypobaric hypoxia induced pulmonary edema

Cited by 8 publications

References 69 publications

Dopaminergic input from the posterior hypothalamus to the raphe pallidus area inhibits brown adipose tissue thermogenesis

Dopaminergic input from the posterior hypothalamus to the raphe pallidus area inhibits brown adipose tissue thermogenesis

Recent Advancement in Nitric Oxide Research in India

Sightings edited by Erik Swenson and Peter Bärtsch

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