Role of postoperative radiotherapy in dermatofibrosarcoma protuberans: a propensity score-matched analysis

Du, Kaifan; Li, Jinluan; Tang, Lian; Lin, Xiaojuan; Kong, Xiangquan; Liao, Xuehong; Peng, Qingqin; Dong, Yi; He, Jinlan; Huang, Yao Qi; Zhang, Xueqing; Lin, Feifei; Zhuang, Q.

doi:10.1186/s13014-019-1226-z

Cited by 20 publications

(18 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The treatment, for DFSP of the breast, is based on surgery, whether primary or recurrent. The principal aim of surgery is to remove the tumor completely, because of the close relationship between residual tumor and local recurrence [ 41 – 43 ]. WLE is a very reasonable approach that has been widely used worldwide for DFSP of the breast.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

Wang

Chen

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade fibroblastic mesenchymal tumor derived from the dermis. The aim of this retrospective analysis was to summarize the clinicopathological data from our cases and published cases to offer more evidence for the recognition of dermatofibrosarcoma protuberans (DFSP). A total of 6 breast DFSP patients who had received treatment in our hospital were retrospectively enrolled, and detailed clinicopathological data were gathered for analysis. The median age was 29.5 years (ranging from 17 to 42 years). Most cases presented a red or brown-red, mobile, well-circumscribed, protruding, breast mass (ranging from 1 to 3 cm). For histopathology, all cases (6/6) showed a storiform pattern of spindle cells that were positive for CD34 (6/6) and Vimentin (5/6) and negative for smooth muscle actin (0/6) and S-100 protein (0/6). The majority of patients (5/6) underwent wide local excision, with 2 cases treated with radiotherapy. With a median follow-up of 36 months, all 6 patients survived without recurrence or metastasis. The PubMed database was used to search for similar cases. Eventually, 36 cases were included in this review, while cases without detailed clinical information or not reported in English were excluded from the analysis. To summarize, DFSP of the breast is an extremely rare malignancy characterized by spindle tumor cells arranged in a storiform pattern and positivity for CD34. The core needle biopsy is one of the crucial methods for its preoperative diagnosis. Management of DFSP is mainly based on surgical excision. It is prone to local recurrence, so long-term follow-up is required.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Multiple studies have shown that DFSP is a radioresponsive tumor [ 41 , 49 ]. For recurrent tumors or unresectable residual lesions, adjuvant radiotherapy is recommended in order to control the progression of disease [ 32 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

Wang

Chen

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Patients with local recurrences were managed with repeated surgery with wide resection margins. Whenever anatomic or cosmetic difficulties to achieve adequate margins existed, postoperative RT [8] was given in an effort to improve local control and prevent unfavorable functional or cosmetic outcomes. Expectedly, distant recurrences were uncommon in our patients [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

“…Agarwal et al [12] have shown that dermatofibromas have a higher proliferation index when compared to the superficial/peripheral portion of DFSP. Using 17% as the optimal cut-off point, Du et al [8] reported that patients with high Ki-67 expression had less favorable 5-year disease-free survival compared to those with expression levels. Our study is the first to analyze the Ki-67 index with respect to RFS as the outcome of interest.…”

Section: Discussionmentioning

confidence: 99%

The Ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans

Adem

Yazıcı

Özşen

et al. 2020

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma that originates from the dermis or subcutaneous tissue in the skin. While its prognosis is generally favorable, disease recurrence is relatively frequent. Because morbidity after repeated surgery may be significant, an optimized prediction of recurrence-free survival (RFS) has the potential to improve current management strategies. The purpose of this study was to investigate the prognostic value of the Ki-67 proliferation index with respect to RFS in patients with DFSP. We retrospectively analyzed data from 45 patients with DFSP. We calculated the Ki-67 proliferation index as the percentage of immunostained nuclei among the total number of tumor cell nuclei regardless of the intensity of immunostaining. We constructed univariate and multivariate Cox proportional hazards regression models to identify predictors of RFS. Among the 45 patients included in the study, 8 developed local recurrences and 2 had lung metastases (median follow-up: 95.0 months; range: 5.2−412.4 months). The RFS rates at 60, 120, and 240 months of follow-up were 83.8%, 76.2%, and 65.3%, respectively. The median Ki-67 proliferation index was 14%. Notably, we identified the Ki-67 proliferation index as the only independent predictor for RFS in multivariate Cox proportional hazards regression analysis (hazard ratio = 1.106, 95% confidence interval = 1.019−1.200, p = 0.016). In summary, our results highlight the potential usefulness of the Ki-67 proliferation index for facilitating the identification of patients with DFSP at higher risk of developing disease recurrences.

show abstract

“…A fibrosarcoma is a low-grade malignant tumor with a local recurrence rate of 60%[1]. The incidence of distant metastases is <1%[2,3].…”

Section: Introductionmentioning

confidence: 99%

Dermatofibrosarcoma metastases to the pancreas: A case report

Cai

Fang

Cao

et al. 2019

WJCC

View full text Add to dashboard Cite

BACKGROUNDIn general, malignant tumors metastasize to the pancreas in < 1% of cases. Most patients miss the opportunity for further surgery due to distant metastases; however, for fibrosarcomas, aggressive surgery may be helpful even if distant metastases occur. Hence, we report such a case and share some valuable information about the disease.CASE SUMMARYA 45-year-old man was admitted with recurrent epigastric pain for 10 days. The abdominal pain was mainly related to bloating with nausea, but no other associated symptoms. No particular signs were found on abdominal examination or laboratory testing. In 2003, a local distal expanded resection of the primary fibrosarcoma in the left chest wall was performed. Then, a left pneumonectomy was performed in 2017 due to diffuse metastases from the fibrosarcoma to the left lung. Enhanced computed tomography (CT) and magnetic resonance imaging of the upper abdomen suggested multiple masses of different sizes involving the head and tail of the pancreas; no local lymph node enlargement was noted. The postoperative pathologic diagnosis revealed a fibrosarcoma of the pancreas. A CT re-examination 6 mo postoperatively showed no local recurrence or distant metastases.CONCLUSIONA fibrosarcoma is a rare low-grade malignant tumor, and metastases to the pancreas are even rarer. Patients with a history of a fibrosarcoma should consider the possibility of metastasis when a pancreatic neoplasm is demonstrated. Surgical resection is the preferred treatment.

show abstract

Role of postoperative radiotherapy in dermatofibrosarcoma protuberans: a propensity score-matched analysis

Cited by 20 publications

References 25 publications

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

A Rare Malignant Disease, Dermatofibrosarcoma Protuberans of the Breast: A Retrospective Analysis and Review of Literature

The Ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans

Dermatofibrosarcoma metastases to the pancreas: A case report

Contact Info

Product

Resources

About