2024
DOI: 10.15407/fz70.02.035
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Role of Potassium Channel Trek-1 in Mechanosensitivity of Smooth Muscle Cells From Rat Detrusor

S.I. Yeliashov,
B.R. Sharopov,
Ya.M. Shuba

Abstract: Currently, TREK-1 is considered to be the main mechanosensitive channel in detrusor smooth muscle (DSM) cells. The aim of our study was to detect the functioning of the K+-conducting mechanosensitive TREK-1 channel in rat DSM cells using the patch-clamp technique in response to hydrodynamic stimulation (shear stress) and to determine the effects of a TREK-1 agonist – arachidonic acid (AA) and an antagonist – L-methionine. Mechanical stimulation of DSM cells using hydrodynamic stress led to the appearance of a … Show more

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