Role of potassium lateral diffusion in non-synaptic epilepsy: A computational study

Park, Eun Hyoung; Durand, Dominique M.

doi:10.1016/j.jtbi.2005.06.015

Cited by 55 publications

(84 citation statements)

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“…The hypothesis is that sustained, spontaneous neuronal activity can be generated by potassium lateral diffusion coupling between neurons. To test this hypothesis, the effect of potassium lateral diffusion on the synchronization and generation of neuronal activity was examined using modified Hodgkin -Huxley (HH) type model neurons and more physiologically relevant CA1 pyramidal neurons (Park & Durand 2006).…”

Section: Computer Simulation Of Lateral Diffusion In Neural Networkmentioning

confidence: 99%

“…Potassium pump dynamics (Tuckwell & Miura 1978;Bazhenov et al 2004) and a glial uptake mechanism (Kager et al 2000;Bazhenov et al 2004) were included in the model to remove the excess potassium ions from the interstitial space. Equations, variables, and parameters for each HH type cell can be found in Park & Durand (2006).…”

Section: Computer Simulation Of Lateral Diffusion In Neural Networkmentioning

confidence: 99%

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Potassium diffusive coupling in neural networks

Durand

Park

Jensen

2010

Phil. Trans. R. Soc. B

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Conventional neural networks are characterized by many neurons coupled together through synapses. The activity, synchronization, plasticity and excitability of the network are then controlled by its synaptic connectivity. Neurons are surrounded by an extracellular space whereby fluctuations in specific ionic concentration can modulate neuronal excitability. Extracellular concentrations of potassium ([K þ ] o ) can generate neuronal hyperexcitability. Yet, after many years of research, it is still unknown whether an elevation of potassium is the cause or the result of the generation, propagation and synchronization of epileptiform activity. An elevation of potassium in neural tissue can be characterized by dispersion (global elevation of potassium) and lateral diffusion (local spatial gradients). Both experimental and computational studies have shown that lateral diffusion is involved in the generation and the propagation of neural activity in diffusively coupled networks. Therefore, diffusion-based coupling by potassium can play an important role in neural networks and it is reviewed in four sections. Section 2 shows that potassium diffusion is responsible for the synchronization of activity across a mechanical cut in the tissue. A computer model of diffusive coupling shows that potassium diffusion can mediate communication between cells and generate abnormal and/or periodic activity in small ( §3) and in large networks of cells ( §4). Finally, in §5, a study of the role of extracellular potassium in the propagation of axonal signals shows that elevated potassium concentration can block the propagation of neural activity in axonal pathways. Taken together, these results indicate that potassium accumulation and diffusion can interfere with normal activity and generate abnormal activity in neural networks.

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Section: Computer Simulation Of Lateral Diffusion In Neural Networkmentioning

confidence: 99%

Section: Computer Simulation Of Lateral Diffusion In Neural Networkmentioning

confidence: 99%

Potassium diffusive coupling in neural networks

Durand

Park

Jensen

2010

Phil. Trans. R. Soc. B

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“…Previous studies have found that the K ? lateral diffusion between two neurons is a significant factor for non-synaptic epileptogenesis in a low-calcium in vitro model (Yaari et al 1986;Park and Durand 2006;Durand and Jensen 2010). Chemical synapses are abundant in the central nervous system.…”

Section: Elevated Bath K 1 Concentration Can Induce Epileptic Seizuresmentioning

confidence: 99%

“…concentration in the ECS-NA could induce epileptic seizures? A number of results from biological experiments have answered this question (Ohno et al 2015;Cornog et al 1967; Traynelis and Dingledine 1988;Durand and Jensen 2010;Park and Durand 2006). In 2015, Ohno found that down-regulation or dysfunction of K ?…”

Section: Introductionmentioning

confidence: 99%

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The influence of potassium concentration on epileptic seizures in a coupled neuronal model in the hippocampus

Wang

2016

Cogn Neurodyn

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Experiments on hippocampal slices have recorded that a novel pattern of epileptic seizures with alternating excitatory and inhibitory activities in the CA1 region can be induced by an elevated potassium ion (K ? ) concentration in the extracellular space between neurons and astrocytes (ECS-NA). To explore the intrinsic effects of the factors (such as glial K ? uptake, Na ? lateral diffusion leads to epileptic seizure in neurons only when the synaptic conductance values of the excitatory and inhibitory neurons are within an appropriate range. Finally, we propose an energy factor to measure the metabolic demand during neuron firing, and the results show that different energy demands for the normal discharges and the pathological epileptic seizures of the coupled neurons.

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