Role of Pre-procedural C-reactive Protein Level in the Prediction of Major Adverse Cardiac Events in Patients Undergoing Percutaneous Coronary Intervention: a Meta-analysisof Longitudinal Studies

Bibek, Singh-baniya; Xie, Yucheng; Gao, Jiajia; Wang, Zhi; Wang, Jingfeng; Geng, Deqin

doi:10.1007/s10753-014-0018-8

Cited by 22 publications

(19 citation statements)

References 59 publications

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“…In patients undergoing coronary angioplasty, it has been shown that high CRP levels were associated with early complications and late clinical outcomes [6,17]. A recently published meta-analysis suggests that preprocedural serum CRP level is a valuable predictor of MACEs in patients undergoing PCI [7]. Platelets are an important factor for the development of atherosclerotic lesions, plaque destabilization and atherothrombosis [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

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High-sensitivity C-reactive protein and mean platelet volume as predictive values after percutaneous coronary intervention for long-term clinical outcomes

Moon

Choi²,

Jahng³

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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This study was designed to establish the relationship of high-sensitivity C-reactive protein (hsCRP) and mean platelet volume (MPV) with the development of adverse outcomes after percutaneous coronary intervention (PCI). hsCRP levels and MPV were analysed in 372 patients who underwent PCI, with the primary endpoint as major adverse cardiac and cerebrovascular events (MACCE): a composite of cardiac death, myocardial infarction (MI), target vessel revascularization (TVR), ischemic stroke and stent thrombosis. During the follow-up period (mean, 25.8 months), there were 21 cardiac deaths, 10 MIs including four stent thrombosis events, seven ischemic strokes and 29 TVRs. The hsCRP cut-off level was set at 0.31 mg/dl using the receiver operating characteristic curve to differentiate between the groups with and without MACCE. The MPV cut-off level was set at 8.00 fl by the receiver operating characteristic curve to differentiate between the groups with and without MACCE. A Kaplan-Meier analysis revealed that the high hsCRP group (≥0.31 mg/dl) had a significantly higher cardiac death and MACCE rate than the low hsCRP group (<0.31 mg/dl), and the high MPV group (>8.00 fl) had a significantly higher cardiac death and MACCE rate than the low MPV group (≤8.00 fl). Furthermore, the high hsCRP and MPV groups were significantly associated with an increased risk of MACCE. These results show that hsCRP and MPV are predictive markers after PCI for MACCE; they are also additively associated with a higher risk of MACCE.

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Section: Discussionmentioning

confidence: 99%

“…In patients undergoing coronary angioplasty, it has been shown that high CRP levels are associated with early complications and late clinical restenosis [6]. A recently published meta-analysis suggests that the preprocedural serum CRP level is a valuable predictor of MACE in patients undergoing percutaneous coronary intervention (PCI) [7].…”

Section: Introductionmentioning

confidence: 99%

High-sensitivity C-reactive protein and mean platelet volume as predictive values after percutaneous coronary intervention for long-term clinical outcomes

Moon

Choi²,

Jahng³

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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“…1–9 In particular, an inflammatory protein, C-reactive protein (CRP), has been identified as a predictor of cardiovascular risk given its association with increased morbidity and poor outcomes among patients with vascular disease as well as its potential role in atherogenesis. 10–16 The Inflammatory Bowel Diseases (IBDs), including Crohn’s Disease (CD) and Ulcerative Colitis (UC) have been similarly associated with increased cardiovascular risks, including coronary artery disease (CAD) and thromboembolic events of the venous and arterial systems. 17–20 Patients with IBD often have long periods of remission with intermittent relapses of intestinal inflammation, and these increased cardiovascular risks have been documented during periods of both IBD flare and remission.…”

Section: Introductionmentioning

confidence: 99%

Hospitalizations for Acute Myocardial Infarction Are Decreased Among Patients with Inflammatory Bowel Disease Using a Nationwide Inpatient Database

Barnes

Beery

Schulman

et al. 2016

Inflammatory Bowel Diseases

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Background: Questions remain regarding the true prevalence of cardiovascular events such as myocardial infarction (MI) among patients with Inflammatory Bowel Disease (IBD). Using the Nationwide Inpatient Sample (NIS), we aimed to compare the proportion of hospitalizations for acute MI among patients with IBD to that of the general population. Methods: This study used data from years 2000–2011 in NIS, the largest publicly available all-payer inpatient database in the US. International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) discharge codes were used to identify adult patients with discharge diagnoses of IBD (Ulcerative Colitis or Crohn’s Disease), acute MI, and multiple comorbid risk factors for cardiovascular disease. The independent effect of a diagnosis of IBD on risk of acute MI was examined using a multivariable logistic regression model controlling for multiple confounders. Data were analyzed using SAS survey procedures and weighted to reflect national estimates. Results: We identified 567,438 hospitalizations among patients with IBD and 78,121,000 hospitalizations among the general population. Patients with IBD were less likely to be hospitalized for acute MI than patients in the general population (1.3% vs. 3.1%, p<0.001). In adjusted analyses, the odds of hospitalization for acute MI among patients with IBD were decreased when compared to the general population (OR 0.51, 95% CI 0.50 – 0.52). Conclusions: Despite prior reports of a potentially increased risk of acute MI among patients with IBD, in a nationwide inpatient database, lower rates of acute MI were demonstrated in the IBD population when compared to the general population.

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“…However, DESs are not immune to restenosis in the long run (6), and ISR is also common in DES generation (12% -23.5%) (6,11). In spite of heterogeneity across studies, evidence has indicated that plasma high-sensitivity C-reactive protein (hs-CRP) level, as an inflammatory biomarker, could predict coronary ISR after stenting at both admission and follow-up in patients (14)(15)(16). Interleukin-6 (IL-6), as an established inflammatory biomarker of atherosclerosis, could also predict coronary stenosis with high sensitivity and specificity (17,18).…”

Section: Introductionmentioning

confidence: 99%

Effects of Therapeutic Lifestyle Change Diet and Q10 Plus L-Carnitine Supplementation on Inflammatory Biomarkers of In-Stent Restenosis, Lipid Profile, and Left Ventricular Ejection Fraction in Myocardial Infarction: A Randomized Clinical Trial

Sharifi

Eftekhari

Ostovan

et al. 2017

Iran Red Crescent Med J

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Background: Following Myocardial Infarction (MI) and percutaneous coronary intervention (PCI), the modification of cardiovascular risk factors and inflammation can improve MI progression and PCI outcomes. Up to now, no certain conclusions have been drawn regarding the effect of therapeutic lifestyle change (TLC) diet and a combination of Q10 plus L-carnitine (LC) supplementation on inflammatory biomarkers of In-Stent Restenosis (ISR), lipid profile, and Left ventricular ejection fraction (LVEF).Objectives: This study aimed to evaluate the effects of TLC diet and Q10 plus LC supplementation on inflammatory biomarkers of ISR, lipid profile, and LVEF following MI and PCI.Methods: This single-blind randomized controlled trial was conducted on 128 subjects. After randomization for treatment allocation, the subjects were divided into the study groups through block randomization. The MI patients were admitted to 2 hospitals, namely Al-Zahra and Kowsar (Shiraz, Iran), between April 2015 and May 2016. The patients were divided into 4 groups receiving TLC diet (A), oral Q10 150 mg/d and LC 1200 mg/d (B), a combination of LC plus Q10 and TLC diet (C), and the routine care (D). This study evaluated Interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP) as inflammatory biomarkers of ISR, lipid profile, and LVEF in 128 patients with MI undergoing PCI before and 3 months after the intervention. Results:The results showed a significant decrease in hs-CRP in groups B (11.8 ± 4.3 to 2.0 ± 1 mg/L) and C (11.7±3.9 to 1.3±1.1 mg/L) (P < 0.0001 and P < 0.0001, respectively), but not in group A. Also, a significant reduction was found in IL-6 in groups A (38.0 ± 15 to 9.4 ± 2 pg/mL), B (34.6 ± 12 to 5.1 ± 2.4 pg/mL), and C (33.7 ± 12 to 4.8 ± 2.1 pg/mL) (P < 0.0001, P < 0.0001, and P < 0.0001, respectively). Additionally, LDL and total cholesterol, but not TG, levels significantly decreased in groups A (150 ± 17 to 80 ± 13 mg/dL), B (148 ± 15 to 77.2 ± 14 mg/dL), and C (142 ± 11 to 64.8 ± 10 mg/dL) (P < 0.0001, P < 0.001, and P < 0.0001, respectively). Nevertheless, only group C showed a significant improvement in LVEF (45.1 ± 8 to 53.6 ± 8) (P < 0.027).Conclusions: An adjuvant therapy with TLC diet and supplementation with Q10 and LC seems to be required for secondary prevention following MI and PCI. TLC diet and Q10 plus LC appeared to be effective in inflammatory biomarkers of ISR as well as LDL reduction.

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Role of Pre-procedural C-reactive Protein Level in the Prediction of Major Adverse Cardiac Events in Patients Undergoing Percutaneous Coronary Intervention: a Meta-analysisof Longitudinal Studies

Cited by 22 publications

References 59 publications

High-sensitivity C-reactive protein and mean platelet volume as predictive values after percutaneous coronary intervention for long-term clinical outcomes

High-sensitivity C-reactive protein and mean platelet volume as predictive values after percutaneous coronary intervention for long-term clinical outcomes

Hospitalizations for Acute Myocardial Infarction Are Decreased Among Patients with Inflammatory Bowel Disease Using a Nationwide Inpatient Database

Effects of Therapeutic Lifestyle Change Diet and Q10 Plus L-Carnitine Supplementation on Inflammatory Biomarkers of In-Stent Restenosis, Lipid Profile, and Left Ventricular Ejection Fraction in Myocardial Infarction: A Randomized Clinical Trial

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