“…Our network meta-analysis included 27 RCTs with a total of 1861 patients (median age, 45.99 years [range, 20.00-70.00 years]; 802 women [43.1%]) including 777 patients who used placebo, included in the analysis. 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 The network graphs are presented in Figure 2 and eFigure 1 in Supplement 1 , and the main characteristics of the included studies are reported in Table 1 . The included studies were conducted in Asia (21 studies; 1528 patients), 25 , 27 , 28 , 32 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 45 , 46 , 47 , 48 , 49 , 50 the US (1 study; 86 patients), 43 and Europe (5 studies; 247 patients).…”