Role of probiotics and prebiotics in mitigation of different diseases

Manzoor, Sabeena; Wani, Shoib Mohmad; Mir, Sajad Ahmad; Rizwan, Danish

doi:10.1016/j.nut.2022.111602

Cited by 43 publications

(32 citation statements)

References 156 publications

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“…Prebiotics, mainly dietary fibers, have been used to mitigate various diseases such as gastrointestinal dysfunction and allergic disorders (169). To date, no studies have evaluated the effects of prebiotics in PD patients alone; however, the success of sodium oligomannate (GV-971) for mild-to-moderate AD, which targets the gut microbiota, has provided a promising avenue for mining prebiotics for PD (170,171).…”

Section: Probiotics Psychobiotics Prebiotics Synbiotics and Postbioticsmentioning

confidence: 99%

Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease

Zhu

Liu

et al. 2022

Front. Immunol.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis is involved in the occurrence, development and progression of PD. Numerous clinical trials have identified the characteristics of the changed gut microbiota profiles, and preclinical studies in PD animal models have indicated that gut dysbiosis can influence the progression and onset of PD via increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels of α-synuclein fibrils, increasing oxidative stress, and decreasing neurotransmitter production. The gut microbiota can be considered promising diagnostic and therapeutic targets for PD, which can be regulated by probiotics, psychobiotics, prebiotics, synbiotics, postbiotics, fecal microbiota transplantation, diet modifications, and Chinese medicine. This review summarizes the recent studies in PD-associated gut microbiota profiles and functions, the potential roles, and mechanisms of gut microbiota in PD, and gut microbiota-targeted interventions for PD. Deciphering the underlying roles and mechanisms of the PD-associated gut microbiota will help interpret the pathogenesis of PD from new perspectives and elucidate novel therapeutic strategies for PD.

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Section: Probiotics Psychobiotics Prebiotics Synbiotics and Postbioticsmentioning

confidence: 99%

Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease

Zhu

Liu

et al. 2022

Front. Immunol.

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“…Probiotics are a general term for microorganisms that can improve the microecological balance of the host and play a beneficial role in the intestinal tract [ 521 ]. Regulating the gut microbiota using probiotics may be a good supplementary treatment for obesity and the regulation of lipid metabolism [ 522 – 524 ].…”

Section: Promising Therapy Of Targeting the Gut Microbiota In Cvdsmentioning

confidence: 99%

The role of the gut microbiota in health and cardiovascular diseases

Wang

Zhang

et al. 2022

Mol Biomed

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The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, and producing metabolites to interact with the host. Meanwhile, increasing evidence indicates that the gut microbiota has a strong correlation with the occurrence, progression and treatment of cardiovascular diseases (CVDs). In patients with CVDs and corresponding risk factors, the composition and ratio of gut microbiota have significant differences compared with their healthy counterparts. Therefore, gut microbiota dysbiosis, gut microbiota-generated metabolites, and the related signaling pathway may serve as explanations for some of the mechanisms about the occurrence and development of CVDs. Several studies have also demonstrated that many traditional and latest therapeutic treatments of CVDs are associated with the gut microbiota and its generated metabolites and related signaling pathways. Given that information, we summarized the latest advances in the current research regarding the effect of gut microbiota on health, the main cardiovascular risk factors, and CVDs, highlighted the roles and mechanisms of several metabolites, and introduced corresponding promising treatments for CVDs regarding the gut microbiota. Therefore, this review mainly focuses on exploring the role of gut microbiota related metabolites and their therapeutic potential in CVDs, which may eventually provide better solutions in the development of therapeutic treatment as well as the prevention of CVDs.

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“…On the other hand, different microorganisms might need to grow and reproduce in clusters and symbiotically, its activity could not be guaranteed when a single microorganism was isolated by modern science and technology, which was the main reason ( Castellanos et al, 2020 , Geva-Zatorsky et al, 2017 ). Probiotics have shown significant effects in promoting the digestion and absorption of nutrients, maintaining the homeostasis of gut microbiota, antivirus, inhibiting inflammation, and improving the body's antioxidant and immune capabilities, especially in people with low immunity, constipation, and people who were prone to inflammation ( Manzoor et al, 2022 , Marx et al, 2020 , Su et al, 2020 , Zepeda-Hernández et al, 2021 ). At the same time, the application of probiotics in fishery and breeding industry was also widely used to improve the reproductive ability and immunity of animals ( Golder et al, 2022 , Rohani et al, 2022 ).…”

Section: Research On Active Substances Fermented By Probioticsmentioning

confidence: 99%

Fermented natural product targeting gut microbiota regulate immunity and anti-inflammatory activity: A possible way to prevent COVID-19 in daily diet

Cai

et al. 2022

Journal of Functional Foods

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Role of probiotics and prebiotics in mitigation of different diseases

Cited by 43 publications

References 156 publications

Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease

Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease

The role of the gut microbiota in health and cardiovascular diseases

Fermented natural product targeting gut microbiota regulate immunity and anti-inflammatory activity: A possible way to prevent COVID-19 in daily diet

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