Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer

Fotiadis, C; Stoidis, Christos N.; Spyropoulos, Basileios G.; Zografos, Eleftherios

doi:10.3748/wjg.14.6453

Cited by 156 publications

(91 citation statements)

References 43 publications

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“…In vitro studies have demonstrated that lactic acid bacteria significantly reduce the growth and viability of the human colon cancer cell line HT-29 (39). An in vivo study in laboratory animals have additionally demonstrated that L. acidophilus and B. longum are able to reduce DNA damage and protect against 1,2-dimethylhydrazine-induced genotoxicity (40).…”

Section: Discussionmentioning

confidence: 98%

Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer

Guo

Gao

et al. 2015

Molecular Medicine Reports

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Abstract.Studies using animal models have demonstrated that probiotics may have a beneficial role in the prevention of colorectal cancer (CRC); however, the underlying mechanism of the beneficial effects of interventional probiotic treatment on gut microbiota has remained elusive. In the present study, pyrosequencing of the V3 region of the 16S rRNA genes was conducted in order to determine the extent to which probiotics alter the microbiota. The observations of the present study indicated that the microbial structure of cancerous tissue differed significantly from that of healthy individuals and that the CRC microbiota exhibited lower diversity. It was indicated that interventional treatment with probiotics increased the density and diversity of mucosal microbes, and altered the mucosa-associated microbiota. Pyrosequencing demonstrated that probiotics significantly reduced (5-fold) the abundance of a bacterial taxon assigned to the genus Fusobacterium, which had been previously suggested to be a contributing factor to increase tumorigenesis. Accordingly, interventional probiotic therapy is suggested to be able to improve the composition of the mucosal microbial flora and significantly reduce the abundance of mucosa-associated pathogens in patients with CRC.

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Section: Discussionmentioning

confidence: 98%

Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer

Guo

Gao

et al. 2015

Molecular Medicine Reports

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“…Propionibacterium freudenreichii was shown to induce cell death of human colon and gastric cancer cell lines through secretion of SCFAs in to culture media (Lee et al 2012). Bifidobacteria probiotics reduced colon carcinogenesis induced by 1, 2-dimethylhydrazine in mice when used with FOS and inhibited liver and mammary tumors in rats (Fotiadis et al 2008).…”

Section: Cardiovascular Diseases and Lipid Metabolismmentioning

confidence: 99%

“…Overall, studies in vitro systems and in a wide range of animal models provide considerable evidence that probiotics, prebiotics and synbiotics exert anti-neoplastic effects. (Fotiadis et al 2008).…”

Section: Cardiovascular Diseases and Lipid Metabolismmentioning

confidence: 99%

Probiotics, prebiotics and synbiotics- a review

Pandey¹,

Naik²,

Vakil³

2015

J Food Sci Technol

950

572

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The health benefits imparted by probiotics and prebiotics as well as synbiotics have been the subject of extensive research in the past few decades. These food supplements termed as functional foods have been demonstrated to alter, modify and reinstate the pre-existing intestinal flora. They also facilitate smooth functions of the intestinal environment. Most commonly used probiotic strains are: Bifidobacterium, Lactobacilli, S. boulardii, B. coagulans. Prebiotics like FOS, GOS, XOS, Inulin; fructans are the most commonly used fibers which when used together with probiotics are termed synbiotics and are able to improve the viability of the probiotics. Present review focuses on composition and roles of Probiotics, Prebiotics and Synbiotics in human health. Furthermore, additional health benefits like immune-modulation, cancer prevention, inflammatory bowel disease etc. are also discussed.

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“…66 Providing probiotics with selective fermentable substrates that support their growth (i.e., synbiotics) has been found to produce greater health impacts than either alone. 67,68 Prebiotics such as nondigestible carbohydrates (e.g., galactooligosaccharides (GOS), fructo-oligosaccharides (FOS), resistant starch, polydextrose, and inulin), dietary fibers, and conjugated fatty acids have also been investigated for their role in IBD. 69 In a European study, SYNCAN, a probiotic mixture of Lactobacillus rhamnosus GG (LGG) and B. lactis Bbl2 along with the prebiotic oligofructose-enriched inulin was administered to patients who had undergone a polypectomy or been diagnosed with CRC.…”

Section: ■ Probiotics Prebiotics and Colon Cancermentioning

confidence: 99%

Influence of Dietary Phytochemicals and Microbiota on Colon Cancer Risk

MacDonald

Wagner

2012

J. Agric. Food Chem.

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Colon cancer is the third most commonly diagnosed type of cancer in the United States. Lifestyle and dietary patterns influence colon cancer risk both positively and negatively. Among the dietary factors, several plantderived compounds have been found to afford colon cancer protection. These compounds potentially influence all aspects of colonic cellular regulation and develop complex interrelationships with the colonic microbiome. Increasing understanding of the role of microorganisms in determining the colonic environment has led to awareness of this important interrelationship among dietary factors and the microbial population. Plant-derived polyphenols are active mediators of cellular events, target key carcinogenic pathways, and modulate colonic microbial populations. In turn, the colonic microorganisms metabolize dietary compounds and mediate cellular events. In addition, the role of estrogen receptors in colon cancer and the importance of dietary components that mediate estrogen receptor-β are increasingly being discovered. Hence, dietary bioactive compounds and the intestinal microbiota create a complex milieu that directly affects the carcinogenic events of the colon. These relationships must be carefully characterized in future research to provide dietary recommendations that will reduce colon cancer risk. ABSTRACT: Colon cancer is the third most commonly diagnosed type of cancer in the United States. Lifestyle and dietary patterns influence colon cancer risk both positively and negatively. Among the dietary factors, several plant-derived compounds have been found to afford colon cancer protection. These compounds potentially influence all aspects of colonic cellular regulation and develop complex interrelationships with the colonic microbiome. Increasing understanding of the role of microorganisms in determining the colonic environment has led to awareness of this important interrelationship among dietary factors and the microbial population. Plant-derived polyphenols are active mediators of cellular events, target key carcinogenic pathways, and modulate colonic microbial populations. In turn, the colonic microorganisms metabolize dietary compounds and mediate cellular events. In addition, the role of estrogen receptors in colon cancer and the importance of dietary components that mediate estrogen receptor-β are increasingly being discovered. Hence, dietary bioactive compounds and the intestinal microbiota create a complex milieu that directly affects the carcinogenic events of the colon. These relationships must be carefully characterized in future research to provide dietary recommendations that will reduce colon cancer risk.

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Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer

Cited by 156 publications

References 43 publications

Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer

Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer

Probiotics, prebiotics and synbiotics- a review

Influence of Dietary Phytochemicals and Microbiota on Colon Cancer Risk

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