2021
DOI: 10.3889/oamjms.2021.6137
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Role of Procalcitonin and C-reactive Protein as Marker of Sepsis in Major Burn Patients: A Systematic Review and Meta-analysis

Abstract: AIM: Although absolute values for C-reactive protein (CRP) and procalcitonin (PCT) are well known to predict sepsis, it remains unclear how their diagnostic value in major burn patients as metabolic changes in burn patient mimic signs and symptoms for sepsis. This paper attempts to clarify these points for both of the markers. METHODS: A comprehensive literature search of PubMed, Scopus, DOAJ, Web of Science, and the Cochrane Library databases for studies published up to June 1, 2020, that evaluated PCT and/… Show more

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Cited by 3 publications
(5 citation statements)
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“…Equivalently, Huang et al (2022) reported that PCT is an inflammation marker with high specificity and sensitivity in guiding early clinical diagnosis and prediction of prognosis in burn patients. This was in accordance with several studies reported that PCT was more sensitive and specific in pediatrics and adults than CRP (Samsudin & Vasikaran, 2017;Eschborn & Weitkamp, 2019;Permatasari et al, 2021).…”
Section: Discussionsupporting
confidence: 92%
“…Equivalently, Huang et al (2022) reported that PCT is an inflammation marker with high specificity and sensitivity in guiding early clinical diagnosis and prediction of prognosis in burn patients. This was in accordance with several studies reported that PCT was more sensitive and specific in pediatrics and adults than CRP (Samsudin & Vasikaran, 2017;Eschborn & Weitkamp, 2019;Permatasari et al, 2021).…”
Section: Discussionsupporting
confidence: 92%
“…Early detection of sepsis can facilitate an ideal management and initiate proper antimicrobial therapy Although, Delays in treating infections are associated with poorer outcomes and increased costs Sepsis resulted from burns makes the patient's prognosis worse and raises the possibility of multi-organ dysfunction syndrome (MODS) which is the direct cause of death [1]. Sepsis must be diagnosed as soon as possible because every six hours that pass before a diagnosis reduces survival by 10% [2]. Blood culture remains the gold standard for identifying sepsis, but due to early use of highdose antibiotics, the positive detection rate of blood cultures is extremely low, which will delay the diagnosis [3].…”
Section: Discussionmentioning
confidence: 99%
“…In 2013, Jeschke and his colleagues found, in agreement with the current study, that CRP alone does not predict sepsis or severe infection; however, when used in conjunction with other factors like the cytokine expression profile, hormones, and other proteins, it may be more helpful for the overall evaluation of severely burned patients. Moreover, Permatasari [2] and his co-workers in 2021 according to their results they showed that PCT has a better diagnostic test value than CRP, its use in deciding treatment for patients should be applied with caution and correlated with clinical and other laboratory findings. As in the present study it has been noticed the non-significance role of conventional inflammatory biomarkers, including CRP in detection of sepsis with Median (IQR) 56.1mg/L with p-value >0.05.…”
Section: Discussionmentioning
confidence: 99%
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“…Thus, it is not specific, limiting its use as a marker of sepsis. 11 On the other hand, BC is a specialised investigation that can detect microorganism growth in a patient's blood. It uses an enriched growth medium to support microbial growth and a colourimetric detection system to detect carbon dioxide produced by the growing blood pathogens.…”
Section: Introductionmentioning
confidence: 99%