Role of procalcitonin in detection of bacterial pneumonia

Abed, Suha Maher; Boraqy, Mohammed M. Al; Fatlawi, Sabah Neamah Al

doi:10.5958/0976-5506.2018.01907.1

Cited by 1 publication

(1 citation statement)

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“…Herold et al [22] proposed that even slightly raised IL-6 levels above 80 pg/mL were adequate to recognize COVID-19 patients who were at a significant risk for respiratory failure. Holub et al [23] and Abed et al [24] revealed that compared to viral infection, the levels of TNF-α, PCT and IL-6 were considerably greater in bacterial infection. The same study showed that high IL 6 and TNF-α levels returned to baseline within three days of initiating antibiotic therapy in the control group, which contained healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

The Role of IL-6 and IL-17 in SARS CoV-2 Patients with Secondary Bacterial Pneumonia

Ali¹,

Abed²,

AL-Izzi³

2023

Tikrit J. Pure Sci.

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The current study was conducted in Kirkuk city at Al-Shifaa 14 hospital from November 2021 to March 2022, indicated the bacteria causing secondary pneumonia isolated from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients and the role of IL-6 and IL-17 in these infection. Sputum samples were used to obtain the bacterial isolates, and API testing was used to confirm the species level identification. Using an enzyme-linked immunosorbent assay (sandwich ELISA), the levels of IL-6 and IL-17 in the blood were evaluated. The study documented several bacterial species in a single infection (56/87.5%) or mixed bacterial infection (8/12.5%). The most common isolated bacteria species was Klebsiella pneumoniae (35.95%) followed by Staphylococcus aureus (31.25%), E. coli (17.19%), Pseudomonas aeruginosa (10.94%), and (1.56%) for each of Klebsiella oxytoca, Acinetobacter baumannii and Cronobacter sakazakii. The study recorded a high significant difference (P <0.01) between the patients (22.2±6.82) pg/mL and the control group (58.39±11.15) pg/ mL concerning IL-6 also a high significant difference (P <0.01) between the patients (101.79±27.13) pg/mL and the control group (58.39±11.15) pg/mL concerning IL-17. In conclusion, K. pneumoniae and S. aureus were the predominant isolated bacteria from COVID-19 patient's lung and there was a highly significant increase in IL-6 and IL-17 levels in secondary bacterial pneumonia in COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%