Role of prolactin as a cardiovascular risk in type 2 diabetes mellitus patients: a case-control study in Egypt

Rabie, Walaa; Mohammed, Ahmed F.; Sayed, Sameh G.

doi:10.1007/s13410-015-0344-x

Cited by 1 publication

(1 citation statement)

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“…TSH levels have previously been implicated in the development of insulin resistance (IR) and diabetes while TNF-α has been shown to decrease appetite, therefore, lower levels of TNF-α may exasperate obesity related comorbidities by lending to increased positive energy imbalance ( 20 – 22 ). Amylin is known to be associated with development of type 1 and TIID and increased prolactin levels have been shown to be a cardiovascular risk factor with correlations to diabetes as well ( 23 – 26 ). However, our previous study was performed with only 58 individuals (29 FA obese, 29 NFA obese).…”

Section: Introductionmentioning

confidence: 99%

The Association Between an Addictive Tendency Toward Food and Metabolic Characteristics in the General Newfoundland Population

et al. 2018

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Background: Our previous study of 29 obese food addiction (FA) patients found that FA is associated with lipid profiles and hormones which may be a factor in cardiovascular disease (CVD) and insulin resistance (IR). However, there is currently no data available regarding the relationship between FA symptoms and metabolic characteristics of CVD and IR in the general population. We designed this study to investigate the correlation between FA symptoms with lipid profiles and IR in men and women of the general Newfoundland population.Methods: 710 individuals (435 women and 275 men) recruited from the general Newfoundland population were used in analysis. FA symptoms were evaluated using the Yale Food Addiction Scale (YFAS). Glucose, insulin, HDL, LDL, total cholesterol and triglycerides levels were measured. IR was evaluated using the homeostatic model of assessment (HOMA). Participants were grouped by sex and menopausal status. Age, physical activity, calories and total % body fat were controlled.Results: Partial correlation analysis revealed that in men, YFAS symptom counts were significantly correlated with HOMA-β (r = 0.196, p = 0.021), triglycerides (r = 0.140, p = 0.025) and inversely correlated with HDL (r = −0.133, p = 0.033). After separating by menopausal status, pre-menopausal women exhibited no correlations and post-menopausal women had a significantcorrelation with triglycerides (r = 0.198, p = 0.016).Conclusion: FA is significantly correlated with several markers of metabolic disturbance in men and to a lesser extent, post-menopausal women, in the general population. Further research is required to explain sex specific associations and elucidate any potentially causal mechanisms behind this correlation.

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