Role of Prostaglandin E₂ in the Modulation of Wnt Canonical Signaling in Cells on Microstructured Titanium Surfaces

Abstract

Prostaglandin signaling affects the activation of Wnt canonical pathway in osteoblastic and mesenchymal cells on microstructured surfaces.

Effects of the micro–nano surface topography of titanium alloy on the biological responses of osteoblast

“…Galli et al found that rough surfaces enhanced the activation of Wnt/β‐catenin signaling in mesenchymal cells through enhancing the stimulation of β‐catenin/TCF signaling and promoting β‐catenin translocation to the nucleus, and also controling the expression of Axin 2, a protein that mediates β‐catenin degradation. Furthermore, a key mechanism that mediates rough surface effects on cell differentiation is modulation of cyclooxygenase actvity, and thus production and release of prostaglandins, which are known to be released in response to mechanical stimulation, helping control Wnt canonical pathways in osteoblastic cells growing on titanium surfaces with different topographies . Rough surface topography enhances the activation of Wnt canonical signaling, a pathway required for osteoblast differentiation.…”

Thermal-induced hydrophilicity enhancement of titanium dental implant surfaces

“…Furthermore, the biological aging of titanium, according to hydrophilicity and more generally, biological performances of titanium surfaces, tends to decrease after the processing procedures and is still an unsolved issue [18][19][20][21].…”

Qelizat burimore mezenkimale, reagimi ndaj sipërfaqeve implantare drejt osteointegrimit

“…Mё poshtё po paraqesim 41 artikujt e pёrzgjedhur: Artikuj ku ёshtё vlerёsuar efekti i modulimit tё sipёrfaqes implantare in vitro tek mostra grup qelizash tё marra nga minjtё, nё total janё 9 artikuj. (27)(28)(29)(30)(31)(32)(33)34,35,36) Artikuj ku ёshtё vlerёsuar efekti i modulimit tё sipёrfaqes implantare in vivo tek mostra grup qelizash tё marra nga minjtё, nё total janё 8 artikuj. (37-41, 42, 43) Artikuj ku ёshtё vlerёsuar efekti i modulimit tё sipёrfaqes implante in vitro tek mostra grup qelizash tё marra nga pacientёt, nё total janё 20 artikuj.…”

“…Ilma Robo, Saimir Heta, Dhimitri Papakozma, Vera Ostreni (30)(31)(32)(33)(34) Eksperimente të shumtë janë kryer në kafshë për të parë sesi ndikon modifikimi i sipërfaqes implantare në arritjen e osteintegrimit të nevojshëm për stabilitet implantar. Tek këto studime të sponsorizuara nga fimrat e prodhimit të implanteve, vihet re theksi tek materiali i përdorur mbi sipërfaqen e implanteve.…”