“…In addition, in isolated rat hearts it has been shown that PGI2 has a concentration-dependent anti-arrhythmic action (10), suggesting that PGI2 has intrinsic anti-dysrhythmic action. Furthermore, PGE2 is known to regulate PGI2 synthesis (11,12). Thus, as PGE2 levels rise, PGI2 levels fall and vice versa.…”