1983
DOI: 10.1038/jcbfm.1983.54
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Role of Prostaglandins in the Response of the Cerebral Circulation to Carbon Dioxide in Conscious Rabbits

Abstract: Summary:The role of prostaglandins in maintenance of resting cerebral blood flow (CBF) and in cerebral vaso dilatation during hypercapnia remains controversial. The effect of indomethacin, a cyclo-oxygenase inhibitor, on CBF and cerebrovascular resistance (CVR) was exam ined in conscious animals. Regional and total CBF were measured with radioactive microspheres, and the efficacy of blockade of prostaglandin synthesis by indomethacin was examined by the cranial window method. CBF was measured in conscious rabb… Show more

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Cited by 28 publications
(7 citation statements)
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“…Similarly, studies in adult primates, rats, and gerbils found inhibition of hypercapnic vasodilation after indomethacin (1 5-17). On the other hand, some investigators using rabbits, dogs, and cats were unable to detect an effect of indomethacin on hypercapnic cerebral vasodilation (18)(19)(20)(21)(22), whereas others reported inhibition of hypercapnic cerebral vasodilation after indomethacin in these same three species (23)(24)(25)(26)(27).…”
Section: Resultsmentioning
confidence: 99%
“…Similarly, studies in adult primates, rats, and gerbils found inhibition of hypercapnic vasodilation after indomethacin (1 5-17). On the other hand, some investigators using rabbits, dogs, and cats were unable to detect an effect of indomethacin on hypercapnic cerebral vasodilation (18)(19)(20)(21)(22), whereas others reported inhibition of hypercapnic cerebral vasodilation after indomethacin in these same three species (23)(24)(25)(26)(27).…”
Section: Resultsmentioning
confidence: 99%
“…In addition, some investigators obtained similar results using cats, rabbits, and dogs (Vlahov, 1976;Ruszczewski and Herbaczynska-Cedro, 1978;BUI, 1979;Shigeno et al, 1983;Pinard, 1983). On the other hand, others have found that indomethacin, at doses that block vasodilatory responses of pial vessels to exogenous arachidonic acid, did not affect cerebral blood flow, pial artery diameter, or responses of cerebral arteries to hypercapnia in adult cats, rabbits, or dogs (Wei et al, 1980;Busija, 1983;Busija and Heistad, 1983;Jackson et al, 1983). Further, in adult animals, the cerebral vasodilator response to arterial hypoxia was consistently unaltered by intravenous administration of indomethacin (Sakabe and Siesjo, 1979;Wei et al, 1980).…”
Section: Discussionmentioning
confidence: 99%
“…Investigators using adult primates, rats, and gerbils have found that systemic administration of indomethadn decreases cerebral blood flow during normocapnia and reduces the hyperemia induced by hypercapnia (Pickard and MacKenzie, 1973;Sakabe and Siesjo, 1979;Crockard et al, 1982). Conversely, several investigators using rabbits, dogs, and cats have been unable to detect alterations in resting cerebral blood flow and pial arterial diameter or in the responses to hypercapnia or hypoxia following systemic treatment with indomethadn (Wei et al, 1980;Busija, 1983;Busija and Heistad, 1983;Jackson et al, 1983), whereas others reported changes similar to those found in primates, rats, and gerbils after treatment of dogs (Ruszczewski and Herbaczynska-Cedro, 1978), cats (Vlahoo, 1976;Shigeno et al, 1983), and rabbits (Bill, 1979;Pinard, 1983) with indomethadn. Further, measurements of prostanoids in cerebral venous blood and brain tissue have not revealed changes in cerebral prostanoid synthesis during alterations in blood gases (Ellis et al, 1982;Eriksson et al, 1983;Jackson et al, 1983;McCalden et al, 1984).…”
Section: Prostanoids In Cortical Subarachnoid Cerebrospinal Fluid Andmentioning
confidence: 99%
“…The direct action of C 0 2 and various other mediators, such as perivascular pH and bicarbonate ion, on the cerebral vessel wall remains controversial, and prostanoids have been recently implicated (33). Indomethacin, a prostaglandin synthetase inhibitor, has been found to abolish this response in preterm infants (34), as well as in rats (35) and gerbils (36), although not in some other experimental animals (37). It is possible that alterations in the concentrations of prostanoids in brain tissue or vessel wall may account for the effect of gestational age on CBVR, but to our knowledge no data are available from human infants.…”
Section: Materlals and Methodsmentioning
confidence: 99%