Role of protective Pelargonium Sidoides root extract and Curcumin on Mushroom poisoning: An Experimental study in rats

Ünsal, Velid; Kurutas, EB; Güngör, Meltem; Emrah, Aksan M

doi:10.5138/09750185.2050

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…This may protect the liver cells from damage and improve the function after damage. Unsal et al [66] revealed that the antioxidant and detoxification properties of P. reinforme/sidoides extract against mushroom poisoning is through reduction of malondialdehyde, increasing Paraoxonase levels and regulating purine metabolism thus reducing ROS. The extract of P. reinforme/sidoides also significantly decreased levels of liver enzyme markers (AST, ALT, ALP and GGT) indicating that the extract possessed a curative effect.…”

Section: Discussionmentioning

confidence: 99%

Experimental in vivo assessment of immunomodulatory effect of Kalobin (Pelargonium reinforme/sidoides extract) on schistosomiasis mansoni

Menaem

Mostafa

Sarhan

et al. 2022

Parasitologists United Journal

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Background: Schistosomiasis is a major tropical disease with significant morbidity and mortality in several developing countries. Hence, searching for a new immunomodulating supportive aid for the sole drug of choice, praziquantel (PZQ), is an important target. Objective: The aim of the present work is to assess the immunomodulatory effect of Kalobin (Pelargonium reinforme/sidoides extract) on schistosomiasis mansoni in vivo. Material and Methods: Swiss albino mice were infected with S. mansoni cercariae and were divided into two major categories, immunocompetent (IC) and immunosuppressed (IS). Immunosuppression was performed 14 successive days prior to infection. Kalobin and PZQ, either individually or combined, were given orally seven weeks post infection (wpi). Only in IC mice, both drugs were given in a combination of 100 mg/kg seven wpi for five consecutive days as a preliminary trial. Other groups were treated with PZQ (IC2, 50 mg/kg and IC1, 200 mg/kg) or Kalobin (IC3, 200 mg/kg) or combined PZQ-Kalobin treatment (IC4, 50 mg/kg each) for five consecutive days. This regimen was administered to both IC and IS subgroups and compared to the negative uninfected non-treated control subgroup and the two corresponding positive infected non-treated control CIC and CIS subgroups. All mice were sacrificed 9 wpi for assessment of parasitological parameters including total worm burden (TWB), tissue egg load, oogram pattern, and measurement of hepatic granuloma number and size. Immunohistochemical procedure was employed to assess the expression of vascular endothelial growth factor (VEGF) in both hepatocytes and sinusoids. Results: Therapy with combined treatment (IC5, 100 mg/Kg each) proved to be superior to the sole PZQ treatment (IC1, 200 mg/kg and IC2, 50 mg/kg) as shown by its effect on TWB and oogram pattern and greater reduction in intestinal and hepatic egg counts in IS groups. Combined PZQ-Kalobin therapy (IC4, 50 mg/kg each) approached the higher individual PZQ dose (IC1, 200 mg/kg) in reducing the granuloma number. The highest reduction in the expression of VEGF in hepatocytes and sinusoids was recorded in the combined PZQ-Kalobin (IC4 and IS4, 50 mg/kg each) followed by subgroup IC3 (Kalobin 200 mg/kg) then IC1 (PZQ 200 mg/kg). Moreover, as regards the IS subgroups; IS4, PZQ-Kalobin 50 mg/kg combination and IS3, Kalobin 200 mg/kg showed better results than all IC subgroups. Individual Kalobin in (IS3) subgroup showed better response than in IC3 subgroup using the same dose of 200 mg/kg. Conclusion: Our study highlighted the immunopotentiating outcome for Kalobin whether in combination with PZQ or individually on schistosomiasis mansoni in vivo.

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Section: Discussionmentioning

confidence: 99%

Experimental in vivo assessment of immunomodulatory effect of Kalobin (Pelargonium reinforme/sidoides extract) on schistosomiasis mansoni

Menaem

Mostafa

Sarhan

et al. 2022

Parasitologists United Journal

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“…These agents have antioxidants, free radical scavengers and anti-toxic properties. 16 , 23 , 131 - 132 …”

Section: Discussionmentioning

confidence: 99%

Natural Phytotherapeutic Antioxidants in the Treatment of Mercury Intoxication-A Review

Ünsal¹

2018

Adv Pharm Bull

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Heavy metals taken into the organism can make the toxic effects on the metabolism in various ways. For example, they may interact with proteins to alter and inhibit their enzymatic and structural functions. Mercury is one of the toxic elements that are widely distributed in nature. Mercury toxicity poses a serious threat to human health. It is an element that causes oxidative stress to increase in individuals, leading to tissue damage. Oxidative stress is the result of the imbalance between the production of oxidative species and cellular antioxidant defense. Phytotherapy continues to play an important role in health care. Natural phytotherapeutic antioxidants, exhibit a broad sequence of biological impacts, including anti-oxidative stress, anti-aging, anti-toxicicity and anticancer. Many studies have also shown that the phytotherapeutic agents play an important role in the removal of mercury from the tissue and in reducing oxidative stress. Our goal in this review was to investigate alternative ways of extracting the mercury in the tissue.

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Role of protective Pelargonium Sidoides root extract and Curcumin on Mushroom poisoning: An Experimental study in rats

Cited by 2 publications

References 14 publications

Experimental in vivo assessment of immunomodulatory effect of Kalobin (Pelargonium reinforme/sidoides extract) on schistosomiasis mansoni

Experimental in vivo assessment of immunomodulatory effect of Kalobin (Pelargonium reinforme/sidoides extract) on schistosomiasis mansoni

Natural Phytotherapeutic Antioxidants in the Treatment of Mercury Intoxication-A Review

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