2020
DOI: 10.2174/1874312902014010015
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Role of Protein Tyrosine Phosphatase (PTPN22) Gene [C1858T] Functional Variant in Genetic Susceptibility of Psoriatic Arthritis in Kuwaiti Arabs

Abstract: Background: Psoriatic arthritis (PsA) is a chronic, systemic inflammatory arthritic disease characterized by joint inflammation that is associated with cutaneous psoriasis, and can lead to pain, swelling, or stiffness in one or more joints. It results from a complex interplay between genetic, immunologic and environmental factors. A functional variant [C1858T] in the protein tyrosine phosphatase (PTPN22) gene, which encoded Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP) has been shown t… Show more

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Cited by 2 publications
(2 citation statements)
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“… 35 Also, Chen and Chang 36 showed a non-significant positive association between psoriasis and PTPN22 1858 T-allele, and the association appeared more strong among subjects with psoriatic arthritis. Recently, Al-Awadhi et al 37 stated that the frequency of homozygous genotype (TT) was significantly higher in PsA patients compared to controls ( p <0.0001) in Kuwaiti Arabs. However, previous studies from various geographical regions/ethnic populations on PTPN22 (+1858C/T) polymorphism and psoriasis have reported inconsistent conclusions, indicating that this association might be disease- and population-specific.…”
Section: Discussionmentioning
confidence: 99%
“… 35 Also, Chen and Chang 36 showed a non-significant positive association between psoriasis and PTPN22 1858 T-allele, and the association appeared more strong among subjects with psoriatic arthritis. Recently, Al-Awadhi et al 37 stated that the frequency of homozygous genotype (TT) was significantly higher in PsA patients compared to controls ( p <0.0001) in Kuwaiti Arabs. However, previous studies from various geographical regions/ethnic populations on PTPN22 (+1858C/T) polymorphism and psoriasis have reported inconsistent conclusions, indicating that this association might be disease- and population-specific.…”
Section: Discussionmentioning
confidence: 99%
“…The diagnosis of PsA was made as per the guidelines described earlier [27]. The details about diagnosis, patient characteristics and selection of controls have been reported in our earlier report [28]. Briefly, the PsA patients, manifested inflammatory arthritis associated with psoriasis and were negative for rheumatoid factor in the serum.…”
Section: Methodsmentioning
confidence: 99%