Role of Proximal Intestinal Glucose Sensing and Metabolism in the Blood Glucose Control in Type 2 Diabetic Rats After Duodenal Jejunal Bypass Surgery

Jiang, Bin; Wang, Huaijie; Li, Na; Yan, Qingtao; Wang, Weiyu; Wang, Yubing; Xue, Hantao; Ma, Shengyao; Li, Xiaocheng; Diao, Wenbin; Pan, Ruiyan; Gao, Zhiqin; Qu, Mei-Hua

doi:10.1007/s11695-021-05871-3

Cited by 5 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies were conducted in rats (13 studies), mice (seven studies) or both (one study). The bariatric procedure was RYGB in nine studies [ 50 – 58 ], duodenal-jejunal bypass (DJB) in four studies [ 59 – 62 ], sleeve gastrectomy (SG) in seven studies [ 50 , 63 – 67 ], and entero-gastric anastomosis (EGA) procedures [ 35 ], single-anastomosis duodenal-jejunal bypass (SA-DJB) [ 68 ], and ileal interposition (IIP) [ 69 ] in one study each. Five studies included analysis of animals with diabetes or insulin resistance [ 54 , 61 , 62 , 67 , 69 ].…”

Section: Resultsmentioning

confidence: 99%

“…Time between surgery and tissue harvest ranged between 11 days and six months. Taste receptor quantification was carried out using PCR for mRNA analysis in six studies [ 35 , 50 , 54 , 57 , 58 , 61 ], protein analysis techniques (such as Western blotting, immunohistochemistry, or mass spectrometry) in another five [ 52 , 53 , 56 , 68 , 69 ], or both in 10 studies [ 51 , 55 , 59 , 60 , 62 – 67 ]. Key characteristics of animal studies are outlined in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review

Walmsley,

Chong,

Hii

et al. 2024

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Gastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and fatty foods following bariatric surgery. This review aimed to investigate the effect of bariatric surgery on the expression of oral and post-oral gastrointestinal taste receptors and associations between taste receptor alterations and clinical outcomes of bariatric surgery. A systematic review was conducted to capture data from both human and animal studies on changes in the expression of taste receptors in oral or post-oral gastrointestinal tissue following any type of bariatric surgery. Databases searched included Medline, Embase, Emcare, APA PsychInfo, Cochrane Library, and CINAHL. Two human and 21 animal studies were included. Bariatric surgery alters the quantity of many sweet, umami, and fatty acid taste receptors in the gastrointestinal tract. Changes to the expression of sweet and amino acid receptors occur most often in intestinal segments surgically repositioned more proximally, such as the alimentary limb after gastric bypass. Conversely, changes to fatty acid receptors were observed more frequently in the colon than in the small intestine. Significant heterogeneity in the methodology of included studies limited conclusions regarding the direction of change in taste receptor expression induced by bariatric surgeries. Few studies have investigated associations between taste receptor expression and clinical outcomes of bariatric surgery. As such, future studies should look to investigate the relationship between bariatric surgery-induced changes to gut taste receptor expression and function and the impact of surgery on taste preferences, food palatability, and eating behaviour.Registration code in PROSPERO: CRD42022313992

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review

Walmsley,

Chong,

Hii

et al. 2024

Rev Endocr Metab Disord

View full text Add to dashboard Cite

show abstract

“…In the present study, changes in glucose transporter expression in AL suggested that much amount of absorbed glucose could remain within epithelial cells, supporting the previous study that increased glucose uptake into the intestinal mucosa is important for intestinal remodeling. On the contrary, Jiang et al reported that the SGLT1 expression in AL was downregulated 6 weeks after DJB surgery and suggested decreased intestinal glucose uptake could induce intestinal remodeling 37 . These conflicting findings suggest that the mechanism leading to improvement of T2DM may be different between early and later postoperative periods.…”

Section: Discussionmentioning

confidence: 97%

Effect of duodenal-jejunal bypass on diabetes in the early postoperative period

Okikawa

Kashihara

Shimada

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.

show abstract

“…Combined with the finding mentioned above that the activity of SGLT1 expression in the duodenum of GK rats was stronger than that in ZDF rats (Figures 4,5), we speculated that unlike ZDF rats in early diabetes, the regulation pathway of SGLT1-GLP-1R in GK rats with advanced diabetes may have been blocked. The differences seen in diabetic rats with varying durations may have been due to complex pathophysiological conditions, which may account for the lower remission rate or higher recurrence rate after surgery in diabetic patients with longer durations (42,77). Therefore, an intact SGLT1-GLP-1R regulation pathway might be an important indication for the "surgical diabetes" (44) that we have proposed.…”

Section: Sglt1 May Synergically Regulate Glp-1 Expression and Glucone...mentioning

confidence: 96%

“…Further, the mRNA expression of SGLT1 in the jejunum of GK rats was higher than in ZDF rats (Figure 6), indicating the probability that the longer the duration of diabetes, the higher the expression of SGLT1 in the "foregut". Differences in SGLT1 expression levels should be regarded as distinct pathophysiological states of diabetes (75)(76)(77) and is worthy of further study involving humans with different duration of diabetes.…”

Section: Distinct Pathophysiological Conditions Might Account For The...mentioning

confidence: 99%

Sodium-glucose co-transporter 1 (SGLT1) differentially regulates gluconeogenesis and GLP-1 receptor (GLP-1R) expression in different diabetic rats: a preliminary validation of the hypothesis of “SGLT1 bridge” as an indication for “surgical diabetes”

Zhu¹,

Cai²,

Wang³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background: Sodium-glucose co-transporter 1 (SGLT1) may play a synergistic role in gluconeogenesis (GNG) and glucagon-like peptide-1 (GLP-1) expression. We proposed the hypothesis of a "SGLT1 bridge" as an indication for "surgical diabetes" that was preliminary validated in the present study. Methods:We selected nonobese diabetic Goto-Kakizaki (GK) rats and Zuker diabetic fat (ZDF) rats to represent advanced and early diabetes, respectively. Based on glucose gavage with or without SGLT1 inhibitor phlorizin, the rats were divided into 4 groups: Gk-Glu, GK-P, ZDF-Glu, and ZDF-P. The expressions of SGLT1, GLP-1 receptor (GLP-1R), glucose-6 phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase-1 (Pck1) were determined by immunohistochemistry (IHC) or quantitative reverse transcription polymerase chain reaction (RT-qPCR), and the effects of phlorizin were analyzed.Results: Glucose tolerance was worse in GK rats and the homeostasis model assessment-insulin resistance (HOMA-IR) was higher in ZDF rats, indicating different pathophysiological conditions between the different diabetic rats. GK rats showed higher activity of duodenal SGLT1 (P=0.022) and jejunal SGLT1 mRNA expression (P=0.000) and lower SGLT1 mRNA expression in the liver (P=0.000) and pancreas (P=0.000). Phlorizin effectively inhibited the activity of duodenal SGLT1 in both GK rats (P=0.000) and ZDF rats (P=0.000). In ZDF rats, the expression of GLP-1R mRNA was downregulated in the jejunum (P=0.001) and upregulated in the pancreas (P=0.021) by phlorizin, but there were no regulatory effects on GLP-1R mRNA in the jejunum and pancreas of GK rats. As for the regulatory effects on GNG, phlorizin upregulated Pck1 mRNA in the duodenum (P=0.000) and the jejunum (P=0.038), whereas it downregulated hepatic G6Pase mRNA in ZDF rats (P=0.005) and Pck1 mRNA expression in GK rats (P=0.001), suggesting that SGLT1 inhibitor may have upregulated intestinal GNG in ZDF rats and downregulated hepatic GNG in both ZDF and GK rats.Conclusions: SGLT1 showed synergistic regulatory effects on the entero-insular axis (EIA) and the gut-brain-liver axis (GBLA), preliminarily validating the hypothesis of a "SGLT1 bridge". The distinct ^ ORCID: 0000-0003-0111-677X.

show abstract

Role of Proximal Intestinal Glucose Sensing and Metabolism in the Blood Glucose Control in Type 2 Diabetic Rats After Duodenal Jejunal Bypass Surgery

Cited by 5 publications

References 30 publications

The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review

The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review

Effect of duodenal-jejunal bypass on diabetes in the early postoperative period

Sodium-glucose co-transporter 1 (SGLT1) differentially regulates gluconeogenesis and GLP-1 receptor (GLP-1R) expression in different diabetic rats: a preliminary validation of the hypothesis of “SGLT1 bridge” as an indication for “surgical diabetes”

Contact Info

Product

Resources

About