Role of pyroptosis in atherosclerosis and its therapeutic implications

He, Binglin; Nie, Qiangqiang; Wang, Rui; Han, Yongxin; Yang, Bo; Sun, Mingsheng; Fan, Xueqiang; Ye, Zhidong; Wen, Jianyan

doi:10.1002/jcp.30366

Cited by 42 publications

(32 citation statements)

References 164 publications

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“…According to recent research, pyroptosis has an impact on the entire course of atherosclerosis [ 47 ]. Therefore, appropriate intervention in the activation of pyroptosis in atherosclerotic plaques may provide a new therapeutic strategy for patients with AS [ 48 ]. To predict effective therapeutic agents for atherosclerotic plaques, the DGIdb was used to identify drugs and molecular compounds that affect upregulated hub genes in the two pyroptosis-related clusters.…”

Section: Discussionmentioning

confidence: 99%

Pyroptosis-Related Gene Signature and Expression Patterns in the Deterioration of Atherosclerosis

Ma²,

Wang

et al. 2022

Disease Markers

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Background. Pyroptosis has been shown to be involved in the overall process of atherosclerosis. This study was aimed at investigating pyroptosis-related gene expression patterns in atherosclerosis and their diagnostic significance. Methods and Results. In GSE100927, fifty-four pyroptosis-related genes were identified. Between atherosclerotic plaques and normal samples, the expression patterns of pyroptosis-related genes were significantly different. In order to construct a pyroptosis-related risk score signature (PRSS), the least absolute shrinkage and selection operator (LASSO) was combined with multivariate logistic regression to screen twelve genes. The diagnostic efficiency of the PRSS performed well in GSE43292, as shown by the results of receiver-operating characteristics (ROCs). Consensus clustering identified two expression patterns of pyroptosis-related genes in different statuses of atherosclerotic plaque in GSE163154. The biological behavior of the different clusters was examined by the gene set variation analysis (GSVA). The Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses revealed that the differentially expressed genes (DEGs) in the two clusters were enriched in the immune response. The Cytoscape software was used to construct protein-protein interaction (PPI) networks for hub gene screening. Following that, the Drug Gene Interaction Database (DGIdb) was utilized to find 47 possible medicines and chemical compounds that interact with hub genes in atherosclerotic plaques. Conclusion. The results of this study showed that pyroptosis-related genes contribute to the progression of atherosclerosis and may serve as biomarkers in clinical diagnosis as well as novel therapeutic targets for the treatment of AS.

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Section: Discussionmentioning

confidence: 99%

Pyroptosis-Related Gene Signature and Expression Patterns in the Deterioration of Atherosclerosis

Ma²,

Wang

et al. 2022

Disease Markers

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“…The pathogenesis of atherosclerosis involves smooth muscle cell proliferation and migration, endothelial cell dysfunction, pro-inflammatory cytokine secretion, and cell death 56 . Previous studies have illustrated that pyroptosis in macrophages, endothelial cells, and smooth muscle cells are related to the progression of atherosclerosis 57 . Duewell et al showed that cholesterol crystals can activate caspase-1 through the NLRP3 inflammasome, which cleaves pro-IL-18 and pro-IL-1β to produce their mature forms, resulting in inflammation and atherosclerosis formation 58 .…”

Section: Inhibiting Pyroptosis To Treat Inflammatory Diseasesmentioning

confidence: 99%

Pyroptosis in inflammatory diseases and cancer

et al. 2022

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Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered by inflammasomes and executed by gasdermin proteins. The main characteristics of pyroptosis are cell swelling, membrane perforation, and the release of cell contents. In normal physiology, pyroptosis plays a critical role in host defense against pathogen infection. However, excessive pyroptosis may cause immoderate and continuous inflammatory responses that involves in the occurrence of inflammatory diseases. Attractively, as immunogenic cell death, pyroptosis can serve as a new strategy for cancer elimination by inducing pyroptotic cell death and activating intensely antitumor immunity. To make good use of this double-edged sword, the molecular mechanisms, and therapeutic implications of pyroptosis in related diseases need to be fully elucidated. In this review, we first systematically summarize the signaling pathways of pyroptosis and then present the available evidences indicating the role of pyroptosis in inflammatory diseases and cancer. Based on this, we focus on the recent progress in strategies that inhibit pyroptosis for treatment of inflammatory diseases, and those that induce pyroptosis for cancer therapy. Overall, this should shed light on future directions and provide novel ideas for using pyroptosis as a powerful tool to fight inflammatory diseases and cancer.

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“…Morphologically, it is most likely to be a combination of apoptosis and necrosis. The pathogenesis of atherosclerosis is characterized by recruitment of monocytes and lymphocytes, dysfunction of ECs, formation of foam cells (FCs), proliferation of smooth muscle cells (SMCs), secretion of proinflammatory cytokines, accumulation and oxidation of LDL, adherence of platelets, and death of abundant cells [7] [81]. Previous studies have confirmed that atherosclerosis is mainly attributed to inflammation and the products of pyroptosis such as IL-1β, IL-18, IL-1α, ATP, and GSDMD-N, suggesting crucial role of pyroptosis in the pathogenesis of atheroscle-rosis [21][82] [83].…”

Section: Pyroptosis In Atherosclerosismentioning

confidence: 99%

Pyroptosis in NLRP3 inflammasome-related atherosclerosis

Zeng¹,

Liu²,

Huo³

et al. 2022

CST

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Pyroptosis is a proinflammatory form of programmed cell death in response to inﬂammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment.

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Role of pyroptosis in atherosclerosis and its therapeutic implications

Cited by 42 publications

References 164 publications

Pyroptosis-Related Gene Signature and Expression Patterns in the Deterioration of Atherosclerosis

Pyroptosis-Related Gene Signature and Expression Patterns in the Deterioration of Atherosclerosis

Pyroptosis in inflammatory diseases and cancer

Pyroptosis in NLRP3 inflammasome-related atherosclerosis

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