Role of quantitative chest perfusion computed tomography in detecting diabetic pulmonary microangiopathy

Novel Methods for Diagnosis of Pulmonary Microangiopathy in Diabetes Mellitus

“…Therefore mean perfusion parameters were calculated for all 18 ROIs. The results are shown in Table 8 (Kuziemski et al, 2011). Here a noticeable increase was observed in the parenchyma perfusion parameter values of the diabetics with respect to control group, which may be due to diabetic mellitus.…”

“…All perfusion parameters were calculated in 18 in the parenchyma to discover whether parameter values depend on the location of tested lung cross-section. Statistical analysis revealed no correlation between perfusion parameter value and ROI location in the upper central or lower part of the lungs (Kuziemski et al, 2011). Therefore mean perfusion parameters were calculated for all 18 ROIs.…”

“…Perfusion computed tomography (pCT) is a diagnostic method that enables the imaging of the organ and tissue. This is a powerful tool for diagnosing perfusion of internal organs such as the brain, liver, pancreas, spleen, kidneys and lungs (Alonzi & Hoskin, 2006), (Blomley et al, 1993), (Cao, 2011), (Eichinger et al, 2010), (Kuziemski et al, 2011). The method enables quantitative evaluation of circulation by determining changes in tissue during the flow of a contrast agent in the blood vessels.…”

“…Changes, when compared to a normal tissue, can indicate tissue pathology. Lung pCT measurements can help in the diagnosis of cystic fibrosis (Eichinger et al, 2010) and diabetes (Kuziemski et al, 2011). It can also help to differentiate benign pulmonary nodules from lung cancer (Alonsi & Hoskin, 2006).…”

“…There are a number of pulmonary perfusion parameters, calculated pixel by pixel on the basis of raw CT data, which are next analysed in order to reveal differences between the normal and altered tissue. The most useful perfusion parameters are: blood volume (BV), blood flow (BF), mean transit time (MTT), time to peak (TTP) and permeability surface (PS) (Kuziemski et al, 2011). The diagnosis of pulmonary function has to be based on indirect results, such as diffusing capacity, spirometry and pCT because direct assessment is difficult.…”