Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal

Castagnoli, Helga; Ferrantini, Cecilia; Coppini, Raffaele; Passeri, Alessandro; Baldini, Katia; Berti, Valentina; Cecchi, Francesca; Olivotto, Iacopo; Sciagrà, Roberto

doi:10.1007/s00259-016-3465-7

Cited by 20 publications

(20 citation statements)

References 38 publications

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“…However, we additionally found that perfusion abnormalities could even be present in segments that were non-hypertrophied and contained no LGE 12 13. To our knowledge, this is the largest CMR quantitative perfusion study, with prior cohorts including 30–40 patients and similar to the largest quantitative PET study of 100 patients 28…”

Section: Discussionmentioning

confidence: 56%

Inline perfusion mapping provides insights into the disease mechanism in hypertrophic cardiomyopathy

Camaioni

Knott

Augusto

et al. 2019

Heart

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ObjectiveIn patients with hypertrophic cardiomyopathy (HCM), the role of small vessel disease and myocardial perfusion remains incompletely understood and data on absolute myocardial blood flow (MBF, mL/g/min) are scarce. We measured MBF using cardiovascular magnetic resonance fully quantitative perfusion mapping to determine the relationship between perfusion, hypertrophy and late gadolinium enhancement (LGE) in HCM.Methods101 patients with HCM with unobstructed epicardial coronary arteries and 30 controls (with matched cardiovascular risk factors) underwent pixel-wise perfusion mapping during adenosine stress and rest. Stress, rest MBF and the myocardial perfusion reserve (MPR, ratio of stress to rest) were calculated globally and segmentally and then associated with segmental wall thickness and LGE.ResultsIn HCM, 79% had a perfusion defect on clinical read. Stress MBF and MPR were reduced compared with controls (mean±SD 1.63±0.60 vs 2.30±0.64 mL/g/min, p<0.0001 and 2.21±0.87 vs 2.90±0.90, p=0.0003, respectively). Globally, stress MBF fell with increasing indexed left ventricle mass (R2 for the model 0.186, p=0.036) and segmentally with increasing wall thickness and LGE (both p<0.0001). In 21% of patients with HCM, MBF was lower during stress than rest (MPR <1) in at least one myocardial segment, a phenomenon which was predominantly subendocardial. Apparently normal HCM segments (normal wall thickness, no LGE) had reduced stress MBF and MPR compared with controls (mean±SD 1.88±0.81 mL/g/min vs 2.32±0.78 mL/g/min, p<0.0001).ConclusionsMicrovascular dysfunction is common in HCM and associated with hypertrophy and LGE. Perfusion can fall during vasodilator stress and is abnormal even in apparently normal myocardium suggesting it may be an early disease marker.

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Section: Discussionmentioning

confidence: 56%

Inline perfusion mapping provides insights into the disease mechanism in hypertrophic cardiomyopathy

Camaioni

Knott

Augusto

et al. 2019

Heart

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“…Positron emission tomography (PET) with either O 15 -labeled water or N 13 -labeled ammonia is the most reliable method for imaging myocardial blood flow (MBF) in HCM. 34,35 Measurements of MBF by PET at rest and during maximal vasodilation have demonstrated marked limitation of coronary flow reserve in patients with HCM in the absence of epicardial coronary artery disease, offering powerful evidence of microvascular dysfunction. 3 The relation of reduced MBF reserve and myocardial fibrosis using MRI has been well established in HCM.…”

Section: See Related Article Pp 1125-1134mentioning

confidence: 99%

“…3 The relation of reduced MBF reserve and myocardial fibrosis using MRI has been well established in HCM. [33][34][35] Indeed, the identification of significantly reduced MBF reserve by PET has been shown to be a powerful predictor of subsequent mortality in HCM. 34 Bravo has summarized the role of PET for detection of myocardial ischemia in HCM.…”

Section: See Related Article Pp 1125-1134mentioning

confidence: 99%

Can positron emission tomography help stratify the risk of sudden cardiac death in patients with hypertrophic cardiomyopathy?

Kay

2019

Journal of Nuclear Cardiology

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“…Castagnoli et al [ 12 ] explored the role of quantitative myocardial PET for risk stratification in patients with hypertrophic cardiomyopathy (HCM). MBF <1.1 mL/min/g following dipyridamole (Dip-MBF) assessed by PET was previously identified as an important outcome predictor in HCM, although such extreme Dip-MBF impairment is only rarely observed recently.…”

Section: Cardiology—quantitative Pet Assessment Of Myocardial Perfusimentioning

confidence: 99%

Topics of nuclear medicine research in Europe

et al. 2017

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Last year in the European Journal of Nuclear Medicine and Molecular Imaging, we introduced some recent nuclear medicine research conducted in Japan. This was favorably received by European readers in the main. This year we wish to focus on the Annals of Nuclear Medicine on some of the fine nuclear medicine research work executed in Europe recently. In the current review article, we take up five topics: prostate-specific membrane antigen imaging, recent advances in radionuclide therapy, [18F]fluorodeoxyglucose positron-emission tomography (PET) for dementia, quantitative PET assessment of myocardial perfusion, and iodine-124 (124I). Just at the most recent annual meeting of the European Association of Nuclear Medicine 2016, Kyoto was selected as the host city for the 2022 Congress of the World Federation of Nuclear Medicine and Biology. We hope that our continuous efforts to strengthen scientific cooperation between Europe and Japan will bring many European friends and a great success to the Kyoto meeting.

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Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal

Cited by 20 publications

References 38 publications

Inline perfusion mapping provides insights into the disease mechanism in hypertrophic cardiomyopathy

Inline perfusion mapping provides insights into the disease mechanism in hypertrophic cardiomyopathy

Can positron emission tomography help stratify the risk of sudden cardiac death in patients with hypertrophic cardiomyopathy?

Topics of nuclear medicine research in Europe

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