Role of quantum dots in pharmaceutical and biomedical analysis, and its application in drug delivery

Badıllı, Ulya; Mollarasouli, Fariba; Bakırhan, Nurgul K.; Özkan, Yalçın; Özkan, Síbel A.

doi:10.1016/j.trac.2020.116013

Cited by 100 publications

(28 citation statements)

References 64 publications

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“…Because of the shortcomings of fluorescent dyes, such as poor photobleaching resistance and vulnerability of the fluorescence performance to external factors, some fluorescent nanomaterials with better performance have been applied to the construction of fluorescent aptasensors for AGs. Quantum dots (QDs) have attracted much attention because of their unique optical and electronic properties, including high luminescence, strong light stability, good resistance to light bleaching, wide absorption bands, and adjustable sizes [96,97]. Wu [69] designed a novel fluorescent switch sensor using QDs labeled with ssDNA binding protein (SSB) and exonuclease I for assisted target recovery, and applied it to streptomycin detection (Figure 3A).…”

Section: Fluorescent Aptamer Sensorsmentioning

confidence: 99%

Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

Luan

Wang

et al. 2020

Antibiotics

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Antibiotic abuse is becoming increasingly serious and the potential for harm to human health and the environment has aroused widespread social concern. Aminoglycoside antibiotics (AGs) are broad-spectrum antibiotics that have been widely used in clinical and animal medicine. Consequently, their residues are commonly found in animal-derived food items and the environment. A simple, rapid, and sensitive detection method for on-site screening and detection of AGs is urgently required. In recent years, with the development of molecular detection technology, nucleic acid aptamers have been successfully used as recognition molecules for the identification and detection of AGs in food and the environment. These aptamers have high affinities, selectivities, and specificities, are inexpensive, and can be produced with small batch-to-batch differences. This paper reviews the applications of aptamers for AG detection in colorimetric, fluorescent, chemiluminescent, surface plasmon resonance, and electrochemical sensors for the analysis in food and environmental samples. This study provides useful references for future research.

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Section: Fluorescent Aptamer Sensorsmentioning

confidence: 99%

Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

Luan

Wang

et al. 2020

Antibiotics

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“…QDs as effectual fluorescent labels can be utilized for designing innovative drug delivery systems to observe the metabolism of drugs in the body due to their exclusive physicochemical properties and low toxicity. 78 The modification of QD surfaces in targeted drug and vaccine delivery performs a significant function in the obstruction, treatment and management of viral infections. 79 As an example, QD‐based highly active antiretroviral therapy, amprenavir drug formulation, could across the blood–brain barrier and expressively inhibit HIV‐1 replication in infected peripheral blood mononuclear cells.…”

Section: Qds For Drug and Vaccine Delivery Formulations Agai...mentioning

confidence: 99%

“…Among various nanocarriers deployed for biomedical and pharmaceutical applications, QDs as semiconductor nanocrystals are attractive candidates according to their unique properties and suitable biocompatibility/low toxicity. QDs as effectual fluorescent labels can be utilized for designing innovative drug delivery systems to observe the metabolism of drugs in the body due to their exclusive physicochemical properties and low toxicity 78 . The modification of QD surfaces in targeted drug and vaccine delivery performs a significant function in the obstruction, treatment and management of viral infections 79 .…”

Section: Qds For Drug and Vaccine Delivery Formulations Against Covid‐19mentioning

confidence: 99%

Quantum dots against SARS‐CoV‐2: diagnostic and therapeutic potentials

Rabiee

Ahmadi

Soufi

et al. 2022

J of Chemical Tech & Biotech

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The application of quantum dots (QDs) for detecting and treating various types of coronaviruses is very promising, as their low toxicity and high surface performance make them superior among other nanomaterials; in conjugation with fluorescent probes they are promising semiconductor nanomaterials for the detection of various cellular processes and viral infections. In view of the successful results for inhibiting SARS‐CoV‐2, functional QDs could serve eminent role in the growth of safe nanotherapy for the cure of viral infections in the near future; their large surface areas help bind numerous molecules post‐synthetically. Functionalized QDs with high functionality, targeted selectivity, stability and less cytotoxicity can be employed for highly sensitive co‐delivery and imaging/diagnosis. Besides, due to the importance of safety and toxicity issues, QDs prepared from plant sources (e.g. curcumin) are much more attractive, as they provide good biocompatibility and low toxicity. In this review, the recent developments pertaining to the diagnostic and inhibitory potentials of QDs against SARS‐CoV‐2 are deliberated including important challenges and future outlooks. © 2022 Society of Chemical Industry (SCI).

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“…Further, DMSO and ethanol are commonly used solvents that provide good solubility. However, the applications of GQDs in bioimaging and selective drug delivery systems have been greatly affected by the increased solubility in aqueous solvents [33]. Moreover, the potential to be water-soluble is due to the units containing hydroxyl and carboxyl attached to the GQDs edges since the hydrophilicity of GQDs is enhanced by surface functionality, and it can be controlled by synthetic methods and hence, tuning the chemical properties [34].…”

Section: Introductionmentioning

confidence: 99%

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

et al. 2021

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Graphene quantum dots (GQD) is an efficient nanomaterial composed of one or more layers of graphene with unique properties that combine both graphene and carbon dots (CDs). It can be synthesized using carbon-rich materials as precursors, such as graphite, macromolecules polysaccharides, and fullerene. This contribution emphasizes the utilization of GQD-based materials in the fields of sensing, bioimaging, energy storage, and corrosion inhibitors. Inspired by these numerous applications, various synthetic approaches have been developed to design and fabricate GQD, particularly bottom-up and top-down processes. In this context, the prime goal of this review is to emphasize possible eco-friendly and sustainable methodologies that have been successfully employed in the fabrication of GQDs. Furthermore, the fundamental and experimental aspects associated with GQDs such as possible mechanisms, the impact of size, surface alteration, and doping with other elements, together with their technological and industrial applications have been envisaged. Till now, understanding simple photo luminance (PL) operations in GQDs is very critical as well as there are various methods derived from the optical properties of manufactured GQDs can differ. Lack of determining exact size and morphology is highly required without loss of their optical features. Finally, GQDs are promising candidates in the after-mentioned application fields.

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Role of quantum dots in pharmaceutical and biomedical analysis, and its application in drug delivery

Cited by 100 publications

References 64 publications

Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

Advances in the Application of Aptamer Biosensors to the Detection of Aminoglycoside Antibiotics

Quantum dots against SARS‐CoV‐2: diagnostic and therapeutic potentials

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

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