Role of quercetin as an alternative for obesity treatment: You are what you eat!

Nabavi, Seyed Fazel; Russo, Gian Luigi; Daglia, Maria; Nabavi, Seyed Mohammad

doi:10.1016/j.foodchem.2015.02.006

Cited by 274 publications

(155 citation statements)

References 76 publications

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“…The p-coumaric acid has antioxidant, antilipidemic, antihypertrophic and cardioprotective properties [10,11]. Quercetin shows a wide range of biological and pharmacological effects, including antioxidant, anti-inflammatory, antitumor and antibacterial activities, as well as neuroprotective, hepatoprotective, cardioprotective, anti-atherosclerotic, anti-thrombotic and antihypertensive effects [12][13][14][15]. In tomato, quercetin is commonly found in the glycoside, i.e., esterified with rutinose.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted extraction of phenolic acids and flavonoids and production of antioxidant ingredients from tomato: A nutraceutical-oriented optimization study

Pinela

Prieto

Carvalho

et al. 2016

Separation and Purification Technology

120

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The production of natural extracts requires suitable processing conditions to maximize the preservation of the bioactive ingredients. Herein, a microwave-assisted extraction (MAE) process was optimized, by means of response surface methodology (RSM), to maximize the recovery of phenolic acids and flavonoids and obtain antioxidant ingredients from tomato. A 5-level full factorial Box-Behnken design was successfully implemented for MAE optimization, in which the processing time (t), temperature (T), ethanol concentration (Et) and solid/liquid ratio (S/L) were relevant independent variables. The proposed model was validated based on the high values of the adjusted coefficient of determination and on the non-significant differences between experimental and predicted values. The global optimum processing conditions (t=20 min; T=180 ºC; Et=0 %; and S/L=45 g/L) provided tomato extracts with high potential as nutraceuticals or as active ingredients in the design of functional foods. Additionally, the round tomato variety was highlighted as a source of addedvalue phenolic acids and flavonoids.

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Section: Introductionmentioning

confidence: 99%

Microwave-assisted extraction of phenolic acids and flavonoids and production of antioxidant ingredients from tomato: A nutraceutical-oriented optimization study

Pinela

Prieto

Carvalho

et al. 2016

Separation and Purification Technology

120

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show abstract

“…Various factors such as body metabolism, diet, physical activity, familial tendency, hypothalamic dysfunction, environmental and genetic factors may lead to obesity [1,2]. In 2008, nearly 500 million human were obese and 1.5 billion persons were overweight in the world [3].…”

Section: Introductionmentioning

confidence: 99%

Preventive effects of quercetin on liver damages in high-fat diet-induced obesity

Gedikli¹,

Özkanlar²,

Gür³

et al. 2017

J Histol Histopathol

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Background: Obesity is a worldwide health problem and causes many important illnesses. The current study aimed to investigate the influence of quercetin over apoptosis by inflammatory activity on high-fat dietinduced liver damage. Material and methods: Totally 18 adult female Sprague-Dawley rats were selected and randomly separated equally into three groups, followed as control, obesity and obesity-quercetin groups. Obesity and obesityquercetin groups were fed a moderately high fat diet for 120 days. After obesity occurred, quercetin dissolved in the corn oil and given obesity-quercetin group at dose of 50 mg/kg by oral gastric way for 15 days. All animals were sacrificed with an anesthesia at the end of the experiment, and venous blood samples were collected from the right ventricle and hepatic markers were evaluated by using commercially available diagnostic kits. In addition, liver sections were analysed by histopathologic and immunohistochemical procedures. Also, we evaluated the expression of Bax and Bcl-2 by immunohistochemistry. Results: Obesity induced important change (p<0.05) in the most of biochemical parameters, hepatic markers, and Bax immunoreactivity as well. But, the level of Bcl-2 was slightly increased, in contrast, the level of Bax decreased markedly (p<0.05) in the obesity-quercetin group. Conclusions: Both immunohistochemical evidence and biochemical results showed that application of quercetin decreased the obesity mediated damage to the liver.

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“…Mostly, It's available in many human foods especially fruits, leaves, grains, and vegetables (12). It characterizes by a phenyl benzo (c) pyrone derived structure as represented by its chemical structure shown in figure 1 (13).…”

Section: Quercetinmentioning

confidence: 99%

“…Finally lyophilizing each condensed samples in a freeze-dryer to obtain a crude ethanol Extract (EF), 80% ethanolic extract, and water extract. Lastly, all extracts were stored at 4 °C for subsequent analysis (12). The below equation used to determine the yield as percentage of the quantity of the initial material of (100g).…”

Section: Extraction From Corn Silkmentioning

confidence: 99%

Detection of Rutin, Kaepferol, and Quercetin based Crude from Corn Silk and Studying their Effects on the Inhibition of Pure Urease Enzyme and Urease of Klebsiella Species

Ismael¹,

Ahmed²,

Mahmoud³

2017

Int.J.Curr.Microbiol.App.Sci

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Role of quercetin as an alternative for obesity treatment: You are what you eat!

Cited by 274 publications

References 76 publications

Microwave-assisted extraction of phenolic acids and flavonoids and production of antioxidant ingredients from tomato: A nutraceutical-oriented optimization study

Microwave-assisted extraction of phenolic acids and flavonoids and production of antioxidant ingredients from tomato: A nutraceutical-oriented optimization study

Preventive effects of quercetin on liver damages in high-fat diet-induced obesity

Detection of Rutin, Kaepferol, and Quercetin based Crude from Corn Silk and Studying their Effects on the Inhibition of Pure Urease Enzyme and Urease of Klebsiella Species

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