Role of radical pairs and feedback in weak radio frequency field effects on biological systems

Abstract

Radio frequency electromagnetic fields (RF) have been shown to modify the concentrations of the radical O, HO and cancer cell growth rates at exposure levels below those that cause significant heating. Reactive oxygen species (ROS) are both signaling molecules and species that can do damage, depending on timing, location and concentrations. We briefly look at some mechanisms by which electromagnetic fields can modify the concentrations of ROS and some of the feedback and repair processes that lead to variable biological effects. Of particular interest are the role of radical pairs and their spins, which have received considerable attention recently, and the role of feedback in biological systems, to which less attention has been paid.

On the magnetosensitivity of lipid peroxidation: two- versus three-radical dynamics

“…Such effects are, for example, detailed in the review by Valko et al 74 The magnetosensitivity of such reactions could in principle have a significant impact on the long-term risk assessment of magnetic field exposure, as oxidative stress has been linked to the pathogenesis of several human diseases including, notably, cancer. 75 Clearly, many more experimental and theoretical studies will be necessary to substantiate or refute this possible link. Here, we only provide one more puzzle stone to our understanding of which processes are to be considered in the first place.…”

The Hyperfine Coupling Radical Pair Mechanism of Biological Effects on Weak Magnetic Fields

“…Some references [1]; [25]; [29]; [36]; [42]; [62]; [87]; [94]; [101]; [102] discussed the problems of the irreproducible bioeffects of weak magnetic fields. Some references [1]; [36]; [62]; [101]; [102] explained the reasons in different view points. What are the primary physical mechanisms of the problems?…”

“…Apollonio, et al [101] reported the other biological effects of RF-MFs. For a long time, there have been substantial concerns over the possible effects of RF-MFs at exposure levels that do not lead to significant increases in temperature [62]. Possible health effects of RF-MFs on the human body are still in discussion and have not finally been verified [100,101].…”

“…The mechanisms of biological effects of ELF-MFs which are cyclotron resonance theory and it's new interpretation,the ion parametric resonance model and an interference of ions bound within proteins are proposed [58][59][60][61]. The radical pair mechanism of biological effects of RF-MFs are outlined [1]; [62,63]. Because magnetic fields in the band of 300 Hz through 10 MHz between ELF-MFs and RF-MFs have not been sufficiently explored so far [64] the mechanisms of biological effects of an intermediate frequency magnetic fields(IMF-MFs) have not been reported to the author's known.…”

Electrical and Magnetodielectric Properties of Magneto-Active Fabrics for Electromagnetic Shielding and Health Monitoring

“…Recent technological advancements in various fields such as telecommunications, computer science or satellite broadcasts expose human beings to significant increases of the radiation levels of electromagnetic radiations (EMR), especially those arising from the fast-developing 5G technology [ 1 ]. Many recent studies have shown that exposure to EMR is causing health hazards for human beings, plants and animals [ 2 , 3 , 4 , 5 ] at levels well below most of the accepted international guidelines [ 6 ]. The damage goes well beyond living organisms, and includes disruption of the functionality and performance of many electronic devices, slows down their efficiency and degrades the reliability, lifetime and safety of electrical equipment [ 7 , 8 , 9 ].…”