Role of radiotherapy for mucoepidermoid carcinoma of salivary gland

Hosokawa, Yoichiro; Shirato, Hiroki; Kagei, Kenji; Hashimoto, S; Nishioka, Takeshi; Tei, Kanchu; Ono, M.; Ohmori, Keiichi; Kaneko, Masanori; Miyasaka, Kazuo; Nakamura, Motoyasu

doi:10.1016/s1368-8375(98)00053-0

Cited by 67 publications

(47 citation statements)

References 23 publications

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“…In general, postoperative radiotherapy for parotid tumors is recommended for patients with high-grade histology, recurrent disease, inadequate surgical margins, perineural invasion, extension of disease beyond the gland, and nodal disease. 12,[15][16][17][18][19] Postoperative radiotherapy was used in a large number of intermediate-grade and low-grade tumors and in view of presumed adverse prognostic factors like node and margin positivity, advanced stage, and recurrence. In addition, other factors that governed the decision favoring PORT in this subset of patients were: degree of reliability regarding the optimal surgical procedure and accuracy of histopathologic reporting, likelihood of patient's return for follow-up examination, accessibility of patient to expert oncology care, and feasibility of salvage neck dissection on a case-to-case basis.…”

Section: Resultsmentioning

confidence: 99%

Mucoepidermoid carcinoma of the parotid gland: Factors affecting outcome

et al. 2011

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Section: Resultsmentioning

confidence: 99%

Mucoepidermoid carcinoma of the parotid gland: Factors affecting outcome

et al. 2011

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“…An increase of Ki-67 has been discussed in order to differentiate between malignant and benign gland tissue [18,23] but has not been established in clinical routine to date. Although radio-resistance is discussed, radiation is recommended in patients with positive surgical margins and high-grade tumors [15,24]. Tran et al reported an improvement of local control by RT in patients with positive surgical margins from 50% to 71% [25].…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

Malignant minor salivary gland tumors: a retrospective study of 27 cases

Kruse

Grätz

Obwegeser

et al. 2010

Oral Maxillofac Surg

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Purpose Malignant tumors of the intra-oral minor salivary glands are uncommon. The aim of this study was to give information concerning the clinical features of these tumors, the distribution of location, treatment opportunities, and outcome. Methods Twenty-seven patients with malignant salivary gland tumors that were treated between January 1999 and December 2008 were evaluated retrospectively. Results Of the 27 minor salivary gland carcinomas, 48.1% were adenoid cystic carcinomas (ACC), 29.7% mucoepidermoid carcinomas (MEC), 22.2% adenocarcinomas (ADCA). The most common first symptom was a painless swelling in 60% of the cases, with the second most common symptom being ulcers (28%). Four recurrences and two metastases were found. No recurrence was observed in ADCA. All four patients experiencing a recurrence developed it in the first 3 years after treatment. Conclusion Wide excision with a clinical margin of 1 cm and in large tumors, positive surgical margins or perineural infiltration and postoperative radiotherapy (RT) can be recommended; but in order to give exact information concerning the possible benefit from postoperative RT, it needs large prospective multicenter studies. Long-term follow-up controls and in particularly longer than 5 years in ACC including yearly chest X-rays should be offered to these patients because of late metastasis and recurrences.

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“…The literature documenting MEC arising from the lingual tonsils is sparse and consists largely of case reports and case series, many of which include records dating back decades [2,[5][6][7][8][9][10][11][12][13]. The mainstay of treatment for MEC is surgical resection.…”

Section: B a Discussionmentioning

confidence: 99%

A rare case of mucoepidermoid carcinoma of the lingual tonsil with cervical lymph node metastases

Lawlor

Nelson²,

Doucet³

et al. 2015

J Cancer Ther Res

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Background: Although squamous cell carcinoma accounts for >90% of all oropharyngeal neoplasms, other rare neoplasms have been reported. Here, we present a case of mucoepidermoid carcinoma of the lingual tonsil. Methods and results:A 66-year-old male presented with a right neck mass and right base of tongue fullness. Fine needle aspiration of the neck mass and surgical biopsy of the base of tongue lesion revealed a low-grade mucoepidermoid carcinoma, ultimately staged as a T4N2aM0 neoplasm. Our multi-disciplinary tumor board recommended a right mandibulotomy, partial glossectomy, radical tonsillectomy, lateral pharyngeal wall resection, selective neck dissection levels II-IV, and reconstruction with an anterior lateral thigh flap followed by adjuvant radiation. Conclusion: Mucoepidermoid Carcinoma is the most common malignant salivary gland neoplasm; however, mucoepidermoid carcinoma arising from minor salivary rests within the lingual tonsils is exceedingly rare, presenting a diagnostic and therapeutic dilemma.

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Role of radiotherapy for mucoepidermoid carcinoma of salivary gland

Cited by 67 publications

References 23 publications

Mucoepidermoid carcinoma of the parotid gland: Factors affecting outcome

Mucoepidermoid carcinoma of the parotid gland: Factors affecting outcome

Malignant minor salivary gland tumors: a retrospective study of 27 cases

A rare case of mucoepidermoid carcinoma of the lingual tonsil with cervical lymph node metastases

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