Role of radiotherapy in the chemotherapy-containing multidisciplinary management of patients with resected pancreatic adenocarcinoma

Sole, Claudio V.; Atahualpa, Freddy; Berlin, Alejandro; Herranz, R.; González-Bayón, L.; García-Sabrido, J.L.

doi:10.1007/s00066-014-0759-1

Cited by 1 publication

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References 28 publications

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“…We recently examined the functional capacity of γδTc from patients with PDAC ( 16 ). PDAC is a highly aggressive gastrointestinal malignancy characterized by the presence of desmoplastic stromal microenvironment where conventional treatment approaches including surgery, chemotherapy, and/or radiation are often not effective ( 19 ). The observed decrease in absolute Vδ2 T cell numbers in untreated patients with advanced PDAC is attributable to age, not disease status, as similar numbers were found in age-matched healthy controls ( 16 ).…”

Section: Determination Of Cytotoxic Capacitymentioning

confidence: 99%

Monitoring Circulating Î³Î´ T Cells in Cancer Patients to Optimize Î³Î´ T Cell-Based Immunotherapy

et al. 2014

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The success of γδ T cell-based immunotherapy, where the cytotoxic activity of circulating γδ T lymphocytes is activated by nitrogen-containing bisphosphonates (n-BP), or possibly by bispecific antibodies or the combination of both, requires a profound knowledge of patients’ γδ T cells. A possible influence of radio- or chemotherapy on γδ T cells as well as their reported exhaustion after repetitive treatment with n-BP or their lack of response to various cancers can be easily determined by the monitoring assays described in this perspective article. Monitoring the absolute cell numbers of circulating γδ T cell subpopulations in small volumes of whole blood from cancer patients and determining γδ T cell cytotoxicity using the Real-Time Cell Analyzer can give a more comprehensive assessment of a personalized tumor treatment. Possible future directions such as the combined usage of n-BP or phosphorylated antigens together with bispecific antibodies that selectively target γδ T cells to tumor-associated antigens, will be discussed. Such strategies induce expansion and enhance γδ T cell cytotoxicity and might possibly avoid their exhaustion and overcome the immunosuppressive tumor microenvironment.

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Section: Determination Of Cytotoxic Capacitymentioning

confidence: 99%

Monitoring Circulating Î³Î´ T Cells in Cancer Patients to Optimize Î³Î´ T Cell-Based Immunotherapy

et al. 2014

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Role of radiotherapy in the chemotherapy-containing multidisciplinary management of patients with resected pancreatic adenocarcinoma

Abstract: Although adjuvant CT is still the standard of care for resected pancreatic tumors, OS remains modest owing to the high risk of distant metastases. Locoregional treatment needs to be tested in the context of more efficient systemic therapy.

Cited by 1 publication

References 28 publications

Monitoring Circulating Î³Î´ T Cells in Cancer Patients to Optimize Î³Î´ T Cell-Based Immunotherapy

Monitoring Circulating Î³Î´ T Cells in Cancer Patients to Optimize Î³Î´ T Cell-Based Immunotherapy

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