Role of Reactive Oxygen Species (ROS) and Advanced Glycation End Products (AGE) in the Malfunctioning of Dental Implants

Guo, Mingzhou; Liu, Lei; Zhang, J; M, Liu

doi:10.7727/wimj.2014.105

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…However, the redox imbalance in the course of peri-implantitis is less severe than in periodontal diseases. Similar results of redox equilibrium changes were obtained by Guo et al [ 54 ]. but it should be emphasized that these observations were found in patients’ saliva.…”

Section: Fixations and Dental Implantssupporting

confidence: 90%

The Effect of Selected Dental Materials Used in Conservative Dentistry, Endodontics, Surgery, and Orthodontics as Well as during the Periodontal Treatment on the Redox Balance in the Oral Cavity

Zieniewska

Maciejczyk

2020

IJMS

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Oxidative stress (OS) is a redox homeostasis disorder that results in oxidation of cell components and thus disturbs cell metabolism. OS is induced by numerous internal as well as external factors. According to recent studies, dental treatment may also be one of them. The aim of our work was to assess the effect of dental treatment on the redox balance of the oral cavity. We reviewed literature available in PubMed, Medline, and Scopus databases, including the results from 2010 to 2020. Publications were searched according to the keywords: oxidative stress and dental monomers; oxidative stress and amalgam; oxidative stress and periodontitis, oxidative stress and braces, oxidative stress and titanium; oxidative stress and dental implants, oxidative stress and endodontics treatment, oxidative stress and dental treatment; and oxidative stress and dental composite. It was found that dental treatment with the use of composites, amalgams, glass-ionomers, materials for root canal filling/rinsing, orthodontic braces (made of various metal alloys), titanium implants, or whitening agents can disturb oral redox homeostasis by affecting the antioxidant barrier and increasing oxidative damage to salivary proteins, lipids, and DNA. Abnormal saliva secretion/composition was also observed in dental patients in the course of OS. It is suggested that the addition of antioxidants to dental materials or antioxidant therapy applied during dental treatment could protect the patient against harmful effects of OS in the oral cavity.

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Section: Fixations and Dental Implantssupporting

confidence: 90%

The Effect of Selected Dental Materials Used in Conservative Dentistry, Endodontics, Surgery, and Orthodontics as Well as during the Periodontal Treatment on the Redox Balance in the Oral Cavity

Zieniewska

Maciejczyk

2020

IJMS

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“…Peri-implant inflammation is characterized by a vast increase in reactive oxygen species, a.k.a ROS due to the ongoing inflammatory process (e.g. influx of polymorphonuclear granulocytes) as well as oxidative stress [22]. The model utilized in the present study was composed of a three-electrode cell with an isotonic fluid (electrolyte) as the corrosive medium.…”

Section: Methodsmentioning

confidence: 99%

“…was employed as a surrogate for ROS during peri-implant inflammation [25]. ROS are key molecules that are abundant in inflammation and characterize the aggressive environment that surrounds titanium during inflammation in peri-implantitis [22]. Previous work [26] investigated the effect of peroxide concentration in the range from 0–10% on the corrosion resistance of a Ti-alloy.…”

Section: Methodsmentioning

confidence: 99%

Determinants of corrosion resistance of Ti-6Al-4V alloy dental implants in an In Vitro model of peri-implant inflammation

et al. 2019

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BackgroundTitanium (Ti) and its alloys possess high biocompatibility and corrosion resistance due to Ti ability to form a passive oxide film, i.e. TiO2, immediately after contact with oxygen. This passive layer is considered stable during function in the oral cavity, however, emerging information associate inflammatory peri-implantitis to vast increases in Ti corrosion products around diseased implants as compared to healthy ones. Thus, it is imperative to identify which factors in the peri-implant micro-environment may reduce Ti corrosion resistance.MethodsThe aim of this work is to simulate peri-implant inflammatory conditions in vitro to determine which factors affect corrosion susceptibility of Ti-6Al-4V dental implants. The effects of hydrogen peroxide (surrogate for reactive oxygen species, ROS, found during inflammation), albumin (a protein typical of physiological fluids), deaeration (to simulate reduced pO2 conditions during inflammation), in an acidic environment (pH 3), which is typical of inflammation condition, were investigated. Corrosion resistance of Ti-6Al-4V clinically-relevant acid etched surfaces was investigated by electrochemical techniques: Open Circuit Potential; Electrochemical Impedance Spectroscopy; and Anodic Polarization.ResultsElectrochemical tests confirmed that most aggressive conditions to the Ti-6Al-4V alloy were those typical of occluded cells, i.e. oxidizing conditions (H2O2), in the presence of protein and deaeration of the physiological medium.ConclusionsOur results provide evidence that titanium’s corrosion resistance can be reduced by intense inflammatory conditions. This observation indicates that the micro-environment to which the implant is exposed during peri-implant inflammation is highly aggressive and may lead to TiO2 passive layer attack. Further investigation of the effect of these aggressive conditions on titanium dissolution is warranted.

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“…ROS promotes an increase in the products of nonenzymatic glycation, several studies report that the end products of advanced glycation (AGEs) induce proinflammatory cytokines (TNF-, IL6 and 8) and OS [32], [33]. Ramzan and Malik reported the presence of higher levels of AGEs in subjects with PI and implant failure within the first six months after implantation in which the number of AGEs was similar to those of chronic periodontitis patients [34], [35].…”

Section: Oxidative Stress (Os) and Peri-implantitismentioning

confidence: 98%

The Impact of Oxidative Stress on Dental Implants

Esquivel-Chirino

Gómez-Landeros

Carabantes-Campos

et al. 2021

EJDENT

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Periodontal disease is an inflammatory condition that alters the periodontium, resulting in destruction of the alveolar bone; without treatment the condition may lead to tooth loss. Dental implants are an alternative for substitution of naturally lost teeth as they have high success rates; however, some factors are related to its failure. Peri-implantitis (PI) is a pathological condition that affects the tissues surrounding dental implants and has been reported as the major cause of implant failure; PI and periodontal diseases are characterized by tissue inflammation and bone damage. In homeostasis conditions, reactive oxygen species (ROS) have been shown to be involved in cell maintenance, signal transduction, and repair of all tissues, but ROS overaccumulation leads to oxidative stress, which generates cell damage and tissue destruction; likewise, antioxidants protect against the destructive effects of ROS by turning free radicals into waste products. The main purpose of this review was to determine some aspects of inflammatory responses and oxidative stress and analyze their relationship with the lack of osseointegration and PI.

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Role of Reactive Oxygen Species (ROS) and Advanced Glycation End Products (AGE) in the Malfunctioning of Dental Implants

Abstract: We propose that increased AGE levels and oxidative stress, although not the only pathway, are significant mediators in the pathogenesis of peri-implantitis. Altering them may potentially be used in combination with other modalities to manage peri-implantitis.

Cited by 10 publications

References 17 publications

The Effect of Selected Dental Materials Used in Conservative Dentistry, Endodontics, Surgery, and Orthodontics as Well as during the Periodontal Treatment on the Redox Balance in the Oral Cavity

The Effect of Selected Dental Materials Used in Conservative Dentistry, Endodontics, Surgery, and Orthodontics as Well as during the Periodontal Treatment on the Redox Balance in the Oral Cavity

Determinants of corrosion resistance of Ti-6Al-4V alloy dental implants in an In Vitro model of peri-implant inflammation

The Impact of Oxidative Stress on Dental Implants

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