Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles

Cohen, Zoya; Maimon, Yair; Samuels, Noah; Berger, Raanan

doi:10.3892/ol.2017.5747

Cited by 10 publications

(17 citation statements)

References 17 publications

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“…The potential ability of autophagy to modulate cell death makes the process of autophagy an important therapeutic target of cancer (Corcelle et al, 2009). The pure compound from plant extracts have been shown to anticancer activity either ROS independent or through high ROS content/ROS induction (Cohen et al, 2017), the ROS generation triggers the production of autophagy (Scherz-Shouval and Elazar, 2007, Ling et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

The binding proximity of methyl β-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line

Alallah

Al-Hemaid

Bai

et al. 2018

Saudi Journal of Biological Sciences

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The alterations in somatic genomes that controls the mechanism of cell division as a main cause of cancer, and then the drug that specifically toxic to the cancer cells further complicates the process of the development of the widely effective potential anticancer drug. The side effects of the drug as well as the radiotherapy used for the treatment of cancer is severe; therefore, the search of the natural products from the sources of wild plants having anticancer potential is become immense importance today. The ethno-medicinal survey undertaken in Al-Fayfa and Wadi-E-Damad region of southern Saudi Arabia revealed that the Caralluma retrospiciens (Ehrenb.) N.E.Br. (family Apocynaceae) is being used for the treatment of cancer by the native inhabitants. The biological evaluation of anticancer potential of bioassay-guided fractionations of methanolic extract of whole plant of C. retrospiciens against human breast adenocarcinoma cell line (MCF-7) followed by characterization using spectroscopic methods confirmed the presence of methyl β-lilacinobioside, a novel active constituent reported for the first time from C. retrospiciens, is capable of inhibition of cell proliferation and induction of apoptosis in MCF-7 cells by regulating ROS mediated autophagy, and thus validated the folkloric claim. Based on a small-scale computational target screening, Topoisomerase II was identified as the potential binding target of methyl β-lilacinobioside.

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Section: Resultsmentioning

confidence: 99%

The binding proximity of methyl β-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line

Alallah

Al-Hemaid

Bai

et al. 2018

Saudi Journal of Biological Sciences

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“…The majority of cytotoxic agents against cancer cells are generally accepted to kill cancer cells though excessive ROS production [23,36]. These anticancer agents can also induce ROS production in nontumorous bystander cells to cause the development of adverse effects.…”

Section: Discussionmentioning

confidence: 99%

“…Induction of ROS is among the predominant cytotoxic mechanisms of anticancer agents [23,24]. Dox is an important chemotherapeutic agent in treatment against lymphoid malignancies, including MM [25].…”

Section: Dox Facilitates Rankl-mediated Osteoclastogenesis Through Romentioning

confidence: 99%

The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat

Ashtar

Tenshin

Teramachi

et al. 2020

Cancers

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Receptor activator of NF-κB ligand (RANKL), a critical mediator of osteoclastogenesis, is upregulated in multiple myeloma (MM). The xanthine oxidase inhibitor febuxostat, clinically used for prevention of tumor lysis syndrome, has been demonstrated to effectively inhibit not only the generation of uric acid but also the formation of reactive oxygen species (ROS). ROS has been demonstrated to mediate RANKL-mediated osteoclastogenesis. In the present study, we therefore explored the role of cancer-treatment-induced ROS in RANKL-mediated osteoclastogenesis and the suppressive effects of febuxostat on ROS generation and osteoclastogenesis. RANKL dose-dependently induced ROS production in RAW264.7 preosteoclastic cells; however, febuxostat inhibited the RANKL-induced ROS production and osteoclast (OC) formation. Interestingly, doxorubicin (Dox) further enhanced RANKL-induced osteoclastogenesis through upregulation of ROS production, which was mostly abolished by addition of febuxostat. Febuxostat also inhibited osteoclastogenesis enhanced in cocultures of bone marrow cells with MM cells. Importantly, febuxostat rather suppressed MM cell viability and did not compromise Dox's anti-MM activity. In addition, febuxostat was able to alleviate pathological osteoclastic activity and bone loss in ovariectomized mice. Collectively, these results suggest that excessive ROS production by aberrant RANKL overexpression and/or anticancer Cancers 2020, 12, 929 2 of 16 treatment disadvantageously impacts bone, and that febuxostat can prevent the ROS-mediated osteoclastic bone damage.

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“…The researchers, therefore, studied the anti-cancer potential effect of both ethanolic plant extracts in further experiments. HCT was cytotoxic against many types of cancer cells, for example MCF-7 [9] and MDA-MB-231 [10]. Yet, there is still no report of the PR toxic effect on both types of breast cancer cells.…”

Section: Identification Of Phytochemical Compositions In H Cordata Amentioning

confidence: 99%

The Effects of Houttuynia cordata Thunb and Piper ribesioides Wall Extracts on Breast Carcinoma Cell Proliferation, Migration, Invasion and Apoptosis

2020

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Houttuynia cordata Thunb. (HCT) and Piper ribesioides Wall. (PR) are common herbs that are widely distributed throughout East Asia and possess various biological properties including anti-cancer effects. However, in breast cancer, their mechanisms responsible for anti-carcinogenic effects have not been clarified yet. In this study, the inhibitory effects of HCT and PR ethanolic extracts on breast cancer cell proliferation, migration, invasion and apoptosis were examined. In MCF-7 and MDA-MB-231 cells, HCT and PR extracts at low concentrations can inhibit colony formation and induce G1 cell cycle arrest by downregulating cyclinD1 and CDK4 expression. Additionally, HCT and PR extracts also decreased the migration and invasion of both breast cancer cell lines through inhibition of MMP-2 and MMP-9 secretion. Moreover, the induction of apoptosis was observed in breast cancer cells treated with high concentrations of HCT and PR extracts. Not only stimulated caspases activity, but HCT and PR extracts also upregulated the expression of caspases and pro-apoptotic Bcl-2 family proteins in breast cancer cells. Altogether, these findings provide the rationale to further investigate the potential actions of HCT and PR extracts against breast cancer in vivo.

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Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles

Cited by 10 publications

References 17 publications

The binding proximity of methyl β-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line

The binding proximity of methyl β-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line

The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat

The Effects of Houttuynia cordata Thunb and Piper ribesioides Wall Extracts on Breast Carcinoma Cell Proliferation, Migration, Invasion and Apoptosis

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