Role of Red Blood Cell Distribution Width as a Prognostic Marker in Patients With Severe Sepsis and Septic Shock

Punekar, Janki; Jain, Neeraj; Yawalkar, Vaibhav; Punekar, Prashant; Jain, Anshul; Parashar, Manoj Kumar

doi:10.14260/jemds/2016/258

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…RDW showed significant association with mortality on admission and day 3. In agreement, Punekar et al [29] reported that baseline RDW and 72 h later were linked to sepsis outcome. Lorente et al [30] found higher RDW in non-survivors on first day and 72 h later.…”

Section: Discussionsupporting

confidence: 65%

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Comparative study between complete blood picture indices and presepsin as early prognostic markers in septic shock patients

Said

Fayed

El-Reweny

2020

Egyptian Journal of Anaesthesia

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Section: Discussionsupporting

confidence: 65%

“…During sepsis, various pathophysiological mechanisms affect RDW, such as oxidative stress, proinflammatory cytokines, systemic inflammatory response, and renal dysfunction [29]. RDW showed significant association with mortality on admission and day 3.…”

Section: Discussionmentioning

confidence: 95%

Comparative study between complete blood picture indices and presepsin as early prognostic markers in septic shock patients

Said

Fayed

El-Reweny

2020

Egyptian Journal of Anaesthesia

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A Study of Red Cell Distribution Width in Neonatal Sepsis

El-Lahony¹,

El-Mekkawy²,

Farag³

2017

Pediatr Emer Care

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Objectives The objective of this study was to evaluate a new nontraditional value of the red cell distribution width (RDW) in predicting the clinical outcome of neonatal sepsis. Methods In this retrospective study, data were collected from the medical files of 500 full-term neonates with a diagnosis of early onset or late onset sepsis. Baseline RDW and other traditional biomarkers, including C-reactive protein (CRP), total leucocytic count, and platelet count were analyzed in light of the clinical data. The primary outcome was 30-day mortality. Results Red cell distribution width was significantly higher in nonsurvivors compared with survivors (P < 0.0001). Red cell distribution width was significantly elevated in infants with septic shock compared with those having severe sepsis and those with sepsis (P < 0.0001). A strong positive correlation was found between RDW and CRP (r = 0.8; P <0.0001). Red cell distribution width had an area under the receiver operating characteristic curve of 0.75 for prediction of mortality, which was almost equal to that of CRP and platelet count. Furthermore, logistic regression analysis showed a positive association of RDW with mortality (odds ratio, 1.31; 95% confidence interval, 1.241–1.399). Conclusions Red cell distribution width is a useful prognostic marker in neonatal sepsis. Larger prospective studies are required to confirm the value of this routinely available marker in this category of patients.

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Evaluation of Red Blood Cell Distribution Width in Newborns with Neonatal Sepsis

Mady

Elsayed

Abdelhaie

et al. 2020

Benha Journal of Applied Sciences

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Sepsis is a common and serious neonatal problem with high morbidity and mortality particularly in resource limited communities. Broad examination endeavors have yielded numerous biomarkers which are conceivably helpful, for conclusion of sepsis as well as for forecast of its result. to examine the analytic job of RDW in 50 of full term children with sepsis and to assess its job in clinical result of neonatal sepsis. This investigation was completed on 100 youngsters conceded in neonatal emergency unit of Benha University Hospital and Benha Teaching Hospital during the period from (December 2018 to February 2020). Moral Research Committee Approval and composed assents were acquired from guardians of the youngsters 50 neonatal sepsis cases and 50 typical controls. Consideration standards: age from 1-28 days and had discoveries of sepsis either clinical or lab. Youngsters were exposed to: History taking, clinical assessment for signs of sepsis. Complete blood tally, C-receptive protein, Blood culture and affectability and assurance of RDW % were done to all children. Mean RDW % was higher among cases than controls (16.7 ±1.6 and 12.9 ±1.4respectively) (P < 0.001), then hemoglobin (HB) was lower in cases than controls P=0.542. WBCs were higher among cases contrasted with control (P <0.001). CRP was typical in all controls, and was higher in all cases. RDW % was higher in serious sepsis than mellow (19.2 ± 1.8& 16.4 ± 0.5 separately) (P < 0. 001). RDW % can fill in as a symptomatic marker and anticipate sepsis seriousness as a noteworthy distinction was found between its incentive among youngsters with mellow sepsis and extreme sepsis.

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Role of Red Blood Cell Distribution Width as a Prognostic Marker in Patients With Severe Sepsis and Septic Shock

Cited by 4 publications

References 10 publications

Comparative study between complete blood picture indices and presepsin as early prognostic markers in septic shock patients

Comparative study between complete blood picture indices and presepsin as early prognostic markers in septic shock patients

A Study of Red Cell Distribution Width in Neonatal Sepsis

Evaluation of Red Blood Cell Distribution Width in Newborns with Neonatal Sepsis

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